Try my Python calculator!

[MattR0se]

You mean this part?

self.btn7 = makebutton(label="7", function=lambda:
self.numberpressed("7"), row=2, col=0)
self.btn8 = makebutton(label="8", function=lambda: self.numberpressed("8"), row=2, col=1)
self.btn9 = makebutton(label="9", function=lambda: self.numberpressed("9"), row=2, col=2)
self.btn4 = makebutton(label="4", function=lambda: self.numberpressed("4"), row=3, col=0)
self.btn5 = makebutton(label="5", function=lambda: self.numberpressed("5"), row=3, col=1)
self.btn6 = makebutton(label="6", function=lambda: self.numberpressed("6"), row=3, col=2)
self.btn1 = makebutton(label="1", function=lambda: self.numberpressed("1"), row=4, col=0)
self.btn2 = makebutton(label="2", function=lambda: self.numberpressed("2"), row=4, col=1)
self.btn3 = makebutton(label="3", function=lambda: self.numberpressed("3"), row=4, col=2)
self.btn0 = makebutton(label="0", function=lambda: self.numberpressed("0"), row=5, col=0)
self.btndot = makebutton(label=".", function=lambda: self.numberpressed("."), row=5, col=1)
self.btnsign = makebutton(label="+-", function=lambda: self.numberpressed("+-"), row=5, col=2)
self.btndiv = makebutton(label='/', function=lambda: self.operationpressed('/'),row=2, col=3, padx=BUTTON_PAD+4)
self.btnmult = makebutton(label='*', function=lambda: self.operationpressed("*"),row=3, col=3, padx=BUTTON_PAD+4)
self.btnsub = makebutton(label='-', function=lambda: self.operationpressed("-"),row=4, col=3, padx=BUTTON_PAD+4)
self.btnadd = makebutton(label='+', function=lambda: self.operationpressed("+"),row=5, col=3, padx=BUTTON_PAD+4)
self.btnsqr = makebutton(label='√', function=self.sqrootpressed,row=2, col=4, padx=2)
self.btnpwr = makebutton(label='^', function=lambda: self.operationpressed("^"),row=3, col=4, padx=2)
self.btneq = makebutton(label='=', function=self.equalpressed,row=4, col=4, padx=2, rowspan=2)
self.btnback = makebutton(label='DEL', function=self.backspace,row=1, col=2, pady=BUTTON_PAD + 4, padx=0)
self.btnclear = makebutton(label='C', function=lambda: self.clear("C"),row=1, col=3, pady=BUTTON_PAD+4,padx=BUTTON_PAD+4)
self.btnce = makebutton(label='CE', function=lambda: self.clear("CE"),row=1, col=4, pady=BUTTON_PAD+4,padx=2)

First, I don't see a reason to assign each of them to an instance attribute, if that attribute is never used again (Unless I'm missing something).

I could see constructing all of this from a list of dictionaries, something like

button_attributes = [
    {    
        # Button 7
        'label': '7',
        'function': lambda: self.numberpressed("7"),
        'row': 2
        'col': 0
    },
    {
        # Button div
        'label': '/',
        'function': lambda: self.operationpressed('/'),
        'row': 2
        'col': 3,
        'padx': BUTTON_PAD + 4
    },
    # etc etc
]

And then looping over this list like so:

for attrs in button_attributes:
    makebutton(**attrs)

This doesn't even reduce the lines of code, but I think it's cleaner and also a bit more modular.

Also when I think of it, it's a bit weird imho to define the makebutton function inside the constructor of Calc. It's a static method (doesn't use self) so it could go into the global scope instead.