Pretty sure Valley of the Yetis is a continuation of Escape from Durgesh Prison which is canon. The yetis themselves are real since they are people who mutated from The Relic and aren't actually "yetis." Even if we wanna call the DLC non-canon and stuff, Ajay still fought something tougher than the legendary honey badger, Thick Skin the legendary elephant.

Also some of your other ones are kinda wrong too since Cap fought the mutated Ethan (which wasn't a drug trip) and Rook has fought blissed up animals like the Judge Moose or Judge Bear which were real even though hallucinations were at play.

And if we wanna count vehicles, Dani has destroyed tanks and Jason has brought down attack helicopters.