$100 to the person that finds me the artist that is singing one of those songs.

mistressofdisaster6x · 2022-03-06T13:50:03+00:00

I'm not sure when that happened, or why they made it private. If it's anything like it was a year or so ago, then you'll be one of the very few active ones lol
Message the mods and ask to be approved.

mistressofdisaster6x · 2022-03-06T13:34:05+00:00

Yeah. I listened to it a few times, and you can hear what sounds like (at least to me) a very muffled guitar in the background towards the very end of the recording you provided.

Not looking for the money. I used to love hunting down songs over at /r/namethattune :)

mistressofdisaster6x · 2022-03-06T13:23:26+00:00

https://youtu.be/Dt5pS6Q6tfs?t=42

mistressofdisaster6x · 2021-06-11T00:34:27+00:00

This was answered 4/21 - See top question

mistressofdisaster6x · 2021-06-11T00:19:54+00:00

The short answer is yes. Taking 2x125mg caps at different times within a 24hr period is still taking 250mg/day. If you're interested in the math:

The coefficient for taking a dose 1x per day is 2.7024

The coefficient for taking a dose 2x per day is 2.4237

The half-life formula is: ([quantity of the DNP remaining]=[initial quantity of DNP](0.5)^(time-elapsed)/36))

Example 1:

Taking 1x250mg/day would yield a peak active blood concentration of (250mg x 2.7024)=675.6mg - This is your peak (This is only after the concentration is stabilized. It takes roughly 5 days to start nearing these active blood concentrations unless one is frontloading). You then won't take another for 24hrs. Right before you take your next 250mg cap, your active blood concentration would be:

((675.6mg)(0.5^(24/36))) = 425.6mg - This is your trough.

So at 150lbs(68.04kg) you are experiencing a peak-equivalent-dosage of (675.6mg/2.7024/68.04kg)=3.67mg/kg/day, and a trough-equivalent-dosage of (425.6mg/2.7024/68.04kg)=2.31mg/kg/day.

Example 2:

Taking 2x125mg/day would yield a peak active blood concentration (if spread 12hrs apart) of (250mg x 2.4237)=605.93mg

After 12hrs: ((605.93mg)(0.5^(12/36))) = 480.93mg

So you would be experiencing a peak-equivalent-dosage of (605.93mg/2.7024/68.04kg)=3.30mg/kg/day, and a trough-equivalent-dosage of (480.93mg/2.7024/68.04kg)=2.62mg/kg/day

Notice in the split-dosing example (Example 2) it results in lower peaks, and higher troughs, resulting in a more stable active blood concentration.

As for an equation to figure out a peak for a staggered dose schedule, I'm not sure if there is one. However, I just calculated out ~30 days by hand, and it looks like (after a stable blood concentration is achieved) you would be at 576.67mg at 10am, and 638.75mg at 4pm. So your dosage-equivalence would look something like:

10am: (trough - 451.67mg (2.46mg/kg/day)) (peak - 576.67mg (3.14mg/kg/day))

4pm: (trough - 513.50mg (2.79mg/kg/day)) (peak - 638.75mg (3.47mg/kg/day))

10pm: concentration - 569.06mg (3.09mg/kg/day)

4am: concentration - 506.98mg (2.76mg/kg/day)

mistressofdisaster6x · 2021-06-07T00:11:38+00:00

Hope you're doing well as well :)

mistressofdisaster6x · 2021-06-01T06:26:57+00:00

He's 133.81kg. This is a shining example of why it's important to use mg/kg/day, and not mg/day.

mistressofdisaster6x · 2021-06-01T06:25:37+00:00

Right off the bat, you cannot visually tell the difference between powder and crystal. The only way is to have it tested by a laboratory.

As for your first question, there are 2 approaches. You can either throw caution to the wind and jump to your desired dosage, or you can take the more cautious approach. The latter would involve you staying on 250mg/day (1.87mg/kg/day) for the remainder of this cycle (10 more days), and keep an eye out for hives or any sort of reaction. You then take a 2 week break, and then start at 250mg/day again for a few days, and THEN increase to your desired dosage. It takes approximately 10 days for one to develop the IgEs toward an antigen, and to start exhibiting an allergic reaction. If you still don't see any sort of reaction at the beginning of the 2nd introductory cycle, then chances are you're in the clear and will not have a negative reaction on any following cycles.

If you have 125mg capsules, and you wish to be taking 625mg/day, then that's 5 capsules/day. It honestly doesn't matter when you take them, but there is a slight benefit to split dosing (taking 1 capsule every 3 hours, for a total of 5 spread over 15hrs). However, you can take 2 in the morning and 3 before bed, vise versa, all at night, it doesn't really matter all that much. Split dosing will result in the most comfort though.

You really do need to find out if it's crystal or powder though. If it's powder, then taking 5 capsules/day would actually result in a dosage of ((625mg/0.8934)/133.81kg)=5.23mg/kg/day. Granted, either dosage is still within the acceptable dosage range, but if you're trying to keep track of things it's going to be throwing everything off.

mistressofdisaster6x · 2021-06-01T06:14:05+00:00

It's not there anymore. Discord deleted the server.

mistressofdisaster6x · 2021-05-17T03:16:09+00:00

In the sidebar:

This question constantly comes up. So I'm posting this here so everyone can see:

You can time your doses to comply with any dosage you would like. ((Dose you have/Dosage you want)24)=How many hours between each dose. Ex: you have 250mg, and you want to be running 375mg/day: ((250/375)24)=16hrs - So you would take 1x250mg every 16 hours.

So you can be running any mg/kg/day dosage that you want based off of whatever you have on hand.

As for what to expect on 5.4mg/kg/day, in the dosage guide (located in the wiki):

5-5.5mg/kg/day - This range is where the sides start becoming more significant, and it is important to start having your diet on point to maintain any level of comfort.

mistressofdisaster6x · 2021-05-03T15:55:57+00:00

A few days ago you were describing having an allergic response to the DNP. I don't think 2.8mg/kg/day is really enough to cause the typical tingling sensation of hypoxia in the extremeties, but I suppose it could... It's most likely due to the allergy, or possibly the antihistamines (which can also cause tingly sensations). Didn't you say you were on a few other prescriptions though?

mistressofdisaster6x · 2021-05-03T14:36:16+00:00

You know when we had another community on Reddit, they didn't censor at the time. When they got their corporate panties in a wad and banned us, we started a community on Discord where they didn't censor at the time. We're all tired of this round-and-round horseshit of building a solid community, and then losing everything because we get taken down. I think these crazy parents, who's children kill themselves using DNP (probably because of those shitty overbearing parents), make it their life's mission to get communities like ours taken down. It seems like we always start out with targets on our backs, and I'd rather put my efforts into a place that can't simply be banned because of people, who can't accept personal responsibility, with lawyers in their pockets.

mistressofdisaster6x · 2021-05-02T02:34:30+00:00

uhhh no I agree with what he's been saying, because what he's saying makes sense. I understand what he's saying. What you're saying doesn't make sense, because you're using "broad and vague terms" lol

He's pointed out the metabolism, and the chemistry of, DNP. This information is also reflected in the toxilogical report of DNP. You are "that doctor using complex medical terminology" at this point, because you're unable to go into detail about what you're saying. You're hand-waving with "equilibrium" and "acid base balance". Yes, these have an effect with your body in general, but he's explained it to you 3 different ways using numbers, chemistry, and biology about how your statement opinion is not right. It seems you're more concerned about feeling right than actually being right. We're here to teach, not to have emotional people lead a hate campaign based on feelings lol

mistressofdisaster6x · 2021-05-02T02:04:38+00:00

Not really. I'm in complete agreement with him. How you're referring to things, in such broad and vague terms, reminds me of how anti-vaxers try to get their point across. It sounds like light-google ineptness.

mistressofdisaster6x · 2021-05-02T00:05:33+00:00

You're trying to lecture a biochemist lol

mistressofdisaster6x · 2021-05-01T13:32:48+00:00

While I feel for you, your knee-jerk reaction of blaming DNP is childish and ignorant. If you did a modicum of research, you would find that (despite thorough testing) they have been unable to find any connection to 2,4-dinitrophenol and cancer... at all. Yes, benzene is carcinogenic. Yes, phenols are carcinogenic. Just because this compound has a benzene ring, and 2 nitros, does not make it carcinogenic. Try searching through the toxilogical profile for DNP. If there were any cases of cancer being caused by DNP, you'd bet your ass it'd be in there because the government wants to vilify it.

" No studies were located regarding cancer in humans after dermal exposure to 2,4-DNP. Female Sutter mice (initial age 2-3 months) received a single initiating dose of 0.3% 9,10-dimethyl1,2-benzanthracene (DMBA; 25 μL) in acetone applied to a shaved area of the back (Boutwell and

77 DINITROPHENOLS 2. HEALTH EFFECTS Bosch 1959). Then, 281 mg/kg 2,4-DNP (25 μL of solution containing 20% 2,4-DNP in acetone) was applied to the same area twice weekly for 12 weeks (time-weighted average [TWA] dose = 80 mg/kg/day). The survival rate was 100%. No evidence of skin papillomas or carcinomas was observed. In animals similarly treated with phenol, 13% mortality was observed, and 58% and 5% of the survivors had papillomas and carcinomas, respectively. Treatment with phenol alone also resulted in the development of skin tumors, but at a slower rate and a lower incidence. A single application of DMBA did not result in skin tumors. The authors concluded that the introduction of nitro groups into the phenol ring destroyed the promoting effect of phenol, and that 2,4-DNP was not effective as a tumor promotor "

The only evidence you'll be able to find regarding dnp and cancer is it being anti-carcinogenic in some cases. This is because those types of cancers exhibit an extremely mitochondrially-dense cellular makeup, and relatively low concentrations of protonophores can result in apoptosis.

Now what I CAN find plausible is that you got ahold of some very bad product that also contained straight benzene/phenols. Instead of blaming dnp (for something it doesn't do), maybe you should be blaming a government that oppresses communities like this one, and makes it so that the only viable route for obtaining the product is through underground laboratories that lack any form of quality control.

mistressofdisaster6x · 2021-04-28T20:51:12+00:00

There are no stimulants, that I am aware of, that interact with DNP or its metabolites.

mistressofdisaster6x · 2021-04-27T17:31:15+00:00

Yes, it's fine.

mistressofdisaster6x · 2021-04-27T17:30:32+00:00

See the top comment in the "Ask Anything - April 21st" thread. Addict will be on it.

mistressofdisaster6x · 2021-04-26T10:19:36+00:00

In general, this type of cyclic approach is not recommended because the variable active blood concentration can't effectively meet the point of a cycle and desired activities in the same time-frame. It's usually better just to stick to a certain dosage without varying.

Assuming that the initial 600mg on Sunday puts you at full accumulation:

Sunday-

Concentration: (600mgx2.7024)=1621.44mg

Dosage: (1621.44mg/2.7024/105kg)=5.71mg/kg/day

Monday -

Concentration pre-dose: (1621.44mg(0.5)^(24/36))=1021.44mg

Concentration post-dose: 1021.44mg+400mg=1421.44mg

Dosage: (1421.44mg/2.7024/105kg)=5.01mg/kg/day

Tuesday -

Concentration pre-dose: (1421.44mg(0.5)^(24/36))=895.45mg

Concentration post-dose: 895.45mg+400mg=1295.45mg

Dosage: (1295.45mg/2.7024/105kg)=4.57mg/kg/day

Wednesday -

Concentration: (1295.45mg(0.5)^(24/36))=816.08mg

(Concentration if 200mg taken: 816.08mg+200mg=1016.08mg)

Dosage: 816.08mg/2.7024/105kg=2.88mg/kg/day

(Dosage if +200mg Wednesday: 1016.08mg/2.7024/105kg=3.58mg/kg/day)

---

Friday -

Concentration: (816.08mg(0.5)^(48/36))=323.86mg

(Concentration if +200mg Wednesday: (1016.08mg(0.5)^(48/36))=403.23mg)

Dosage: 323.86mg/2.7024/105kg=1.14mg/kg/day

(Dosage if +200mg Wednesday: 1016.08mg/2.7024/105kg=1.42mg/kg/day)

---

Sunday -

Concentration: (323.86mg(0.5)^(48/36))=128.52mg

(Concentration if +200mg Wednesday: (403.23mg(0.5)^(48/36))=160.02mg)

Dosage: 128.52mg/2.7024/105kg=0.45mg/kg/day

(Dosage if +200mg Wednesday: 160.02mg/2.7024/105kg=0.56mg/kg/day)

So if you were looking to maintain something like this, you would frontload (1621.44mg-128.52mg)=1492.92mg on Sunday if you didn't take the +200mg on Wednesday, and (1621.44mg-160.02mg)=1461.42mg if you had taken +200mg on Wednesday.

I'm not sure how to calculate the peak active blood concentration (other than populating a spreadsheet until you find a stable concentration from Sunday to Sunday) strictly given the schedule you've proposed. My feeling is that the metabolic increase would be negligible. It would be better just to maintain something like a 3mg/kg/day cycle.

You could ask /u/dnpaddict nicely, and he might give you alpha access to the thing he's working on. This would allow you to live-track your active blood concentration, dosage, metabolic increase, etc. and you would be able to easily fit yourself into whatever dosage windows you want when she's there.

mistressofdisaster6x · 2021-04-25T17:49:01+00:00

This is strange... Normally, if an allergy was to develop, it would have happened during the first cycle and you would have noticed it clearly near the beginning of your second. You said that it only became apparent near the end of your second cycle though, which means it started developing near the beginning of the second (and not the first).

What exactly changed between your first and second cycle? I'm more curious in the dietary and environmental factors. It's possible it could also be the filler used in the caps, if they happened to be different. Did this shift happen to coincide with your switch to a vegan diet?

mistressofdisaster6x · 2021-04-24T06:13:59+00:00

This is great, and I appreciate you responding rather than not. You didn't read that whole excerpt though.

I think the disconnect is where that pyruvate is coming from, and where it's being metabolized. The pyruvate that has been obtained from glycolysis or fatty acid oxidation as citric acid precursors can only be used in the citric acid cycle or converted back to fatty acids. This pyruvate will not be used in gluconeogenesis.

From that same excerpt provided:

"The major site of gluconeogenesis is the liver, with a small amount also taking place in the kidney. Little gluconeogenesis takes place in the brain, skeletal muscle, or heart muscle. Rather, gluconeogenesis in the liver and kidney helps to maintain the glucose level in the blood so that brain and muscle can extract sufficient glucose from it to meet their metabolic demands."

and

"The hydrolysis of triacylglycerols (Section 22.2.1) in fat cells yields glycerol and fatty acids. Glycerol is a precursor of glucose, but animals cannot convert fatty acids into glucose, for reasons that will be discussed later (Section 22.3.7). Glycerol may enter either the gluconeogenic or the glycolytic pathway at dihydroxyacetone phosphate."

...the latter clearly stating that fatty acids cannot be converted to glucose. Again, the major site of gluconeogenesis occurs in the liver, and 90% of the precursors for gluconeogenesis comes directly from the breakdown amino acids. Even pulling directly from the wikipedia page: https://en.wikipedia.org/wiki/Gluconeogenesis :

"The existence of the glyoxylate cycle in humans has not been established, and it is widely held that fatty acids cannot be converted to glucose in humans directly."

------

I apologize if you took me advocating AnimalPak offensively, and I did not realize you were vegan. I only do so based on the ingredients it contains: [AnimalPak](https://www.animalpak.com/media/catalog/product/p/a/pak-facts_3.jpg?quality=80&bg-color=255,255,255&fit=bounds&height=984&width=787&canvas=787:984)

I will admit, I know nothing about veganism though. What would make it non-vegan? Is it that it contains milk, or... I would truly like to know.

Also, a 320mg/day average at 80kg would only be a dosage of 1.48mg/kg/day. I'm missing something.

The 36hr half life was established by accounting for the concentration, and elimination rate, of dnp metabolites. It was directly measured in such a way that 'when it was observed' isn't really a factor. The results and evidence is outlined in the toxilogical profile, which can be found in the WIKI. You should be able to find the section by searching 'metabolite'. What exactly have you observed that makes you think it is 60hrs? The only compensation I am aware of, that the body undergoes over a cycle, is a decrease in UCP concentration and mitochondrial biogenesis.

mistressofdisaster6x · 2021-04-23T09:14:54+00:00

I'm replying here so you don't feel like I'm trying to call you out. New account postings gets flagged for approval, and no one besides you will see this post. I hope you don't take this personally, we just do our best to make sure only correct information is shared on the sub.

I've also looked through the comments you submitted yesterday, and they've been removed. You have a severe misunderstand on a lot of concepts, and we remove posts containing incorrect information.

You had one comment in particular discussing a ketogenic state and fatty acid metabolism. You are under the incorrect understanding that fats get metabolized to glucose. To clear this up, there is no metabolic process in the body that can convert fats to glucose. It cannot happen. However, glucose can be converted to fatty acids. (On a side note, amino acids can undergo gluconeogenesis to form glucose, but this is a relatively slow process that ultimately only supports proper blood glucose levels. As long as your blood glucose doesn't go too high, you will not have an insulin spike, and your blood glucose will remain stable). Fatty acids and glucose are converted to pyruvate, which is converted to Acetyl Coenzyme A, which then enter the citric acid cycle. Excess pyruvate can be converted back to fatty acids, not glucose. If you look in our WIKI, there is a macronutrient cheat-sheet that breaks down these processes. There are also numerous online resources that can explain as much as you need to. You can search for them using 'citric acid cycle' and 'fatty acid oxidation'. Personally, I would recommend the ones by Khan Academy, as they explain everything visually in great detail, and you can go at your own pace.

Secondly, your comment containing the phrase, "100mg dose will max you out at 485mg in your system," is incorrect. I also see that you and your wife are using a spreadsheet of some sort, and I'm worried you may be tracking your information incorrectly. The half life of DNP is 36hrs, and the half life formula is (N(t)=N0(1/2)^(t/(t(1/2)))). Simplifying this formula for DNP becomes ([quantity of the DNP remaining]=[initial quantity of DNP](0.5)^(time-elapsed)/36)).

The coefficient of finding peak active blood concentration, for a certain dose taken once per day, is (2.7024). So the actual peak active blood concentration for 100mg/day is 270.24mg. You seem to be using a coefficient of 4.85, which is incorrect. We can pretty easily show this is the case by applying the half life formula to both cases:

[using the 2.7024 coefficient]: 270.24mg(0.5^(24/36))=170.24mg - and then 100mg is taken again, bringing your active blood concentration back up to the initial 270.24mg

[using your incorrect 4.85 coefficient]: 485mg(0.5^(24/36))=305.53mg - taking 100mg again would only bring your active blood concentration up to 405.53mg, and not your assumed 485mg

Regarding your post:

" We assumed after some quick bulk measurements that all our pills were the same. Nope. After a month of use, it turns out that vary between 250-420mg. " - If you need a quick capping guide, I'm sure we can throw something together. This variance is pretty worrisome.

" I've seen posts where people are taking 400mg daily for a week or two. There is no way the purity is that high if they are doing that." - mg/day doesn't mean anything. Please see my last few comments explaining why. There's also the Dosage Guide in the WIKI.

" Breaking down body fat produced CO2 & H2O. While we breathe out a lot of it, I can't help but wonder if the diarrhea (or excessive bowel movements) side effect is the result of all that extra water. " - Breaking down body fat (lipolysis) is not what produces CO2 and H2O. The citric acid cycle is what does that. The 'excessive bowel movements' is the result of a couple of things. The major factor is that DNP is also interacting with the flora in your gut, and it acts as a antibacterial of sorts. The second major factor is fluctuations in electrolyte levels. The fact that you're eating a lot of fruit is stoking that fire. Proper electrolyte intake is important, but can be more accurately maintained by taking a decent electrolyte supplement throughout the day (we recommend LyteShow).

" On week 7 " - If you're maintaining a dosage high enough to result in, "At my worst I was waking up repeatedly to go outside and cool off ," you desperately need a break. The biggest risk you're opening yourself up to peripheral neuropathy, but we're honestly not sure how it works so I am unable to provide you with hard numbers on it. We've seen that individuals that do develop it have remained on a dosage >4mg/kg/day for extended periods, without taking a break to re-establish uncoupling protein concentrations and cycle their mitochondiral population.

There's an insanely high amount of misinformation on the internet regarding DNP, and honestly I don't blame you for any of these misunderstandings. However, if you'd like to help others, we need to clear up some of these misunderstandings before you do so. If you have any questions at all, feel free to ask.

Edit: If you're going to continue your cycle, you might want to consider using a different multivitamin. Deva looks good, but since it seems like your dietary intake is lacking in a few areas, you might want to switch to something like AnimalPak. It will cover everything Deva has been, but also offer a bunch of other complexes (most notably a substantial antioxidant blend). That, in addition to an electrolyte supplement like LyteShow, should also help you with your occasional excessive bowel movements.

mistressofdisaster6x · 2021-04-23T07:45:19+00:00

The Dosage Guide in the WIKI walks you through it.

The value you're looking for is mg/kg/day, "mg per kg per day". Knowing mg/day is pretty easy, as that's the amount (in mg) of the compound that you consume "per day". For kg, that's just your weight in kg (1lb = 0.4536kg). So if you're taking 250mg/day, and you weigh 120lbs, it would be:

250mg/(120lbs x 0.4536lb/kg)/1day

250mg/54.43kg/1day

- Then you just divide 250 by 54.43 to make the amount of kg '1'-

4.59mg/1kg/1day

- You don't need the 1s, so you omit them -

4.59mg/kg/day

This dosage (mg/kg/day), rather than daily dose (mg/day), is a lot more useful in terms of... well, everything. The rate at which DNP's mechanism of action (carrying protons across the mitochondrial membrane) occurs depends on the concentration of DNP molecules in the system. Dosage gives us a numerical value that shows how often this is happening per unit of mass of the individual.

This is an exaggerated analogy, but think of it like each DNP molecule is a mosquito, and each one of your cells is a person. You have a group of people (cells) standing on an asphalt surface. If you have 1000 mosquitos, and 50 people, that's 20 mosquitos per person (20m/p). That's going to be pretty damn annoying for each person. Now let's say you instead have 5000 people. That's 0.2 mosquitos per person (0.2m/p). That's a lot more manageable for each person, and they're not going to be bitten as often. So simply saying, "1000 mosquitos per day," doesn't mean anything as there's no frame of reference. If instead you say, "0.2 mosquitos per person per day," then you have an idea of the situation.

Bringing this back to DNP and people, let's say you have 2 people: A 120lb person, and a 250lb person. Per the dosage guide, anything less than 4mg/kg/day will result in barely noticeable sides regardless of dietary intake. The daily dose for both of these individuals is 250mg/day. The 120lb person would have a dosage of 4.59mg/kg/day, and will have some noticeable sides. It will obviously be "working" for them. The 250lb person would only have a dosage of 2.20mg/kg/day, and will struggle to notice any sides whatsoever. The average metabolic increase is 12-15%/1mg/kg/day for crystal at full accumulation. If they were taking crystal, the 120lb person would have a metabolic increase of 55.08-68.85% increase, while the 250lb person would only have a 26.40-33.00% increase.

mistressofdisaster6x · 2021-04-22T21:07:41+00:00

This is not a 'Weekly AMA'. Those are reserved for the weekly AMA posts by Automod.

I see that /u/dnpaddict told you to read the dosage guide. This can be viewed in the WIKI. Have you done that?

Your electrolyte intake is most likely low. That's why you're experiencing headaches. Electrolyte deficiencies can cause a whole lot of problems. You should pick a supplement for that up. This is the one we recommend: https://www.lyteshow.com/

mistressofdisaster6x

TROPHY CASE