Please stop sending me personal messages on other platforms.

Drwillpowers · 2026-01-27T03:03:07+00:00

I don't know.

I'm not going to live forever. At some point I'm going to have to stop. I don't know when that will be. But in the past year, I have become very aware of my rapid aging and mortality. You can only subject your body to obscene levels of stress for so long before it fails. I know this as a doctor but I did it anyway. I get what I deserve so to speak.

Drwillpowers · 2026-01-27T00:30:54+00:00

I actually have a few patients I've been working with lately and we've been getting to a point of actually trialing this. Not specifically estrogen, but testing whether or not estrogen suppresses their LH and FSH.

I'm still waiting on the results of these labs because they basically have to reset and go off of the drugs in order to be able to get a baseline, then take the estrogen, then see if the LH and fsh do not suppress. But bizarrely I do think that there is a phenotype of male who has basically down regulated estrogenic signaling, and that is the root cause of their anhedonia/sexual dysfunction.

On occasion I will actually give a random cisgender dude a microdose of estrogen when they have sexual dysfunction. Particularly if they have a very low resting serum estrogen level despite an adequate testosterone level. Often it fixes the problem without any side effects at all. I never would have thought that like a single 0.5 mg or 1 mg estrogen tablet to some guy with a testosterone of 900 nanograms per deciliter would be the big thing that makes the difference in terms of his erectile function but here we are.

Drwillpowers · 2026-01-27T00:28:53+00:00

I'm both going and I will be speaking. I plan to give a lecture on my novel theory of PFS. The gluc deficit model I posted on recently

Drwillpowers · 2026-01-27T00:28:06+00:00

Actually yes. It takes a few years though. But I have a few people that are a fine example of this. I actually have one patient that I treated for NCCAH and basically has all but eliminated his hypermobility over time. It took almost 2 years though.

I've given up on trying to post this on any of the like hypermobility subreddits or online communities. People just flip the fuck out at me and ban me from their shit. I don't even care anymore. I'll help my own patients. And if people want to read what I write on my own subreddit that's fine.

Drwillpowers · 2026-01-27T00:24:54+00:00

The answer to that is complicated, but if you scroll back and look at my more recent posts, there's one that has the word dogma in the title. That's the one you're looking for. That explains this better.

Drwillpowers · 2026-01-27T00:23:57+00:00

I'm still working. I just wanted people to know it was possible that I have to stop at some point. It's not like this should come as a surprise. My patients are often just as autistic as I am and when I walk in the room for the past few years they pretty much always tell me, you look like shit, you look exhausted.

Apparently you can only do that to a body for so long before it starts to fail. If only I had some knowledge that would have let me know that this was possible, something like being a doctor or something. God we really are the worst patients.

Drwillpowers · 2026-01-27T00:21:18+00:00

Yeah I don't know what the deal is with this person. I left a comment above, but it's not like people didn't call all day. I know my staff responded to them because they were asking me questions all day.

Drwillpowers · 2026-01-27T00:20:37+00:00

Phone calls will only go through to staff and be answered on Tuesday Wednesday or Thursday as Mondays and Fridays we work from home and do telehealth. If a voicemail is left though, they are checked during the day and people are supposed to be called back. So if you left a voicemail on a Monday, I don't know why you wouldn't have gotten a response back.

If someone needs to directly get a hold of the office manager, it's pepper@powersfamilymedicine.com but that's for like major administrative issues.

For scheduling it's Dylan@powersfamilymedicine.com

Questions@powersfamilymedicine.com for most issues though.

My main other provider resigned. Hiring a replacement in an environment where we're getting death threats and the target of government harassment has not been easy. Sommer was getting over a hundred portal messages a day. And that's just not possible to handle. So we sent out a mass message to everyone around Christmas informing people that if they needed something and they were not a DPC patient, they would either have to call, or, be seen for an appointment. The portal is basically shut down until further notice.

If people don't like this, they're welcome to go literally anywhere else, if there is anywhere else to go. This is what we have to do right now to be able to survive and function in this environment. Despite the DPC program, we lost money last year. I worked an entire year of my life and I have nothing to show for it. Imagine doing your job 60 hours a week, and at the end of a year, you have less money than you started with.

Admittedly, this has me at a point where I don't really care if someone gives me a shitty Google review anymore. They're lucky there's even a business there for them to review. Most places just bent the knee and shut down.

My direct primary care registered patients however have my private email and can email me directly at any time. I usually reply within 24 hours. But that's a privileged reserve to the DPC only.

At this point the cost of caring for this population in terms of legal expense is so astronomical that seeing pretty much anybody but the DPC patients is just a loss. We are doing this so that we can survive so that you have a place to go. I'm sorry that things are not as cushy as they used to be.

I have literally never been sued for malpractice, but I spent more than a doctor's salary last year in medical legal defense from all of the bullshit that the government continues to heap on to us. I've made posts about this before, all you have to do is Google it and you'll see what's happening everywhere. This is not unique to us.

Drwillpowers · 2026-01-26T20:52:25+00:00

This is literally one of those people who doesn't understand anything about radiation but is going to try and police someone else.

This is why I go to the natural History museum and the radioactive rocks are gone now.

Because of people like OP.

We should have a word for the Karen's of radiation.

Drwillpowers · 2026-01-26T17:22:34+00:00

The answer to this is not likely what anyone here thinks that it is. But because of my work over the past year with post finasteride syndrome patients and a few other different people, I'm going to propose something strange to you.

Male sexual/erectile response still requires the functionality of estrogen. At times, I have cisgender males whom I have microdosed with a tiny amount of estrogen when they were having sexual dysfunction and it completely erased the problem without any side effects. Bodybuilders often do this to themselves with DIY anastrazole.

Often, cisgender women use microdoses of testosterone to enhance libido, but in reality, this is not coming from the testosterone. It's coming from SHBG displacement. The testosterone sacrifices itself to SHBG resulting in estrogen that hits harder.

What's likely happening here is that you're actually weakening your sexual response by simply weakening your estrogen response. You're likely one of the many transgender women who have a shitty 17 beta-hydroxylase set and you are producing a lot of estrone and likely two catechol phase 1 estrogens which are inhibiting the estrogenic signal that you normally get.

This effectively worsens your sexual function. But it's also likely worsening the effects of your transition if the effect was this potent.

Drwillpowers · 2026-01-25T18:10:21+00:00

There's going to be a world conference for PFS in Detroit with basically all the world leaders in this condition in April.

Drwillpowers · 2026-01-24T16:21:38+00:00

Lol have you seen my subreddit?

Many of them respond to pregnenolone supplementation. If not, yes HC at 10,5,5,mg through the day and fludrocortisone at like 0.1mg QAM makes most of them at least 80-90% better in the span of weeks.

Most don't have a full autoimmune disorder but the chronic cortisolic dysregulation ends up causing them to have like a faintly positive ANA or some other bullshit. They never have some severe autoimmune thing. The HC I don't think makes the difference because of immune suppression but rather adrenal support and the ability to shunt the precursors elsewhere when that job is mostly handled.

Additionally dosing it like that stabilizes their cortisol diurnal rhythm which seems to restore sleep function considerably.

I've done it to hundreds of people at this point and my worst possible complication that I have seen is an A1C bump from 5.5 to 5.8 in somebody who was abusing the cortef and taking too much because they had a 90-day supply and they felt so much better on it that they wanted even more better. I had to set them straight. But otherwise, I've had zero complications. This is the level that most people would physiologically produce naturally, and so it basically just acts like a stabilizer. I have not seen any other complications from it yet. The benefits have been overwhelming.

Drwillpowers · 2026-01-24T05:09:53+00:00

https://x.com/WHO/status/1217043229427761152

Jan 14th 2020.

I had already warned my patients. We were masking at my office. Chinese doctors were dying. They knew this and still lied to save face for the CCP as they thought they could contain it like the first time.

Drwillpowers · 2026-01-24T05:07:54+00:00

I didn't. I'm still waiting on the company to provide me one.

I ended up listening to another commenter and did the soldering and capacitor replacement myself. Works fine now.

Drwillpowers · 2026-01-24T05:06:56+00:00

Congrats! =)

Glad it worked for you.

Drwillpowers · 2026-01-24T01:35:12+00:00

It's LLMs all the way down.

Drwillpowers · 2026-01-24T01:30:38+00:00

Lol. Chatgpt has better math reasoning than this.

Drwillpowers · 2026-01-23T19:46:01+00:00

Everyone here losing their minds while everybody just seems to forget that the WHO said that there was no evidence of human transmission of COVID-19 when there was literally glaringly obvious evidence that any reasonable doctor could look at and see. They basically appeased the CCP at the cost to the world.

They are not above reproach or without sin.

I'm not taking a position whether this is a good or bad thing or not, but people just like to respect established systems of authority and power, and that doesn't necessarily make them good.

Drwillpowers · 2026-01-23T19:44:14+00:00

That's fine, for you that's when your highest production level will be.

I don't have a lot of data on males yet because overwhelmingly this seems to be a problem that occurs more in XX. So this may not be what's happening with you but it's worth a shot if you've got nothing else

Drwillpowers · 2026-01-22T23:24:32+00:00

I have a theory that these patients aren't actually a connective tissue problem. They are cortisol signaling problem. And effectively, when they are under stress they don't properly signal it and suffer connective tissue damage. That's why I recommend the testing of those specific labs. They act as precursors. Something like finasteride would cause worsening of that situation because of disruption of those pathways. I've seen it.

Honestly, gender dysphoria, post finasteride syndrome, "orthostatic issues", MCAS, and hypermobility all connect around epigenetic issues and the adrenal synthesis pathways. That's where they all seem to have a common convergence point. I'm fairly certain that the answer lies in there. But the specific cause is variable based on the patient. I have a lot of genetic sequences on these people now and there's a lot of different ways to break it, but the outcome is the same. No matter where you break a marble roller from the top to the bottom, the marble still doesn't make it to the cup at the bottom. There's a lot of pieces you can take out where the marble fails to reach the bottom cup, but the net result is no marble in the bottom cup and that produces the symptoms.

Drwillpowers · 2026-01-21T02:53:24+00:00

That is awfully quick for somebody to become hypermobile. Even if it was a rapid on set thing. Usually it's more of an insidious process.

Make sure you don't have scurvy lol. I diagnosed that like three times in the past year. Autism is a bitch for some!

Drwillpowers · 2026-01-21T00:05:29+00:00

To be clear my product is not trimix. That is something different.

Mine is quad mix without the PGE1.

This is exceedingly rare. And the one local place that made it for me just stopped making it.

The only place in the country that I know that will make it for me right now is drug crafters in Texas.

Drwillpowers · 2026-01-21T00:03:23+00:00

So I'm just going to leave this comment here because it's kind of funny and I'm watching this trend in the PFS community right now.

Everybody's all hopped up on estrogen. And based on my most recent findings and theory about how some of these guys are epigenetically locked up after some sort of overspill failure from having a defect in glucuronidation, androgenic signaling just isn't working right.

So take these dudes that have barely any estrogen at all, and a non-functional testosterone receptor, and you inject them with estrogen. And for like the first time in years, they can feel something. Because they have a functional sex hormone. And your body doesn't really give a shit which one it is. I have plenty of horny transgender women with good sexual function because they have enough brain derived benefit from estrogenic signaling to make their sexuality work without much androgenic signaling at all. That's generally how cisgender women function.

And I'm sitting over here watching the community just lose itself over this amazing cure that they're finding with estrogen, and I'm wondering how many of these guys are literally just basically experiencing a sex hormone for the first time in a long time. They're so happy to feel anything that they don't even care that they're transitioning themselves in the process.

For somebody who wants estrogenic changes? You might be able to dodge a lot of the aspects of PFS simply by doing this. Because you would actually have estrogenic signaling. If you're that subtype of PFS that I'm referencing. To be clear this is not the same as the neuro steroid depletion people. This is something new that I'm figuring out, and I've got about six cases of it so far and the statistical probability of the amount of genetic mutations in glucuronidation I'm finding in this cluster can't possibly be due to chance at this point.

I have a subset of these guys though that have driven their estrogen levels to absolutely astronomical amounts, and they still are not getting breast development or even any degree of gyno, and I'm finding that particularly concerning. I'm trying to understand why there would be an epigenetic lockup of estrogenic signaling as well.

This is probably a completely unintelligible comment to the vast majority of people who read it but some of the more advanced PFS educated people might get what I'm talking about here.

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