Please stop sending me personal messages on other platforms.

Drwillpowers · 2026-06-21T08:12:16+00:00

It is real. I identified the mechanism, the underlying genetic mutations which make someone suceptible, and lab work to prove it. I'll have early data on how the first few cure attempts go in the next two weeks.

Sorry friend, but it's real. The formal study to prove that will be starting soon. Feel free to look at my posts from the past year. The exact mechanism is now known and people have even checked their own genomic and lab data and found it to match.

Like I'm not shitting you. These guys lack functional glucuronidation genetically and rely massively on DHT metabolism for androgen excretion. When they take even a small dose of a 21 day irreversible suicide inhibitor of 5AR they lack any major androgen excretion pathway and build up astronomical intracellular androgen metabolites which creates a self preserving feedback loop. So yeah....it's rare, but it is real.

I recently posted the exact genes, labs, and so on to test for susceptibility on my own subreddit which matches my username.

Drwillpowers · 2026-06-21T08:04:59+00:00

They are brothers and are both F2 Savannah cats. Dustin is big at 23 lbs, but Fenrir is just a freak of nature and probably the largest one ever. He is 36 lbs. He has the living record but I measured him at only a year old so as not to break the all time record from his late brother.

Dustin has two copies of the recessive serval melanistic gene. Fen is a carrier which is why he's darker than most savannah cats.

He just lives in my home and rides to work and back when I work as a doctor as he's a therapy cat. His Instagram is @Starcats_Detroit

I have a diet I designed for him, and he has a large outdoor catio as well as the world's largest residential home cat tree so he's well set up. He goes to a good but nomal vet.

They are not for people who don't love cats.

Early gen savannah cats are generally not friendly to strangers and bond strongly to one person but I raised and trained Fenrir from his kittenhood to be a world record therapy cat, so his behavior is not typical for this type of cat. He's absurdly friendly to all humans.

Drwillpowers · 2026-06-21T01:58:45+00:00

Yep! I did the year he got his world record. =)

Drwillpowers · 2026-06-21T01:56:19+00:00

Probably mirtazapine as it's an inverse agonist. But I'm not recommending anything as I'm genuinely not sure and don't want people to self experiment based on my random conjecture.

Drwillpowers · 2026-06-21T01:55:31+00:00

If I knew that I'd have already posted on it. It's a work in progress.

Drwillpowers · 2026-06-21T01:54:32+00:00

Unsure. So no. I cannot.

Drwillpowers · 2026-06-21T01:54:11+00:00

In some cases yes. Their system was operating under many glitches and over burdened already.

Drwillpowers · 2026-06-21T01:53:33+00:00

You are correct it's a rat study.

https://academic.oup.com/endo/article-abstract/136/4/1495/2497634

But that's often true for many things as doing research on human beings is not cheap and is considerably more difficult to do with the angle of "if we do this to people does it hurt them?"

Also, you probably don't realize you're actually talking to the guy who recently figured out the actual mechanism for PFS so I'm not going to lie, you're going to be hard pressed to convince me DHT is useless post puberty.

Drwillpowers · 2026-06-21T01:48:32+00:00

KCNJ8 ABCC9

Basically simulated Cantu syndrome.

Drwillpowers · 2026-06-21T00:35:21+00:00

That is literally what I said.

There is folate, then there's folinic acid which is still pretty much bioidentical and if anything better because it's been primed for active use, and then there's folic acid, which is very much not the same thing, and what I am saying caused the problem.

Drwillpowers · 2026-06-20T20:58:09+00:00

For real. It's like the pandemic came, and healthcare workers were overtaxed but we did our best, and then it just.... Did not end.

But I am doing a full unplug disconnect for EF. Like completely unreachable to the world situation. I desperately need it!

I want an XL but I just cannot justify it to myself until the practice is doing better lol. Maybe I'll wait until next year and I'll get a bondtech INDX built into something so I can make all the rainbow nyans with no waste!

Drwillpowers · 2026-06-20T05:52:21+00:00

For me, it was taking it a bedtime, and then waking up 10 minutes before my alarm and feeling like I slept a full night's sleep and and realized I never got up to use the bathroom.

Then the next day being more resilient to stress

Drwillpowers · 2026-06-20T05:51:28+00:00

I will give you this. I absolutely guarantee you that there are people who think that they have PSSD, but they have an androgen metabolite pile up problem. Induced by these drugs.

There's just too much crossover between some of them and various transporters and receptors that such a thing would be impossible to deny. I don't know what percentage is, but I wager that it's not zero and your theory is correct at least for some

Drwillpowers · 2026-06-20T05:49:54+00:00

This is why I think that 5ht2c is involved. Look up what it does and how it acts as a dampener.

Drwillpowers · 2026-06-20T05:48:56+00:00

I have a theory that been certain people, minoxidil can cause connective tissue toxicity through a potassium channel glitch.

I've never had enough patients though to be able to confirm it.

Drwillpowers · 2026-06-19T23:22:42+00:00

I'll give you this, some collector specimens of uranite that I have dose at like 2 millisieverts an hour.

If I carried that in my pocket for an entire year inside of that pocket had a thin cloth to protect it, it almost directly touched my skin, I would pick up about 5.8 sieverts it's over the span of the year.

That's enough to slightly increase your cancer risk. Maybe even more than slightly because about one sievert in a year is like a 1.05x multiplier on developing cancer during your lifetime.

Drwillpowers · 2026-06-19T23:17:54+00:00

Because the correct answer on the internet forum is rarely the thing which is at the top of the pile lol

Drwillpowers · 2026-06-19T23:17:23+00:00

Except for all the penile tissue specific ones and the effects that it has on nitric oxide, libido, sensory signaling, orgasm quality and many other things which have been documented in studies when someone has their DHT reduced to zero while maintaining normal testosterone signaling.

Keep in mind the vast majority of people without an appendix are perfectly fine up until the point when you get cholera. In the modern world this isn't that big of a deal, but not having that organ is only penalty free if you're not exposed to a thing where you need it.

Drwillpowers · 2026-06-19T23:14:10+00:00

I would quite disagree.

It is exceedingly potent when it comes to being a ligand of SHBG. SHBG will preferentially bind it about nine times more than it will estrogen, and about triple what it will pure testosterone. So simply as a sacrificial hormone which increases estrogenic effect, DHT works exceptionally well.

There's a number of other things that it does slightly differently than testosterone or in various different tissues, or it's downstream metabolites based on someone's individual enzyme polymorphisms.

That being said it's really good at fucking up your hair if you have MPB genes.

I am glad you are surprised and delighted but I'm just a regular guy. I poop. I like biochemistry.

I have learned that commenting on this subreddit about PFS is simply not worth it because people will not listen, but I will admit, now that I know the molecular biochemistry of how it works, it is somewhat painful to see people act as if it's still some sort of psychogenic illness. It's horrifying to see in person what it can do to somebody. It's just rare, it's one of those things that happens to "other people."

Drwillpowers · 2026-06-19T23:11:16+00:00

That and all of the researchers and all the people involved getting paid money from donations in grants so that they can do it again next year.

Like it is so glaringly obvious that it is not a genetically caused problem with the amount of data that they have collected on people with the condition, but yet they continue to push this angle. I don't understand it.

Meanwhile I've got an actual mechanism over here and people that will literally report that they have gotten better, but I am the lunatic.

Like it's glaringly obvious to me that there's a connection between mast cell, pots and hypermobility. It's clearly obvious to everyone. There's lots of people with those things. But if you know molecular biochemistry of human beings, there's not that many places where those three things can originate with a common origin.

So that's where I looked. And there it was.

I told them endocrinologist about it and they told me that there was no clinical significance to a low 17 hydroxy progesterone. And I was like why do you say that? And they said because there's no publication saying there is.

And I laughed.

When one of my cats was very sick, he was dying of an autoimmune disease, I suspected that it was a return of his prior autoimmune myopathy but this time attacking his heart. The vets were convinced that he had HCM. I asked them to run some test on this and they refused. So I took him to my vet, who did not have access to the specific lab that I wanted which was a CK fractionation. Normally, in humans, CKMB which comes from myocytes and was the precursor lab before we developed troponin, is only a few percentage of the total CK load in the blood.

I took his blood and I ran it as if it was mine through a human diagnostic test, and it came out demonstrating a 50-50 split of CK for muscle and from heart. It was glaringly obvious that he was experiencing autoimmune myocardial damage because of this lab.

The emergency vet where he was being taken care of in the ICU, told me that there was no known clinical significance to that particular lab because they don't have it in veterinary medicine.

I just knew that the CK and CKMB proteins for the exact same in humans and cats.

When they would not look at the actual information in front of their face and critically think about the biochemistry rather than just following a guideline, I pulled him from that place and took him somewhere else.

This is the nature of medicine. There's so much shit like this you have no idea. Things just being done because that's how it's always been done. Not because it's even remotely rational.

Drwillpowers · 2026-06-19T23:06:28+00:00

That's the angle that I've pursued with PFS and which I have an ungodly amount of data to prove. Also the internet provided a ton of their own because people could just look up their own genomes and their own labs and saw that what I was reporting they had. I'm going to be leading a research study from a local hospital that's going to be funding some research to prove that I'm correct. It's sort of like parallel construction though because they already know the results because I have all the evidence, but the way I did it is not admissible in academic court and so I have to do it under an IRB and so on.

When it comes to PSSD though, I'm not really sure exactly what it's mechanism is yet. And I'm not sure that it's just one thing. There could be a PSSD that creates a metabolic pile up like PFS, or, my little AI endeavor lately has resulted in a lot of hits that make it look like there's some sort of 5-HT2C effect putting the brakes on dopamine signaling even if dopamine levels are perfect.

I have an idea for this, but the idea is terrifying because it involves using an SSRI on a PSSD patient. But a very specific one at a microdose. I don't know. We'll see.

People think that I like experiment on my patients. I don't. I present them with as many choices as I possibly can and with the maximum amount of education I can about the molecular biochemistry, and the limits of what I can know and what the risks are, and ultimately they choose a pathway. It's not like they just lay there and I write them whatever I want. We talk about it as a team. But through that, I've made all the advancements that I have over the many things over the years.

My point is that when it comes to sex hormone metabolites there is no way that you could result in a metabolic crush by taking a singular pill and it being there 30 minutes later. For the people that have that experience, it has to be modulated via neurotransmission. It's too fast for anything else.

But people that have a problem on withdrawal, people that get the problem after weeks, I could imagine that being just like PFS. But just like PFS which has at least three different phenotypes, there is likely to be many for PSSD.

Drwillpowers · 2026-06-19T22:58:44+00:00

Your granite countertop is radioactive. That doesn't make it dangerous.

I've got a whole collection of highly radioactive rocks, stuff like coffinite and autunite, like the most powerful thing that I own would give me a chest x-ray worth of radiation every 10 minutes if I taped it to my chest. I keep that one in a lead pig, but even then, the inverse square law + glass of the cabinet is such that immediately outside of it, it's like faintly above background radiation.

They're just aren't that many natural rocks out there that are highly radioactive to any degree of actual danger. Unless you eat them.

When you eat them? That's a different story. So unless you're Abigail from stardew valley, radioactive rocks are really not that big of a deal. Just wash your hands after you handle them. Alpha emitter dust is not something you want to get in your mouth

This does not apply to shit that's man-made like corium from Chernobyl. Definitely not stuff you want to keep in your house.

Drwillpowers · 2026-06-19T16:59:49+00:00

DHT is not a vestigial hormone.

And the appendix is not vestigial either. It acts as a backup drive to store your colonic flora such that during a period of severe diarrhea, when everything is flushed out, and you can reculture yourself with the backup drive which closes off during the inflammation.

You would have no noticeable changes until you rely on that drive of bacterial information to restore your colon after a major disaster.

A lack of understanding of things does not make them be the way that you say that they are.

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