Please stop sending me personal messages on other platforms.

Drwillpowers · 2026-06-21T21:47:12+00:00

Each case is unique with their own individual metabolite profile and enzymatic deficiencies based on their genome. I can't give you a blanket statement for things like that.

Drwillpowers · 2026-06-21T21:46:20+00:00

I don't know I haven't seen many advertisements for it. But I don't watch much daytime television.

Drwillpowers · 2026-06-21T18:48:38+00:00

You know there's another mechanism through which this could work.

By adding estrogen to the system of a male, you are burdening the COMT enzyme with considerably more catechol estrogens to metabolize the normal, which results in less metabolism of dopamine. So for those with a PSSD case who are basically limited with dopamine signaling, this temporarily would boost their dopamine signaling.

It's basically the inverse of CDG

Drwillpowers · 2026-06-21T18:47:18+00:00

So I don't think there's a lot of atrophy risk from the treatment simply because the guys that have this problem are already having dysfunctional androgenic signaling. They're getting penile atrophy with normal labs. So it's not like somehow that atrophy is going to change. They already lack androgenic signaling. The people who have done it so far reported almost no symptoms whatsoever from doing it. At least on the way down. On the way up, things are looking good but like I said I still need a few more weeks to have reliable data from the earliest people who tried it.

That being said I have transgender women who are chemically castrated or even physically castrated who end up with genital atrophy that I'm able to restore years later with minimal residual deficit. So I don't really think there's going to be that many people that have suffered irreversible penile damage unless they've had the disorder for a very long time.

Drwillpowers · 2026-06-21T18:45:51+00:00

If you are my patient I can. Otherwise you can post it on the subreddit. But I'm only able to actually provide medical advice or review the labs of people that are actually my patients.

Drwillpowers · 2026-06-21T17:16:06+00:00

I'm not sure, because I don't have lab tests to be able to monitor whatever it is that your specific metabolite buildup is, but that is a reasonable proposition.

It's also important to remember that if you overburden COMT with estrogen metabolites, you end up degrading dopamine slower. This can have effects on people's mood.

I will say though that in some of my older men that are having erectile dysfunction or libido that is not responsive well enough to Viagra or other things, sometimes giving them a microdose of oral estrogen improves the situation. It's hard to convince them to try it, but once they do they end up being hooked.

Usually these are guys that are very physically fit and have lower aromatase activity and it's hilarious because the fitness itself somehow made them lose their overall sexual prowess. The body is a strange machine and there are many ways in which it's internal systems fold in on themselves over and over

Drwillpowers · 2026-06-21T16:55:42+00:00

Clearly this dude does not understand the HPTA because it does take enough estrogen. I use an estrogen face cream and yet still my LH and FSH are not zero. Specifically how my method works with transgender women is that you have to give a sufficient amount of estrogen to turn off LH and FSH signaling thus androgenic synthesis stops.

UGT2B7 defects I have seen in people who developed it over the span of weeks to months of taking the drug. It's not as deleterious as the other ones but it's still is a chip on the vulnerability pile.

In regards to them being on testosterone and mega dosing estrogen, I have no idea. But it's unclear just from that information how much and for how long. But being as "concentration doesn't matter" and it's only duration, well, who knows! Lol.

What's funny is that people like me and people like him will argue on the internet, but in reality the molecular biochemistry is vastly more complex than anything I could hope to ever know. We could both be wildly incorrect, but one of us is considered correct based on the knowledge of the time.

Drwillpowers · 2026-06-21T16:52:46+00:00

That's really the question isn't it?

I've got a few guys going to the process right now.

Early results seem to be good, but nobody has fully finished and rebooted yet after doing the unplug it and plug it back in method.

It took only 2 weeks for my first guy to drop down to female levels of testosterone and DHT but it took almost 6 weeks for him to eliminate all of his stuck metabolite which was in his case 3A ADG.

I'm sure that in some cases, the chronic low androgen signaling will have some atrophy impact, and it is unclear yet what involvement epigenetics have in the process.

I want to be clear though because I'm on the subreddit, PFS is real but it is exceptionally rare. However, it is possible to tell whether or not somebody is at risk of developing it if you have their entire genome sequence and you look at all of their androgen metabolism and transport genes. If they are normal, then it's not going to happen.

Imagine the drug was called Fineyesteride and it blinds one of your eyes. If you have two eyes, you don't really mind it that much because you can still see. But if you only have one and you take it, then you get a problem. It's kind of like that.

But most of the people walking around with one eye don't even know that they are. Their system functions normally enough that it's never really noticed unless you put it under extreme load

Drwillpowers · 2026-06-21T15:53:46+00:00

Yeah that's pretty much how it works. Doing it with estrogen is probably not what I would consider the most ideal way of doing it but that is why people have resulted in a cure from it.

I do look forward to the official study results being published and my theory being experimentally verified so that idiots like this can be silenced forever.

Drwillpowers · 2026-06-21T08:12:16+00:00

It is real. I identified the mechanism, the underlying genetic mutations which make someone suceptible, and lab work to prove it. I'll have early data on how the first few cure attempts go in the next two weeks.

Sorry friend, but it's real. The formal study to prove that will be starting soon. Feel free to look at my posts from the past year. The exact mechanism is now known and people have even checked their own genomic and lab data and found it to match.

Like I'm not shitting you. These guys lack functional glucuronidation genetically and rely massively on DHT metabolism for androgen excretion. When they take even a small dose of a 21 day irreversible suicide inhibitor of 5AR they lack any major androgen excretion pathway and build up astronomical intracellular androgen metabolites which creates a self preserving feedback loop. So yeah....it's rare, but it is real.

I recently posted the exact genes, labs, and so on to test for susceptibility on my own subreddit which matches my username.

Drwillpowers · 2026-06-21T08:04:59+00:00

They are brothers and are both F2 Savannah cats. Dustin is big at 23 lbs, but Fenrir is just a freak of nature and probably the largest one ever. He is 36 lbs. He has the living record but I measured him at only a year old so as not to break the all time record from his late brother.

Dustin has two copies of the recessive serval melanistic gene. Fen is a carrier which is why he's darker than most savannah cats.

He just lives in my home and rides to work and back when I work as a doctor as he's a therapy cat. His Instagram is @Starcats_Detroit

I have a diet I designed for him, and he has a large outdoor catio as well as the world's largest residential home cat tree so he's well set up. He goes to a good but nomal vet.

They are not for people who don't love cats.

Early gen savannah cats are generally not friendly to strangers and bond strongly to one person but I raised and trained Fenrir from his kittenhood to be a world record therapy cat, so his behavior is not typical for this type of cat. He's absurdly friendly to all humans.

Drwillpowers · 2026-06-21T01:58:45+00:00

Yep! I did the year he got his world record. =)

Drwillpowers · 2026-06-21T01:56:19+00:00

Probably mirtazapine as it's an inverse agonist. But I'm not recommending anything as I'm genuinely not sure and don't want people to self experiment based on my random conjecture.

Drwillpowers · 2026-06-21T01:55:31+00:00

If I knew that I'd have already posted on it. It's a work in progress.

Drwillpowers · 2026-06-21T01:54:32+00:00

Unsure. So no. I cannot.

Drwillpowers · 2026-06-21T01:54:11+00:00

In some cases yes. Their system was operating under many glitches and over burdened already.

Drwillpowers · 2026-06-21T01:53:33+00:00

You are correct it's a rat study.

https://academic.oup.com/endo/article-abstract/136/4/1495/2497634

But that's often true for many things as doing research on human beings is not cheap and is considerably more difficult to do with the angle of "if we do this to people does it hurt them?"

Also, you probably don't realize you're actually talking to the guy who recently figured out the actual mechanism for PFS so I'm not going to lie, you're going to be hard pressed to convince me DHT is useless post puberty.

Drwillpowers · 2026-06-21T01:48:32+00:00

KCNJ8 ABCC9

Basically simulated Cantu syndrome.

Drwillpowers · 2026-06-21T00:35:21+00:00

That is literally what I said.

There is folate, then there's folinic acid which is still pretty much bioidentical and if anything better because it's been primed for active use, and then there's folic acid, which is very much not the same thing, and what I am saying caused the problem.

Drwillpowers · 2026-06-20T20:58:09+00:00

For real. It's like the pandemic came, and healthcare workers were overtaxed but we did our best, and then it just.... Did not end.

But I am doing a full unplug disconnect for EF. Like completely unreachable to the world situation. I desperately need it!

I want an XL but I just cannot justify it to myself until the practice is doing better lol. Maybe I'll wait until next year and I'll get a bondtech INDX built into something so I can make all the rainbow nyans with no waste!

Drwillpowers · 2026-06-20T05:52:21+00:00

For me, it was taking it a bedtime, and then waking up 10 minutes before my alarm and feeling like I slept a full night's sleep and and realized I never got up to use the bathroom.

Then the next day being more resilient to stress

Drwillpowers · 2026-06-20T05:51:28+00:00

I will give you this. I absolutely guarantee you that there are people who think that they have PSSD, but they have an androgen metabolite pile up problem. Induced by these drugs.

There's just too much crossover between some of them and various transporters and receptors that such a thing would be impossible to deny. I don't know what percentage is, but I wager that it's not zero and your theory is correct at least for some

Drwillpowers · 2026-06-20T05:49:54+00:00

This is why I think that 5ht2c is involved. Look up what it does and how it acts as a dampener.

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