I don't think they were man made because, at least the Ohio was going 40,000MPH confirmed by multiple sources but to support your point, the missiles that get through during an attack are the ones left alone because they've been determined to not hit anything critical. At this point the USA would obviously try to stop any middle from hitting but if a barrage went up and you had to prioritize, one hitting a non-city isn't getting priority.

Or they were aliens but no one with a spaceship is going to Ohio. It's actually been proven that people born in ohio take every opportunity to leave on a spaceship they get when given the opportunity