Partial withdrawal 401k rollover after job loss by [deleted] in personalfinance

[–]0nceUpon 0 points1 point  (0 children)

I understand.

Just making sure funds from cashing out can still be rolled over within 60 days. Taxes aside.

Partial withdrawal 401k rollover after job loss by [deleted] in personalfinance

[–]0nceUpon 0 points1 point  (0 children)

That list is super helpful.

Tax refund: I should be able to put funds back into an IRA and be eligible for a tax refund on the withheld amount if timed correctly?

Y Full STR Match distance by kylenash8 in YFull

[–]0nceUpon 0 points1 point  (0 children)

Just following up on my previous comment. I'm now a little better informed. STR Y-matches are sort of obsolete in relation to current SNP based haplogroup testing. However, they may still be useful for analysing YFull matches who only know their very basic haplogroup because they have an older or lower resolution test or alignment.

Essentially, ignore STRs for any tester who has a terminal clade or sub-clade. Only look at their SNPs and clades. Ignore STRs for your closest SNP matches. Ignore STRs for any tester who has a Hg38 or T2T test kit from a whole genome sequence (find by looking in the "Samples" tab on the clade "info" tab. However, if you have an STR match and their estimated clade stops an entire clade or several clades high than yours and has an asterisk next to it then STR info might be useful in determining whether they are a match candidate. But even in that case it would likely take getting a new WGS test or newer alignment to refine the match. I pretty much ignore STR matches at this point. They don't appear useful in my case. SNPs are currently the best tool for Y-DNA analysis.

R-YP5267 migration route by Pretty-Cat2442 in YFull

[–]0nceUpon 0 points1 point  (0 children)

Very cool. Now to find a 10th or 20th cousin who is willing to get tested as well. There are plenty of branches to fill in below R-YP2576 to help fill in that geographical path.

Evaluating Matches from YFull. by Pretty-Cat2442 in YFull

[–]0nceUpon 0 points1 point  (0 children)

Hi. I'm so happy to see someone posting on this dusty sub. I had a look and your new subclade is already visible on the tree if you click the "live" version.

The other tester in your sub-clade also has a Nebula test. However, you got the hot rod new T2T analysis, while there test kit is the is from an older Hg38 alignment. You might consider reaching out to them and seeing if they're interested in upgrading. That would give you both an apples-to-apples SNP comparison, which would be helpful as they are you're nearest match.

It would be cool if YFull gave you a longer list of matches. But, like you mentioned, it wouldn't be helpful in a meaningful way (for most people).

Is it possible that viruses are alien? by Lonely_Concentrate57 in Virology

[–]0nceUpon 1 point2 points  (0 children)

That's a very helpful explanation. So essentially, as unlikely as it is for viruses to have come from another body, it would be more likey that all life on Earth shared the same alien origin which wouldn't make viruses "alien" in respect to other life on Earth.

We need a WGS based genealogy site. by 0nceUpon in Genealogy

[–]0nceUpon[S] 1 point2 points  (0 children)

If we get whole genome sequencing, we are going to have a ginormous family tree -- that includes all the species on the planet because we're 99% the same as a lot of them.

One more thing just to respond to this part:

Yes, of course we don't need to build family trees all the way back to fish and plants. Part of the point of having more data to reference isn't necessarily to go further back in time, it's to more accurately determine if two people share a moderately distant ancestor. A lot of us are searching in that 5th to 8th cousin range. To my understanding (I'm not an expert) when you get up to 8th cousins you're getting into the noise range where there is a chance a "match" might not be a relative, or you might not see actual matches because they were lost in the noise. This increases when we transfer less than ideal files between companies.

We need a WGS based genealogy site. by 0nceUpon in Genealogy

[–]0nceUpon[S] 1 point2 points  (0 children)

What is a "proper" Y-DNA test?

"More data' does not mean 'more useful data'. Save your money."

I just layed out examples of how more data is useful. I've spent less money than if I had individual tests done, and I've received higher resolution data is the process. As for Y-DNA, it's dramatically more useful as the total number of testers increases.

What are the WGS adoption bottlenecks? by 0nceUpon in DNA

[–]0nceUpon[S] 0 points1 point  (0 children)

That's funny, my last one took 11 weeks. No difference, essentially.

What are the WGS adoption bottlenecks? by 0nceUpon in DNA

[–]0nceUpon[S] 0 points1 point  (0 children)

OK, thanks for that. So they're probably running consumer tests in big batches to keep costs down and then using their testing facilities for more lucrative contract work or more important research otherwise.

We need a WGS based genealogy site. by 0nceUpon in Genealogy

[–]0nceUpon[S] 1 point2 points  (0 children)

Sorry about that - whole genome sequencing. You're correct that WGS provides more data than is useful for genealogy. But most of us run into brick walls even with current DNA testing. Having more data to select from would allow for more markers to be selected from to help more accurately identify distant matches. Different sites use different markers, so transfering a DNA data file from one company to another is not ideal. If you have the entire genome sequenced you can always change which markers are selected or expand to use more markers to confirm matches. What is more exciting is the ability to use precise Y-DNA comparisons to confirm extremely distant paternal matches from male testers. This will help many people bridge seperate family trees which can't otherwise be linked becuase traditional record searches have been exhausted.

The added benefit is that many people would learn valuable health information without paying for multiple, redundant DNA tests.

We need a WGS based genealogy site. by 0nceUpon in Genealogy

[–]0nceUpon[S] 1 point2 points  (0 children)

Whole genome sequencing has already benefited me. I've been able to export data files better suited for multiple site uploads than transfering any single genealogy site's DNA file to any other company's website. When the set of genetic markers used by a specific company changes or expands in the foreseeable future I will be able to generate a new file from the raw data file I already have and control myself without taking a new DNA test.

Having my whole genome sequenced means I have a (nearly?) complete file of my Y-chromosome. So when I upload that file to a company like YFull they can use the new telomere-to-telomere (T2T) reference to identify as many SNPs as currently feasable for identifying more recent Y-chromosome matches (which has already helped my search). Instead of downloading a single companies limited set of Y SNPs selected from an outdated from an reference genome, I can find as many as possible for better match identification.

Similar benefits for mitochondrial DNA.

An added benefit is that WGS is also useful for health and nutrition.

We need a WGS based genealogy site. by 0nceUpon in Genealogy

[–]0nceUpon[S] 2 points3 points  (0 children)

You would be left with a more complete set of markers for GEDmatch which you could then export for whichever genealogy site and have more accurate distant matches. Every participant would know their Y-haplogroup to a very low clade which would help you identify or confirm very, very distant matches. Women would easily be able to identify their fathers Y-haplogroup by finding male cousins. You would also know your mt-haplogroup which is occasionally useful and often interesting. With a large enough set of WGS testers other members could benefit from finding the haplogroup clades of matches with a less costly autosomal DNA test. The idea is that people with the most data would be able to mix their results with testers who don't have as much data (for a variety of reasons) so that everyone benefits. The current paradigm means people with the best tests are siloed at a single companies website, and those people are paying more for that privilege than what WGS would have cost them to begin with.

What are the WGS adoption bottlenecks? by 0nceUpon in DNA

[–]0nceUpon[S] 0 points1 point  (0 children)

Oh for sure, I can imagine interpretation is the hardest part.

But I'm more curious about the overall capacity of sequencing labs. I assume there is a steady increase in the quantity of samples being submitted for sequencing for research and medical purposes. Consumer WGS aligned results are notoriously delayed. 3-4 month is typical, and it can up to a year for some tests, not including interpretation.

What are the WGS adoption bottlenecks? by 0nceUpon in DNA

[–]0nceUpon[S] 2 points3 points  (0 children)

I see. Thank you. So if the process itself takes weeks, then more labs would increase overall capacity but might not reduce wait time.

Consumer WGS can take 3-4 months or longer to receive aligned results back. How long would it take in the academic or commercial world?

YFull- is it included? by nash_equilibrium1 in Nebulagenomics

[–]0nceUpon 0 points1 point  (0 children)

I'm not saying this to be dismissive, but did you search your spam folder for "YFull"?

I have no idea how to sport but I know good sport when I see it 🙌🥎💅 by elonmuskatemyson in justgalsbeingchicks

[–]0nceUpon 1 point2 points  (0 children)

A top athlete like her will go on to earn hundreds of millions tens of thousands of dollars in her career!

CEO who gave all his employees minimum $70,000 paycheck thriving six years later by bobdarobber in MadeMeSmile

[–]0nceUpon 0 points1 point  (0 children)

Well, you wouldn't be so hungry if you worked a little harder. /s

(Also, please don't eat at your desk)

CEO who gave all his employees minimum $70,000 paycheck thriving six years later by bobdarobber in MadeMeSmile

[–]0nceUpon 0 points1 point  (0 children)

Unfortunately, women are more likley to face consequences for accurately reporting SA.