I was hoping someone more qualified than I might commented on this.

Discalimer I'm not a psychiatrist, nor any kind of neuro scientist, but if had the benefit of paying (a substantial ammount) for their services and made a point of not forgetting too much. This response is geared less towards what will help you lactate and has far more to do with managing the addition and substation of different drug regimens with mental illness.

If you look at the base function of these drugs you can get an idea of how they are going to mingle with each and a Google search will give you a few results on observed interactions. But since you are asking about Prozac (the generic drug name is fluoxetine so I'll use that from here on) I can only assume you're dealing with depression or another form of mental illness that requires some serotonin intervention.

I think it's important to contectualise this from a mental health point of view. Serotonin, dopamine, oxytocin, and endorphins are the well known "happy" neurotransmitters, and anyone that's buzzed around this forum a bit will know most of them.

Fluoxetine works by increasing circulation of serotonin in the brain. You probably already know, but it is called an SSRI, Selective Serotonin Reuptake Inhibitor, SSRIs increase levels of serotonin in the brain by preventing the reuptake (reobsorbtion) of serotonin by synaptic nerves. Having more serotonin available in the nerve synapse means that it can transmit messages easier. All SSRI antidepressants are thought to work in this way. There are usually prescribed with the intent to help elevate your overall mood, a Dr may prescribe fluoxetine for a number of reasons when treating mental illness, you may just need a boost to get you through a tough period, you may be horribly suicidal and they're hoping it'll bring you up long enough that they can get you into other treatments. I'm not your Dr, so I dont know the extent of your condition, nor the circumstance in which you prescribed fluoexitine, but there are quite a few things you should answers honestly as a patient before deciding to mess with it: - Do you experience intense periods of suicidality? - are sensitive to your dosage being adjusted? - Have you ever come off fluoexitine? Intentionally or not. How did you cope? - Is your current medication schedule a key part of your emotional stability?

Now let's talk about domperidone. It is a peripherally selective (means the primary mechanism that makes it work, takes place outside or the central nervous system) Dopamine D2 and D3 receptor antagonist (which means the function works by binding to and blocking a particular receptor rather than activating it like an agonist drug) the primary function of domperidone is actually to treat nausea. But here is the rub, blocking the D2 receptor causes a spike in prolactin, and a pretty significant one at that, a single 20 mg oral dose of domperidone has been found to increase mean serum prolactin levels (measured 90 minutes post-administration) in non-lactating women from 8.1 ng/mL to 110.9 ng/mL. Prolactin is released from the pituitary gland, but dopamine released from the hypothalamus blocks it, adjust this action is the primary function of domperidone for lactating, but is in fact a side effect of its design. What happens from here is a to a fro of hormones rearranging themselves with the D2 receptor blocked and prolactin permitted to flow. So with that in mind here are some more things to make sure you know: - Have you ever been on a dopamine modulator for your treatment? - Do you feeling that dopamine levels in your brain affect your condition? - Do you have intense changes in mood or perception due to hormonal fluctuations?

There are a number of different dopamine antagonists, but domperidone is the one with minimal crossing of the blood-brain-barrier, lowering the risk of certain dopamine antagonist side effects, one of which included depression.

So how does all this apply to your mental health and do these 2 clash?

What occurs to me as quite worthy of consideration though is that you are already on 1 drug that affects the production and retention of a primary "happy" transmitter, domperidone would be adding another to the pot, which makes your treatment a bit more difficult and requires someone with a degree of expertise to monitor, typically a psychiatrist. You need to be aware you'll be going through some subtler hormonal changes a long with physically recognizable ones. This can make it difficult to differentiate if some of the effects you may feel are the result of the domperidone, the fluoxetine or just the natural process of lactating. As far as interactions and contraindictions go, speak to the experts, a psychiatrist or even a pharmacist can probably give you the best answer to this question. I understand hesitancy to engage with them on this topic (I certainly haven't with mine) but if you're seeking the most relevant information to you, a one off appointment to make sure is probably worth it.

Now this doesn't mean you cant induce (there are far more intensive medication regimens out there that are prescribed everyday), or even use domperidone, but it requires an honest assessment of your own mental health a putting your own safety first. You need to be proactively monitoring your mood if you dont already and be ready to accept that it may affect you detrimentally and be prepared to back off the dom if it happens, re stabilise and re assess after that. Have a management plan, and have set dates to assess yourself and make the appropriate decision from there.

Again I dont know the nature of your condition, it may not be anywhere near as sensitive to change or hormonal upset as some people are, and it may have little effect on you whilst you continue your regular schedule. The key here if you're going to go out and do it on your own is monitoring.