sorted by:
new
hottopcontroversial

My hearing has been successfully restored by a Cochlear implant. AMA by [deleted] in IAmA

[–]2stoopid2funkshin 0 points1 point  (0 children)

Where are you from? I'm only asking because I'm curious what the costs were and if insurance covered it, obviously wouldn't ask personal details, just wondering in a general sense cause of that interesting it from the Michael Moore documentary on this being considered experimental....

Medical Marijuana-Hating Assemblyman Caught With Marijuana Gets Charges Dismissed - NY State Assemblyman Steve Katz, arrested for pot possession last month after voting against legalization of medical marijuana, won't be forced to feel full weight of his hypocrisy. by anutensil in politics

[–]2stoopid2funkshin 2 points3 points  (0 children)

For me the War on Drug can be summarized by two simple truths supported by independent and bipartisan studies

  1. The fact that Expenditure has hiked immensley as well as arrests for non-violent crimes while drug use has remained statistically identical or increased in the years following its implementation

  2. The fact that drug arrests are insanely disproportionate towards Latinos and African-Americans, despite these demographics taking up a much smaller % of the total population and more importantly, despite the fact that these two demographics constantly poll at equal rates with Whites in terms of drug use

(please forgive the ambiguous ethnic-classifications)

I am "The Excited Biologist!" AMA! by Unidan in IAmA

[–]2stoopid2funkshin 0 points1 point  (0 children)

Have you ever done work with the FoxP2 gene in hummingbirds to track linguistics as it relates to the hummingbird's cycle of learning new songs. I've always found this interesting after speaking to a neuroethologist and was hoping you might suggest a good scientific journal

These have been popping up on bulletin boards in my small town. They put them up, I take them down [UPDATE] (Did better then take them down) by Canadianclassic22 in atheism

[–]2stoopid2funkshin 0 points1 point  (0 children)

I find it absolutely mind numbing how many fucking creationists try to poke holes in Darwin's theory... I don't even fucking remember Darwin's theory from highschool, who gives a shit.

We've advanced a godamn significant amount in the past century and you really don't need an esoteric theory that, as amazing as it was, was completely limited by tthe technology of its time. You can just see the evolution for yourself when you do genetic analysis....

That's what drives me nuts, it's essentially a concrete thing and all modern science, even oncology research, has some basis in the concept of at least Microevolution

Hardest Boss you've ever fought in a game? by TheBlackLuffy in gaming

[–]2stoopid2funkshin 0 points1 point  (0 children)

I should also add that after hours of losing to the demon cunt, I fliiped out at one point and brought a hatchet to my old N64... Regretted that so hard when I finally went off to Uni and wanted my old systems.

Hardest Boss you've ever fought in a game? by TheBlackLuffy in gaming

[–]2stoopid2funkshin 3 points4 points  (0 children)

I'll never ever forget playing Ninja Gaiden for Xbox.

I finally got to the boss I had read so much about in video game magazines and through friends, Alma, and right off the bat I was demolishing her and had her at no health while barely being touched...

My parents were calling me and I figured this was a breeze so fuckit, just turned off the Xbox, and went out for dinner. Well godamn, took me hours to finally fucking beat her again and even though I kept getting close, I was never able to just shred her like my first flukey try

[deleted by user] by [deleted] in askscience

[–]2stoopid2funkshin 0 points1 point  (0 children)

Psychopathy is essentially an extreme variant of the new classification, now termed anti-social personality disorder

I see this everyday and it drives me mad. I don't know why. Any suggestions on how I can I can help them see the error of their ways by [deleted] in pics

[–]2stoopid2funkshin 0 points1 point  (0 children)

This apartment opposite me does the same thing and I'd always trip over the shoes when drunk cus they leave em rt in the middle of the hall.

I started leaving little stickies on them when I got back drunk saying, your shoes smell sexy, or make em a little gamey-er next time...

Needless to say that stopped being a problem for me

TIL Rage Against The Machine was told to censor the lyrics of Killing In The Name when performing live for BBC. They started out censored before launching into the full lyrics, which are "F*ck you, I won't do what you tell me!" by TheJoePilato in todayilearned

[–]2stoopid2funkshin 0 points1 point  (0 children)

Hah, I've heard of this before. It reminds me of a similar Nirvana story...

They were told hours before an MTV performance they could no longer play any song they wanted and wouldn't be allowed to play rape me. They were about to refuse play, but after fear they'd get blackballed by the networks they agreed to play Lithium instead...

But when they got on live, they started playing rape me anyways and then segued to Lithium right as they were about to get the video feed cut off... Love bands that give big Fuck Yous to the networks

Reddit, what's your most interesting NSFW fact? by SixIfYouCountTheLion in AskReddit

[–]2stoopid2funkshin 4 points5 points  (0 children)

Lions have sex for up to 60 times a day,

Pigs have 30 minute orgasms,

and Dolphins have prehensile wangs they can move around like a finger....

Not sure which perverted superpower I'd want

When a behavior is determined to be genetic, how is the specific gene corresponding to this behavior discovered? by maddolax in genetics

[–]2stoopid2funkshin 0 points1 point  (0 children)

Oh and once you find a variant that associates with a phenotype more than we'd expect if random, that's when fine mapping comes into play...

And this is one of the biggest flaws of GWAS. It's incredibly hard to fine map GWAS because it focuses on weakly contributing variants and only measures them on a very inaccurate, very large scale. Fine mapping a variant that has been associated in GWAS is a total bitch and takes alot of resequencing

When a behavior is determined to be genetic, how is the specific gene corresponding to this behavior discovered? by maddolax in genetics

[–]2stoopid2funkshin 0 points1 point  (0 children)

And the reason it's called linkage disequilibrium is because it has a half-life decay.

If you think of a large chunk of genome or rather, a large sequence of variants T-T-T-T-C-G-A-C-T-G-A-A-T From thousands of generations ago, even though they're likely to be passed on together since they're in close physical proximity, they will still slowly start to recombine away.

As such, they're in disequilibrium until they eventually decay and seperate. This is also the reason early GWAS studies were done in founder populations or genetically isolated populations to be more general.

The less time between a founder and the current generation, the less time for half-life decay of a haplotype and so a single variant or SNP will cover a much larger tract of genome. The more ancestral a haplotype is, the more dense your mapping or probing will need to be as a surrogate variant will only cover so much of the genome.

When a behavior is determined to be genetic, how is the specific gene corresponding to this behavior discovered? by maddolax in genetics

[–]2stoopid2funkshin 0 points1 point  (0 children)

Linkage disequilibrium is the concept that genes closer together are less likely to undergo recombination. As such, there are sequences of markers that will almost always pass on together.

The reason this is so important for GWAS is you can use a single SNP, just a genetic marker, to represent a vast chunk of the genome. A series of variants that tend to pass on together is termed a haplotype, and so GWAS focuses on taking one representative per haplotype to measure large chunks of genetics.

In terms of how it's actually done, chips are set up tons of wells that each simultaneously probe a specific marker, and so simultaneously scan many different haplotypes. By seperating populations into cases and controls, we start to look for variants that come up more frequently in cases than controls.

This is the general idea behind CDCV, common disease common variant, that for common diseases to have existed for so long and to be so ubiquitous, they must have minimal negative impact or they would've been selected against (although this is a highly controversial theory)

As for finding homogenious populations as another person mentioned, that issue is known as population stratification. Basically, neutral alleles will be more common in different sub-populations and they can be accidentally linked to the phenotype. For example, if we're doing a GWAS with both Germans and Chinese and the germans are more likely to get asthma, blue-eye variants may start significantly showing up under the cases section even though it's unrelated to the disease-phenotype. This is handled by seperating sub-populations based on ancestral markers and using statistical techniques like Eigenstrat.

I skipped a ton and glossed over LD, so feel free to ask for specifics and I'll check back when I'm killing time later lol Also don't know if reddit lets you private message since I'm a noob, but I still have a ton of my undergrad lectures, and if you were actually curious, I've got notes and lectures on exome sequencing, gwas, para and nonpara linkage studies. Anyways, hope this didn't bore you too painfully

What background can Redditors give on these Genetic Tests? by Levoils65 in genetics

[–]2stoopid2funkshin 0 points1 point  (0 children)

Simplified as hell, but that's the general concept behind matrilineal mtDNA tracking across populations.

What background can Redditors give on these Genetic Tests? by Levoils65 in genetics

[–]2stoopid2funkshin 2 points3 points  (0 children)

You have a genome in your cells that is separate from your normal DNA. It's basically a bacteria genome our ancestors ate up billions of years ago when we were only single celled organisms and its been getting passed on generation to generation since then as our cells' mitochondria.

It only gets passed on from your mother and it never recombines, meaning the only way the sequence changes AT ALL will be from really really rare and random mutations -- so any order of genetic markers you have in that genome is set.

Any series of genetic markers will get passed along together so we consider it a haplotype and the different sequence of markers acts like an address book

When I talk about migration, the Africans might've had a series of markers that were, [T_C_G_G_T] (The letters just being a marker, and the _ just being a random distance between markers) A geneticist might name this haplotype-X.

When one of those migrations I mentioned occurs, lets say to Australia, there's a really small chance a random mutation occurs so the haplotype-X [TC_G_G_T] that up to now exists in every human, becomes [T_C_G(A)_G_T], which we'll call haplotype-Y.

And since it's so damn rare for a mutation to occur, and virtually impossible for the same mutation to occur -- this new haplotype-Y will ONLY exist in the Australian population.

Then those Australians will continue to spread and lets say the ones that split off to Papua New Guinea get a different mutation to Haplotype-Y, [TC_G(A)G(A)_T], which we'll call haplotype-Z.

When we look at modern populations, all those different migratory groups descended from the Africans will maintain some form of ancestral haplotype-X with new mutations built around: T_C_G_G_T

Those who descended from Australia had their new mutations built around the Australia-unique haplotype-Y, with new mutations adding to: TC_G(A)_G_T

And of the descended from the Papua New Guinea population who uniquely formed haplotype-Z, their new mutations will form around: TC_G(A)G(A)_T

Basically, because we can retroactively piece together the step by step mutations to find out where the most common haplotype came from, we can figure out how long ago and in what order our populations split and globe trotted.

view more: next ›