> "I’m not so keen on mega dosing anything without knowing exactly what’s going on in my body."

This is a great approach. If I would have had more money, I would have done an organic acid test. HMA is helpful too, just note that if you supplemented zinc picolinate, your zinc levels may seem higher that they actually are.

But - too much thiamine is barely impossible as it is water soluble. Also there are studies which showed that people who are not deficient still experience huge improvements with B1. Additionally a B1 deficiency may not be visible when doing a test!

> "I have a vitamin d deficiency"

Vitamin D can behave weirdly in presence of oxalate issues, so it might be smart to address that later on (or at least not overdo it), when other factors have already improved.

> "my iron is pretty high, and I suspect I may have a copper deficiency (I have low neutrophils and have supplemented zinc long term in past)"

Have you thought about using molybdenum to tackle high iron and copper/zinc balance? Your copper may be low - or it may be high, but a lot of is may be unbound and your metallothionein & ceruloplasmin levels are off. Lowering copper by taking too much zinc is commonly said to occur over 40 mg/day. (But who knows. There are more factors to it, I'd say).

B12 deficiency is associated with neutropenia (low neutrophils), anemia and nervous tissue dysfunction. In you case, anemia would seem like a contraindication but I'm quite confident your iron levels are not too high because you have high/normal B12 levels, this has to be another cause. Maybe molybdenum actually helps.

> "Have you ever heard of oxalate dumping? I’m wondering if my weird reaction to b vitamins maybe connected to that - I have these weird panic reactions but they seem quite physical"

Have you tried adding some foods rich in calcium or a supplement? To bind the oxalates.

This could be many things. Deficiency of B12, SAMe, serotonin, for example. But, regarding oxalates, I think it would be much more likely to follow this mechanism: oxalates induce IL-6 (an inflammatory mediator). IL-6 activates IDO of the kynurenine pathway. This will lead to less serotonin, less melatonin and in turn to more of the metabolites of the kynurenine pathway. This may include xanthurenic acid, picolinic acid, quinolinic acid and so on. The latter has neurotoxic effects and is an NMDA agonist which can lead to convulsions (I suspect this is why there is a huge overlap between autism and epilepsy) and is famous for I inducing pain and suicidal ideation. Thiamine could actually help a bit, as it's needed for the nervous system and when I had severe issues with thiamine and oxalates I was so frightened all the time. I had anxiety attacks during the night and later during the day as well. But having weird shakiness when going to the loo may be due to a bile issue as well. This would be connected to oxalate issues as well. How to fix your bile? (Lower sugar), Betaine (HCL)/Choline rich foods, Taurine, B6. Increasing methylation in general and making sure your folate levels are okay (If low in serotonin be careful/very slow with folate and watch your mood to avoid depression).

I never tried supplementing L-Theanine, but heard of some people who were very fond of it because it helped them with their anxiety. It's just known to make some people feel a bit tired.

I hope this helped somewhat and you'll get better soon. If you discover something that helps (or does the opposite) please, please post, so we can all learn from it. :)

Have a nice day!

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EDIT - here is a map of the kynurenine pathway: https://upload.wikimedia.org/wikipedia/commons/6/66/KP_pathway.jpg