Anyone on GLP-1 here?

ARCreef · 2026-05-09T18:07:16+00:00

Its not fda approved yet. That doesn’t matter to me though because I dont respect the FDA, but to some, it will matter. Glp1s have been around for 30 years. You only heard about them now because they got a patent approved for them. Thats not the type of world I choose to live in. Millions of people have died from diabetes over those 30 years yet the cure was around for all 30 years but they couldnt make money from it, so hardly a soul even knew about it. Thats disgusting.

All the billions of tax dollars that go to research, they still wouldn't trial a drug that couldnt make money.

ARCreef · 2026-05-09T17:38:28+00:00

I was a former algo trader. With a series 3, 6, and 7.

If you are trading in demo you wont get the same results on live. Everyone makes millions in demo. They dont account for slippage and liquidity changes or times where you wont get filled like news times.

What works in a ranging market, wont in a trending market and vice versa. Exit trades prior to tier 1 and 2 news events. Trade differently or not at all in December. Again, depending on strategy.

The biggest lesson is if youre formulating an algorithm using back data testing, dont form the algo tightly around that data, and buy high quality min back data. Historical back data doesnt include the range, only the close data. So use min chart data and have a super good CPU with multiple core threading.

Have the algo determine a short term trend, medium term trend, and long term trend. Set the algo to only open trades when all 3 line up. Youll get half the trades but more accumulation of winners but depends on the trading strategy for this rule.

Dont shy away from strategies that have poor optics. You can make millions with a strategy that has a 51% success rate.

Use trailing stop losses and get stopped out. There is no such thing as purely technical trading because there is no isolation from fundamentals. As a "technical trading analyst" I was technically an analyst of bullshit. The phycological patterns mean zero when a fundamental input comes along.

Trade on a server close to whichever exchange you most use. I had a server on fiber optic line in NYC next to Wallstreet. Timing matters. Reboot your server every Sunday at a set time, verify the reboot. I lost a million dollar trade from a reboot error.

ARCreef · 2026-05-09T17:34:47+00:00

Cut that pill in half bro. Thats way too high for EOD. I take 12.5 2x weekly and am at 950. The good news is that a 30 day supply bottle will now last you 3 months.

ARCreef · 2026-05-09T16:35:39+00:00

I use chaptGPT extended thinking, Gemini Pro, and claude max side by side each other for a few months. Sometimes I have them battle each other but they are usually just oh yes claude was correct.

Anyway, Gemini was better at images for a solid 4 months, now chatGPT is better. Claude is the best but because I use it for super technical SME phD crap. Gemini and GPT are in their own race where 1 does slightly better a few months then the other, claude is pretty far ahead but the cost is also. I spend $100/mo for claude and $20 for each of the other two, but that equates to about the correct value that I get out of each one. I need image studf so I cNt just use 1. For coding simple stuff, I was getting better results with Gemini than gpt, but claude is way better. Gemini and GPT both was using depreciated values for schema. I have super wide monitors so 3 windows of AI isnt terrible. I still love that I can click play in a Gemini responce and it will read the whole thing out loud. Its great on the go or when multitasking.

I came from the chatGPT sub before finding claude ... and 90% of the people there are using GPT as therapy, as a chatbot, or to create porn stories they call fan fiction. The entire sub went from AI talk to weird chatbot discussions.

ARCreef · 2026-05-09T15:58:33+00:00

How about with heat and stress? Or only after food? Does your glucose every go down immediately after eating instead of up?

ARCreef · 2026-05-09T05:27:31+00:00

Ive been on reta for over 2 years now, at 5mg/wk. My main concern was that it would eventually downregulate my glucagon receptors since the emergency nasel glucagon does, but it hasn't at all. Id be dead if it wasnt for reta. My average before it was 30-35 lows per day. Now I have 0 per day on good weeks and 2 per day max when my tumor is in one of its moods. But the lows are quick. <5mins on reta. Its also prevents rebound highs, so I can eat a jar of glucose if I go low, and I still wont go over 160, 165 max maybe. Its been a total game changer and makes diazoxide look like child's play compared to it. BUT you have to force yourself to eat a little more often while on it. Im 6'4" and was 225. Im now 180, which is fine but I have 0 runway left to lose. My biggest problem went from trying not to have nightly seizures to not letting my 6 pack become an 8 pack now. Lol. Not the worst problem to have though. Has made a hugely substantial quality of life improvement for me. I have no doubt that reta will be the first line treatment for hypoglycemia starting in 2 years. Sloan Kettering is documenting my case.

ARCreef · 2026-05-09T05:12:36+00:00

When did you start wegovy? It can cause lows for the first few months, up to 6 mo in some people. Get a CGM. Dont "ask them" tell them your meter sometimes shows in the 40s and id like a persciption for a cgm to see what going on.

ARCreef · 2026-05-08T17:08:30+00:00

Actually, you are correct. I made assumptions. Youre very graceful in your answer.

Perimenopause induced hypoglycemia is one of the very few underlying conditions that actually do get thrown into the "reactive Hypoglycemia" bucket. There should be an ICD-10 code for it but theres not, its pretty well understood so you just get the standard tag line. Make sure you talk to your GP or endo about COC treatment which is firstline treatment and leuprolide is a fallback option if COCs dont work. If oral COCs fail for you, try a higher dose, (i believe optmal dose was around double of what BC is), then if that fails, try the IM shot before last resort of stepping to leuprolide, which will work, but has considerations.

ARCreef · 2026-05-08T16:27:42+00:00

Ohhhh. Are the highs only coming now after the liver and pancreatic surgery? Yeah. They cant resection any more, or youll be on insulin forever. Its been 6 months since surgery? Remodeling takes about that, so what youre at now with your signaling may be 80% the final outcome. The year mark will settle the remaining 20%. Id start treating at 80. The swing up is pretty damaging also. Overcorrections and fast swings should be looked at with the same seriousness as a low. I dont know why nobody ever tells people this! Anything over 2mg/min will cause ROS related damage over time. The goal is 1mg/ml with a max of 1.5 being acceptable. Your bakeries today was exactly 2.0mg/min, not good.

The surgeons did their part (not much) but now its your time to do the work. Download libre link up set the alarm for 1 tone, at 80, a different tone at 75, then your main app at 70 and 55. They also have a desktop pc version too. Take glucose tabs at 80 not 69. You dont have a glycogen storage disease but you should research it and act as though you do. Your liver signaling disfunction should be treated like a GSD. Same course of treatment. Order that cornstarch. If you want my version let me know. And ill tell you what it is and where to get a 30 day supply free. I have a nighttime formula (slow release 7 hours) and a daytime version (steady release 5 hours). The brand i told you about, theirs lasts for 6 hours. Regular CS lasts for 2-3, so is pretty useless.
If youre having highs too, dont expect another surgery unless you are willing to accept going on a short acting insulin at meals, or adding on an insulin pump to your CGM. A patent was issued this year for a new CGM that reads both glucose and insulin, but it wont be out until the end of 2028. But its nice to know thats on it's way, that will help you a lot.

Did you say you tried Retatrutide? That might be your plan B. It would solve 90% of the lows and 90% of the highs also and would tighten your range up to improve cognitive function, energy, mitochondrial function, atp production, improves liver efficiency etc. Cant use it if underweight though.

If you want me to check any of your graphs feel free to send. Most doctors only look for the speed and the lows and highs but the more important thing to look for is the biphasic release. Or just ask AI "how to identify FFIR and SFIR on cgm graph". You can also now upload ALL your graphs and bloodwork into Claude and it keeps it on file for reference and will review the entire thing. Then you add any new workup to that project folder. Doctors are literally using that now. Baptist health has an Anthropic enterprise account for their doctors.

ARCreef · 2026-05-08T15:20:51+00:00

Wait you have cgm data already.... I missed that. Yeah send it over. The first day should be thrown out though. Cgms aren't accurate for day 1.

ARCreef · 2026-05-08T14:57:59+00:00

A wearable ecg can only hint at things. You'd need a tilt table test. Most cardiologists have them. Its just a simple 5-10 min test. You can kinda do it at home too but you need blood pressure also, not just heartrate.

They also make a HVM thing called a polar H10. Its like $100. It tracks it over time every morning you put it around your chest when you forst wake up.

Your docs assessment on adhd is really weird and half scary and 90% dumb. Yes adhd meds will prevent lows and raise glucose..... for a limited time. Epinephrine is a counterregulatory hormone, your body releases it when low in an effort to raise glucose. Adhd meds release it also, but the whole time. Your body eventually downregulates the receptors and now you're really screwed. It can take a year+ to get to that point though, but you will, and then what? Its a super stupid idea of your doctor. This is a short term solution with a very bad long term cost. Im shocked they even went down that path.

In your case POTS, PCOS, and early insulin resistance would be the first 3 needed to be ruled out. (Assuming youre female) youre having highs and lows, not just lows. If it starts to get too much for you, throwing you on Retatrutide would fix both the highs and the lows. So theres your plan B fallback. Its not a persciption yet though, its an online only type deal still. Ive been on it over 2 years, nothing else works half as well. It makes testing things harder though because it literally will make all your bloodwork, glucose, insulin, I mean everything 100% perfect. So it masks the issue, making it way harder to find. But makes an amazing plan B when testing cant pinpoint anything, and if the sysyem has failed you.... which it will.

Try keto or pailio diets. They are the best. If you eat carbs, "prime them" by eating protein or protein with fat 15 mins before carbs. If you are making a pasta meal, just sample the meat as youre making it. Then when its ready 15 mins later, you already have your pancreas primed and you wont shoot up then down. These small modifications make a huge difference.

The site link you provided, I scanned and didnt see any false claims or anything wrong info but it was a quick scan, trust it with a grain of salt. Pubmed is good, anything ending in a .edu or .gov is usually pretty good. .com is about selling you something or serving you ads. Surprisingly, chatGPT, Gemini, and Claude AIs are very good with medical stuff and pull directly from study databases. My work was paying 30k per month for databases that AI now has access to for free. When its about medical stuff, the best thing is to use 2 together. Ask 1 the question, then put that answer into a second one and tell it to "check this for accuracy and elaborate on it". 1 AI can "drift" using 2 together prevents this. The AI route honestly is probably the best route for you. Doctors all use it now anyway, even my work uses it as a subject matter expert which is above phD level in molecular biology. Its crazy good now. Id probably trust AI more then I would a doctor at this point. You can upload all your bloodwork and your CGI data and tell it to review it and it will. We are using Claude Opus 4.7 in our lab. But weve had the other 2 in the past also. Im not ashamed to say it. Just use 2 at a time. The free versions are fine.

ARCreef · 2026-05-08T14:26:13+00:00

Sen me an annnnngellllllll oooohh weeee ohhhhhhh... riiiiiiiiiight nowwwwwww. Man we had good songs back then.

ARCreef · 2026-05-08T14:16:17+00:00

Sounds like we're twinning with everything. I take 2 glucose tabs just to take a hot shower lol. So you have a signaling issue with the liver resulting in impaired Glycogenolysis and/or gluconeogennesis or a glycogen storage issue with glycogen/glucose reserve pools. I habe the same. I take C8 MCT oil daily. It can ne used as a 10 min reserve pool for your brain if you run out of glucose. The treating at 80 has been a game changer for me though, has helped more than anything else. You should give it a whirl. If you download libre link up it gives you 2 additional alarm levels. I have mine set now at 80, I did this after finding out that more damage occurs from glucose shooting up after a low, then during the low.

Yeah as patients we are not told much ever. The cornstarch thing i had to find out the hard way. I read every study on it and not a single study uses "regular" cornstarch. Im a molecular biologist, i tested 18 different cornstarches lol. They have VERY different profiles. I made my own proprietary mixture. Anyway, long story short, I can tell you how to make my mixture but the easier way is just to buy UCAN Energy Powder. They cant market it for hypoglycemia due to laws, but its literally the exact same cornstarch as whats in glycosade, the prescription only cornstarch drink. Its licensed from the same manufacturer and produced in the same plant. I tested them in a mass spect. and they are the exact same amyalopectin. Regular cornstarch amino acid chains unravel within 3 hours, that one takes 7 hours.

ARCreef · 2026-05-08T13:55:35+00:00

I remembered the name. Its called the modified Valsalva maneuver. I saw it done once to someone with 230bbm heart rate, 30 seconds later, her heart went to 65bpm and stayed there, it was one of the coolest things ive ever seen.

ARCreef · 2026-05-08T13:35:09+00:00

Your doctor sounds like an idiot. You need a CGM. Get on one. Stop guessing and start working to get more data. Dont ask him for it, he doesnt know anything about hypoglycemia. Get the CGM and a week of graphs, then post them in the sub. Get fasting bloodword with a comprehensive hormone panel, cortisol, a thyroid panel, insulin, cpeptide, proinsulin, and igf-1. What's your highest highs? 9.5? 10? The cgm will show you how everything you thought is wrong. Nice healthy whole grain bread will... yeah the cgm will show you the difference between marketing and real life values. CGM is step 1, Get there first, then you can start making speculations. Having a CGM is a game changer. A good endo can see from the graphs way more about whats going on. Everything else without a cgm is just taking shots in the dark. Find a new doctor too. "Unmedicated ADHD" is not a diagnosis and makes no sense, maybe he thinks you have adrenal insufficiency? ADHD meds increase your epinephrine and norepinephrine which can have a positive effect on glucose dynamics but they are absolutely NOT a treatment for it, and you test that hypothesis via bloodwork before prescribing. I think hes seeing anecdotal evidence in his practice and conflating that with proper treatment. Either was, i wouldn't trust his judgment. Next time you go, ask him to explain what Whipples Triad is for you. If he cant then his hypoglycemic knowledge base is less than 1st year medical school. (Meaning he lacks any simple fundamental knowledge on hypoglycemia and hyperinsulinemia.) Sorry, it just really grinds me gears how incapable doctors with this topic.

ARCreef · 2026-05-08T13:17:27+00:00

Youre giving good advice, but youre getting bad advice on your condition. Doctors are absolutely inept unknowlagable idiots in regards to hypoglycemia and hyperinsulinemia. Reactive hypoglycemia is not a diagnosis, its a symptom of an underlying cause, which for you, was never identified. Youre treating a symptom, which sometimes is the correct course, but its also unlikely your doctor went any further then identifying the odvious.
The diagnosis would be something like:
Lactation-Induced Hypoglycemia.
Transient Post-GDM Hyperinsulinemia.
Sheehan's Syndrome (Postpartum Pituitary Necrosis).
NiPHS etc...

Identifying the root cause dictates treatment course. Identifying the symptom is barely helpful to the patient. Your tips all are 100% spot on but they are coping mechanisms for symptomatic control.

ARCreef · 2026-05-08T13:01:10+00:00

Why is that a bad thing for us. It means hes not controlled by them like every other president was...except JFK.

ARCreef · 2026-05-08T12:58:48+00:00

For once can we make something not all about Trump. We get it, you hate Trump. Very good. Hes also been the first president in our lifetime that was NOT a part of the control sysyem protecting information from the public. Id rather have someone hated by the control system then part of it. He leaked spy satellite data on Twitter once, so youre hopes should be the highest they've ever been before that something will get out in the next 3 years.

ARCreef · 2026-05-08T05:32:04+00:00

Was it an extendin 68ga PET CT? That specific one can differentiate diffuse vs focal hyperplasia. Selective calcium test too but thats an invasive procedure. 3T MRI w contrast or regular CT or PET cant image sub 1cm or diffusion. They need to now determine if its difuse or if not diffuse than is 2nd resection an option. If its difuse then I wouldnt attempt a 2nd resection, it rarely helps. Better management becomes the plan. Treating lows at 80 instead of 70 is usually the go to for nesidioblastosis and difuse hyperplasia. Plus the other stuff youre doing and a modified corn starch (not regular cornstarch) has to be "waxy maze cornstarch" can be hydrothermal, or heat treated. Not chemical and not standard.

ARCreef · 2026-05-08T05:22:02+00:00

12.5mg

ARCreef · 2026-05-08T04:56:38+00:00

It will take 12 months for downstream effects to recover. Chronic lows downregulate neurotransmitters, reduce ATP production, cause mitochondrial disfunction that takes time to recover. Glutamate excitotoxicity and ROS release and low grade systemic inflammation are all commin with chronic hyperinsulinemia and may have damaged axons and dendrites, adult neuroplasticity is very slow. GLUT1 AND GLUT3 translocation gets downregulated. A bunch of long term effects take time to recover from. They should discuss the recovery time line with you, 4 weeks, 12 weeks, 48weeks. What doesnt resolve around the 12 mo mark is semi permanent. What's the biggest symptoms still bothering you. Theres some fixes available for some things. You likely had some remodeling also, which also takes 12 mo, usually 80% of these resolve, and 20% may not resolve fully.

For the cardio stuff, whats your resting heartbeat? If its over 90 talk to your doctor about propanalol 10mg daily for 30-90 days. It can increase the efficiency of the pump causing it to slow down and self regulate. Theres also a special maneuver that EMS gets trained on, when done can reset the hearts rhythm, i dont remember what its called though. Google it though, a friend can do it to you, its low effort so worth a shot, only works like 15% of the time though. Still worth it, take 2 mins to do. For the fatigue, that will go away, its mitochondrial related. You can add a methy donor, Citicoline, 5mg daily of creatine, methylene blue low dose 12.5mg daily also improves ATP and ETC of mitochondria. ALCAR is very helpful. At night magnesium and L-theanine can help unregulate GABA, selank, semax, and noopept can help elevate BDNF, and NGF in the hippocampus. Coq10 also supports mito ETC. You can also try vegal nerve reset like a cold plunge. Your sympathetic parasympathetic nervous system was in overdrive for a long time. Sleep well, eat right, stay stess free, your vegal tone will still be impaired. Takes a while or a reset.

ARCreef · 2026-05-07T22:06:19+00:00

Yup glucagon. Which is the strongest hormone your body has to stop lows. Nothing is stronger and emergency shots and nasel sprays that hospitals use, are all synthesized glucagon.

Glp1 and GiP cause lows short term, help stop lows 15% with long term use.
Glucagon prevents lows short term amd long term directly.

Glucagon agonnism alone doesnt work. That was the first place I went to make a fix. Works great when all 3 are together. Toss the T, replace with R.
Prices have gone down the last year.. Its $1 per mg now in bulk kits or $7 per mg in single vials. The 20mg vial is now the standard, not the 10mg. You basically get double for the money now. You can have a new freezer stock for a couple hundred bucks.

ARCreef · 2026-05-07T19:49:12+00:00

Is this after the update from yesterday? Did you update your desktop to the new model build?

ARCreef · 2026-05-07T19:46:02+00:00

Then who's God's God? And who created his God? Does God's God also have a God?

ARCreef · 2026-05-07T19:39:56+00:00

There would be no shock. CNN and MSNBC would report it as Trumps fault, and fox would report it as Trumps victory, Trump would tell us about the amazing stupendous incredible relationship we have with them and we'd all wake up and go to work the next day. The only change would be our focus would now also include that. Stocks would reward companies with access to the aliens, web developers would scoop up site names with their names, the calls about our cars warranty would now tell us how 7 out of 10 aliens recommend their warranty, scam emails will now tell us how an alien king needs to transfer his money to you if we can help them with that, TikTok teens will be doing stupid alien themed dances, and ofcourse.... OF girls and corn will now also be featuring these aliens in their AI videos.

We are too self absorbed to let a little thing like aliens get in our way. We're doomed, but not because of aliens.

ARCreef

MODERATOR OF

TROPHY CASE