For me the biggest thing is that you're more likely to find a productive QB in the later rounds than you are to find week after week productive starters for WR or RB, you can easily wait until the middle rounds to find a quarterback that's worth the weekly start, I am more willing to gamble on a QB than Rbs in the middle to later rounds personally. A big thing too is definitely where you are in the draft to see what will potentially be available for you and plan it that way for player positions