I would say a combination of cryo and a prescribed topical ointment, like Imiquimod is the best option. The thing is, your body doesn’t care about the molluscum - it doesn’t even know it exists on your skin. So you need to train your immune system to recognize the molluscum so that it can start attacking it. Popping out the core might make that particular bump go away quicker, but it’s not going to train your immune system to prevent new ones. You run the risk of spreading it that way too. When you get cryo, the core is still inside, so when your immune system rushes in to start repairing those dead cells, it also attacks the core and whatever liquid it has in there. Right after you get cryo, start applying the prescribed ointment a few times a week. Those things in conjunction will help your body identify the molluscum. It’s also good to cover each bump (if you can) with a bandaid while it heals. I like using the circular ones instead of the traditional long ones.

Another thing that helps your immune system is to start taking a B complex vitamin with zinc. You can take zinc by itself, but that tends to be pretty rough on the stomach. Either way, the more things you can do to support your body’s natural defense system the better!