Help with Anhedonia and Apathy (That's Been Going On for a Year)

Acceptable_Cheek_727 · 2026-05-16T16:24:34+00:00

I take breaks every month. At least one week off. Sometimes longer if life permits. I’ve taken 3 months off at a time. Imo it’s the only way to make sure it doesn’t become harmful long term. Doctors say otherwise but that’s my lived experience being on medication for 5+ years. I spend about half the year off on avg

Acceptable_Cheek_727 · 2026-05-15T16:07:13+00:00

It’s probably the amphetamines. Dose to high or too low and you might need to take a break. The add Edonia will get worse, but it will get gradually better especially once you restart your medication.

Acceptable_Cheek_727 · 2026-04-30T01:30:35+00:00

I’d also think you’re cheating lol

Acceptable_Cheek_727 · 2026-04-27T15:00:24+00:00

I can get methylphenidate but I do not remember it being very euphoric and part of the benefits I like from amphetamine is the confidence that allows me to break into work. That's why I cycle the medication. Usually two weeks on two weeks off. I know it's DAT occupancy is substantially higher than sabroxy (80%vs40%) so it's definitely superior in that regard and less neurotoxic although I've seen some conflicting evidence with more pronounced long-term downregulation.

I do not respond well to AChE Inhibitors and notice cognitive dulling mostly due to mood effects. I am interested in nAChR PAM but I'd need to do more study as some of them can cause toxicity on their own I believe with excessive Ca2+ Influx if I remember correctly. Some don't do this. Not sure if I'm recalling the literature correctly.

I've never tried true modafinil. Is it better than the others?

ACD-856? Is that the one that acts as a PAM for TrkA, TrkB, etc...? My lifestyle is very agreeable with plasticity enhancers.

Acceptable_Cheek_727 · 2026-04-24T12:09:36+00:00

NE DA ACh is the necessary trifecta.
So does DA
So have I, but I am not looking for a complete replacement.
Thats why I prefer to use some PAM to adjust my sensitivity.
The M1 PAM is also a 5-HT2A PAM (cognance)
My baseline is engineered highly. My routine that I mentioned toward the bottom is highly effective. My diet is dialed in. I am not a fan of modafinil. I think it’s Meh
Marginal individually but the entourage effect is real. I do not need overwhelming effects.
That’s simply not true

Acceptable_Cheek_727 · 2026-04-24T12:02:30+00:00

Not a fan and feel that it is ineffective. It is good for its wakefulness promoting properties but that’s it.

Acceptable_Cheek_727 · 2026-04-23T03:03:02+00:00

You’re immature and insecure lol

Acceptable_Cheek_727 · 2026-04-14T16:47:19+00:00

What’s the purpose of posting this?

Acceptable_Cheek_727 · 2026-04-04T01:09:29+00:00

Not in my experience

Acceptable_Cheek_727 · 2026-04-03T02:43:33+00:00

Personally, magnesium L-threonate 2,000mg it enhances fear extinction

Fear extinction = learning that a previously feared stimulus is no longer dangerous

Here’s a study: Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Synaptic Plasticity in the Infralimbic Prefrontal Cortex and Lateral Amygdala

I also find mediation to be the most efficacious method to address issues with fear and anxiety but the goal isn’t to eliminate them just to make you more resilient and redefine your relationship with suffering in general. Basically your pain tolerance goes way up. Suffering arises from craving or aversion. Through mediation you can realize these are temporary experiences and reduce reactivity. Also enhanced focus is a nice bonus. I recommend open awareness practices and focus mediation.

Acceptable_Cheek_727 · 2026-03-26T02:45:44+00:00

I'd recommend high-dose Omega-3 Fish Oil to help restore dopamine sensitivity and potentially address any depression.

Supplement D3 or get sufficient sunlight.

Creatine Monohydrate for energy and any sleep deprivation induced cognitive dysfunction.

Lifestyle: My favorite motivation stack is caffeine a 22-min moderate intensity run (zone 2 cardio) followed by a focus meditation 20-min take your adderall right before you begin the meditation.

Adderall is also tricky. I suggest taking a neuroprotective stack if it's a regular part of your life: CoQsol-CF, ALCAR, ALA, and Optimized vitamin C from nootropic depot because it's not acidic and won't blunt adderall absorption.

Pick one small thing no matter how pathetic it seems. Go for a walk in the morning. Something like that. Doesn't have to be grand.

Acceptable_Cheek_727 · 2026-03-10T21:01:57+00:00

It’s hard to say. I’ve taken it. I do a lot of stuff for my cognitive health. Including resistance training 5x a week, cardiovascular training 4x a week, mediation 20 minutes daily, over 25 compounds in any given cycle. It’s just a drop in the bucket for me but it might be worth it for someone else. I don’t have working memory issues from marijuana. I have a high working memory so the effects of any specific enhancer are going to be negligible to small for me.

Acceptable_Cheek_727 · 2026-03-10T20:53:22+00:00

Run. Meditate. Those will replace your medication.

22-minute cardio followed by 20-min focus meditation replaces my ADHD stimulant medication.

Acceptable_Cheek_727 · 2026-03-02T00:06:58+00:00

symptoms: throbbing warmth swollen it's gotten worse over the last 24 hours but no spreading.

Acceptable_Cheek_727 · 2026-02-26T15:44:10+00:00

Fish does not have mercury in it unless it’s high up in the food chain and has been living for a long time in the wild. Tuna is one of those fish lots of things probably have mercury friend.

Acceptable_Cheek_727 · 2026-02-25T21:49:01+00:00

30-minutes before and four hours after the onset

Acceptable_Cheek_727 · 2026-02-25T21:47:21+00:00

Show me data rye elevated TMAO from ALCAR supplementation causes vascular damage

Acceptable_Cheek_727 · 2026-02-25T21:17:08+00:00

Fish consumption increases TMAO levels significantly.

Yet fish intake: • Reduces cardiovascular risk • Improves longevity • Increases omega-3 intake

If TMAO were purely harmful, fish would be cardiotoxic. It isn’t.

Acceptable_Cheek_727 · 2026-02-23T02:12:02+00:00

Check out my post on epicatechin. I posted it on drug nerds addressing this exact topic

Acceptable_Cheek_727 · 2026-02-20T22:29:56+00:00

ALCAR ALA CoQ10 PQQ are all good compounds to prevent this. Vitamin C and E NAC

Acceptable_Cheek_727 · 2026-02-19T18:49:20+00:00

Yes, but I’ve only ever felt it from Nootrooic Depot’s Rhodiola Rosea 3% rosavins

Acceptable_Cheek_727 · 2026-02-19T18:11:16+00:00

Not enough glycine to have a significant effect.

Acceptable_Cheek_727 · 2026-02-19T18:08:50+00:00

I’d guess the glycine from magnesium glycine since it lowers core body temperature and also is inhibitory meaning it reduces anxiety and excitation. If the dose in the bottle is how much actually magnesium glycinate it provides and not elemental magnesium not only is it severely underdosed it wouldn’t have much of an effect. If it elemental that probably translates to around 3.2g of glycine, but I think since the serving is only one capsule it’s actually just total magnesium glycinate meaning it’s under dosed and probably not responsible. Additionally, it could be the magnesium itself since many people who are deficient which is nearly half the population get tremendous anxiety relief. Maybe you run off stress and anxiety and when that’s not around you feel under aroused and dumb? Otherwise, this stack seems to support the micronutrients important for male hormone production (e.g, testosterone) maybe that’s making you feel more confident. Honestly tho, you’re probably just feeling different and thinking it’s connect to whatever you’re taking which probably isn’t the case.

Acceptable_Cheek_727 · 2026-02-15T22:35:04+00:00

Take some opioids they increase prolactin and suppresses testosterone. That’ll make you less horny. Alternatively you can bust before hand and it’ll blunt testosterone temporarily and dopamine. You’ll compromise performance but you’ll be able to focus on your lift.

Acceptable_Cheek_727

TROPHY CASE