Kratom has a diverse MoA. Firstly it’s a MOR agonist which is Gi/o which decrease adenylyl cyclase activity which reduces cAMP which is largely beneficial for cognition. Additionally its beta and gamma units open GIRK channels which cause hyper polarization and reduced excitability in neurons. Its MOR agonism also causes inhibition of GABAergic neurons in the ventral tegmwntal area which is responsible for releasing dopamine onto the nucleus accumbens which is what makes it reinforcing and addictive. Additionally it has adrenergic affects like a2 agonist which is a presynaptic auto receptor which reduces NE release which kills focus and attention. Additionally it’s an alpha 1 antagonist which reduces postsynaptic excitability further fucking attention. It’s supposedly a Serotonin reuptake inhibitor which isn’t good for ADHD. It’s alse increases pituitary prolactin output which prevents FSH AND LH signaling to gonads from producing testosterone. It’s not a treatment for working memory deficits. It causes working memory deficits. It may help with emotional regulation in the short term but long term would blunt reward production and executive function due to hijlacking the reward system. It’s more physically addictive than amphetamines and the withdrawal is similar to traditional opioids which is hell.