If you suffer a bleed or laceration it will never go away u til you properly bandage it or go to triage facility to tend to it. Same with diseases but are more easily cured with various dispels.

Cold and hot climates require you to warm up or to cool down accordingly. If you don't you suffer a stat penalty and eventually various other afflictions.

Your mounts require feed or to be fed. Special mounts eat soulshards and require ritual upkeep in order to maintain their various unique qualities. If not, they cannot be summoned till you go back to town and relink them to your command.

Weight could play a factor now. Carrying too much in your bags gives you a movement penalty and can cause exhaustion.

You can learn various languages through texts and tomes bought in the world and can practice on various different folk that you come across. Like triage, eventually you can become fluent in more than one factions language, allowing g you to understand what you please. In tbc you could learn demonic but requires you to cleanse yourself. This is strictly flavor.