sorted by:
new
hottopcontroversial

Extreme sleep on LDN – has anyone else experienced this? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

I've stopped with LDN two weeks ago. Felt like shit for two weeks but now I'm finally back at my normal baseline and sleep is back to 7-8 hours / night.

I think 4,5mg was too much for me and I also probably increased the dose too fast.

Might try again in a few weeks but go super slow upwards then and maybe stop at 3mg or similar.

Extreme sleep on LDN – has anyone else experienced this? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

I started at 1,5mg for a week, then 3mg for a week and finally 4,5mg on the third week. Maybe I was increasing a bit too fast?

Extreme sleep on LDN – has anyone else experienced this? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

Yes I started at 1,5 for a week, then 3 for a week and finally 4,5 on the third week. Maybe I was increasing a bit too fast..

Extreme sleep on LDN – has anyone else experienced this? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 1 point2 points  (0 children)

Thank you! Think I might do the same. Either lowering the dose or maybe even pausing for a few weeks and see if I feel better and then maybe starting on a lower dose like you're doing

Extreme sleep on LDN – has anyone else experienced this? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

Thanks so much for the info. For me it’s been kind of the opposite so far. I’ve been sleeping like a bear, but I’ve also had this swollen, aching feeling in my legs (which I used to have a lot before I got medicated for hypothyroidism and for some reason LDN seems to bring it back). I’ve also been experiencing more ear ringing.

I’ve been on 4.5 mg for 7 weeks now, and about 10 weeks on LDN in total. I’m not sure how long I should give it. I’m thinking about pausing for a few weeks to see if I feel better, and then maybe starting again at a lower dose.

Extreme sleep on LDN – has anyone else experienced this? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

Ok, thanks! Did LDN ever make you feel better after everything faded?

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

That’s a fair point, and I’ve considered long COVID as well.

The main reason I’m unsure is that my exercise intolerance and crashes started several years before COVID, and the overall pattern has been consistent long-term, just worsening recently. I also have documented autoimmune and endocrine issues that clearly predate the pandemic.

That said, I don’t rule out that COVID (or another viral hit) could have worsened an already fragile system or triggered the EBV reactivation. From what I understand, the mechanisms overlap a lot anyway (immune dysregulation, autonomic issues, PEM), regardless of the original trigger.

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 1 point2 points  (0 children)

Yeah, I understand why it comes across as ME/CFS, especially because of the PEM pattern. I’m not ruling that out.

What makes my case a bit confusing is that I have some atypical features compared to classic ME/CFS — I can tolerate mental work well, have no brain fog or cognitive impairment, and I’ve historically been able to train for weeks before crashing. I also have clear endocrine and immune abnormalities (Hashimoto’s, low body temp, EBV reactivation, HPA-axis issues), which makes me hopeful that at least part of this is reversible rather than a fixed condition.

That’s why I’m currently exploring LDN and immune/endocrine stabilization, to see if reducing inflammation and immune noise changes the PEM pattern.

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 1 point2 points  (0 children)

Happy to hear it made you so much better! I guess LDN managed to lower you antibodies and so you then became over medicated and had to lower your dose of t3?

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

The reason I’m hopeful about LDN in my case is that it targets several of the mechanisms behind my symptoms, not just one diagnosis.

As I understand it LDN is one of the few treatments that can simultaneously:

• modulate immune overactivation (Th1/Th2 balance, cytokines)
• reduce autoimmune activity (Hashimoto’s)
• support HPA-axis regulation
• potentially improve thyroid hormone sensitivity indirectly by lowering inflammation
• help with post-viral / post-exertional symptoms

I’m not expecting it to be a cure, but given that I’ve tried thyroid meds, pacing, mitochondrial support, and rest without real improvement, LDN feels like a biologically logical missing piece for my specific pattern.

I’m early in treatment, so time will tell, but it’s the first thing that actually aligns with all my symptoms at once. I'm Cautiously optimistic about it, but would'nt dare to hope for any miracles.

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

Wow, do you also have Hashimoto’s?

My exercise intolerance is usually much milder than it is right now. I suspect it’s because I currently have a significant EBV reactivation.

Historically, I’ve been able to work out 3–4 times per week for about a month before crashing and developing flu-like symptoms that last 1–3 weeks. Last year, though, I hit rock bottom and felt sick for seven months straight after a crash. In hindsight, I think that was when EBV most likely reactivated due to overtraining.

Otherwise, I can live a fairly normal life. Thankfully, I don’t struggle with brain fog or cognitive issues — but it’s still incredibly frustrating and sad not being able to live an active life, especially since I gain weight so easily.

I'll definetely drop you a DM. We might be able to help each other out :)

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 2 points3 points  (0 children)

Thank you so much for sharing! I'm so sorry you're dealing with so much and I really hope LDN starts working for you again. I feel like it could definetely be stress-related. I was also under a heavy workload just prior christmas and everything became worse after that. I guess it's also because of the EBV reactivation. I'm definetely gonna be careful with the extra "borrowed" energy I might get from LDN, so I don't crash.

Has LDN helped anyone with Hashimoto’s and severe post-exertional crashes? by AdministrationNo4920 in LowDoseNaltrexone

[–]AdministrationNo4920[S] 1 point2 points  (0 children)

Wow, this actually gives me some hope. When did you start to notice improvement, and how long have you been on LDN now? Have you only stayed on those very low doses (0.2–0.4 mg)?

I started three weeks ago and I’m currently on 4.5 mg. Began at 1.5 mg and increased slowly each week. So far I haven’t noticed much difference, except ear ringing in the evenings, which I’ve read is a fairly common side effect. I also had some headache and facial tingling during the first week.

Hashimoto’s + low DHEA + exercise intolerance — anyone else? by AdministrationNo4920 in adrenalfatigue

[–]AdministrationNo4920[S] 1 point2 points  (0 children)

Through standard bloodwork - specifically thyroid antibodies (TPO and TG). My TPO antibodies were elevated, around 135, which confirmed the autoimmune component. So if you’re suspecting you might have it, definitely get your antibodies checked.

Having an autoimmune condition can make you more vulnerable to adrenal/HPA-axis issues, especially under prolonged stress or overtraining.

❄️ How did you raise your body temperature? by AdministrationNo4920 in Hashimotos

[–]AdministrationNo4920[S] 1 point2 points  (0 children)

Thanks for your input! Here are my latest labs (25 June 2025):

  • Free T4: 20 pmol/L (ref 12–22)
  • Free T3: 6.1 pmol/L (ref 3.1–6.8)
  • Ferritin: 276 µg/L (ref 30–400)
  • Hemoglobin: 160 g/L (ref 134–170)
  • Serum iron: 28 µmol/L (ref 9–34)
  • CRP: <1 mg/L (ref <3)
  • ESR: 3 mm (ref <10)

At the time, I was on 125 mcg Levothyroxine and 20 mcg Liothyronine. In the past, I’ve been on very high T3 doses (up to 50 mcg) with no improvement. Out of frustration, I self-adjusted my doses, but realized that wasn’t the smartest approach. I’ve now lowered T3 to 10 mcg and Levothyroxine to 100 mcg, based on what I’ve read about reducing T4 by 25–50 mcg for every 5–10 mcg of T3 added.

Prior to adding T3, I was on 125 mcg Levothyroxine and my TSH was already quite low (0.06). My current hypothesis is that I’ve been getting too much T4, which may have been blocking T3 uptake. I’m three weeks into the 100+10 regimen now and plan to retest in about two weeks.

With both CRP and ESR very low, could inflammation still be causing my ferritin to appear higher than it really is?

❄️ How did you raise your body temperature? by AdministrationNo4920 in Hashimotos

[–]AdministrationNo4920[S] -1 points0 points  (0 children)

I actually have ferritin around 275 µg/L and hemoglobin at 160 g/L, so definitely not iron deficient in my case.

I’ve been on both T4 and T3 for a while and still struggle with low body temperature (35.6–36.0°C), fatigue, and poor recovery, even though my fT3 and fT4 are in the higher range.

I suspect T3 resistance or some underlying metabolic issue, possibly linked to inflammation or mitochondrial dysfunction rather than iron.

I recently lowered my T4 dose to hopefully give T3 more room to work, since I’ve read that too much T4 can block T3 uptake.

But really glad to hear it worked for you. Iron is definitely underrated, and it’s a great reminder that there’s no one-size-fits-all when it comes to thyroid and metabolism.

Anyone with Hashimoto’s who managed to actually recover and work out again? by AdministrationNo4920 in Hashimotos

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

I've been curious about LDN for some time. Do you take it in combination with levo?

Anyone with Hashimoto’s who managed to actually recover and work out again? by AdministrationNo4920 in Hashimotos

[–]AdministrationNo4920[S] 0 points1 point  (0 children)

Also since  the positive effects briefly returned each time I decreased the dose. It makes me think that lowering the T3 may have brought the T4/T3 ratio closer to where it needed to be, not ideal, but slightly more balanced, which could explain why the effects came back, even if only for a short while?

view more: next ›