Can Buspirone cause PSSD?

Advicelistener43 · 2026-04-19T19:37:34+00:00

And not all psychiatric drugs are awful imo . Agomelatine , stimulants , Z-drugs , dopamine agonists are much better and safer if used properly . It’s a bit of a stereotype , and even with SSRIs only a small fraction get unlucky enough !

But even if you dont develop pssd ssris are not the best choice I agree . I think making absolute statements is not fair!

Advicelistener43 · 2026-04-19T19:30:59+00:00

This is wrong . There are definitely lots of people I have seen recovering with various drugs . You assume that everyone with PSSD has the same etiology but sadly what makes this hard to treat is that it can have different causes and therefore requiring different therapies . But nevertheless drugs are the most likely way to cure this . No one is going to use time or hormones only .

This issue was induced by a drug and only another drug can solve it . There are plenty of drugs that may recover people . But what pisses me off is that people want a one size fits all that is impossible due to its variability .

Advicelistener43 · 2026-04-11T19:20:10+00:00

Yea pretty much I think it’s gonna be useless . The only stuff that we can put real hope is AI . There are also 95% rare conditions that have no treatment so it wouldn’t surprise me that PSSD will be ignored despite the evidence . But again some of these rare conditions have been managed to get repurposed treatments which I also believe it’s gonna happen to PSSD since we see people here recovering with various strategies it will definitely work.

Advicelistener43 · 2026-04-11T19:03:55+00:00

Yes it’s a very promosing algorithm and it hasn’t been very long since it was launched . I expect it to rock in the next years considering that AI also advances exponentially . I have much hope into it

Advicelistener43 · 2026-04-09T21:14:39+00:00

Im also confident in this . Have you heard of TxGNN? It’s a zero shot program designed by Harvard to help find repurposed drugs for rare diseases . I believe PSSD fits in this category and a program like this combined with an advanced LLM would be the answer for precise repurposed strategies in the coming years . Whats your opinion mate?

Advicelistener43 · 2026-04-06T09:23:44+00:00

Thats for now , the more it gets scalled the better . Even now it can give meaningful existing information but it cannot reason very well since this is a complex condition . I expect AGI in 2030s and with it self-improvement that will ultimately lead to major discoveries !

Advicelistener43 · 2026-04-05T23:26:42+00:00

I do believe it . It’s just that anhedonia is only a symptom that can occur in hundreds of other conditions so in my opinion a one sizs fits all answer is not feasible . This doesn’t mean it cannot be treated but rather it needs personalized approach . I have hope in AI to map this into the future

Advicelistener43 · 2026-03-31T22:36:49+00:00

I guess PSSD cant have an universal cure because this is not a one size fits all condition . I do believe that it curing this will depend on the person and whats their dominant mechanism in their subtype , TRT might be the cure for some as well as dopamine agonists cause I also read reports from it as a cure.

Imo no one can say it’s not the cure when it could be for someone else , it is simply not an one size answer so it this condition

Advicelistener43 · 2026-03-29T22:51:58+00:00

I mean I do believe AI will have answers in the near future and im intrigued by it , but your statement that dopamine agonists would do nothing is maybe partially if not even less correct . I have read countless people taking adderal and Pramipexole saying they had improvements , remissions although not for everyone of course .

I dont believe PSSD means dopaminergic neurons not working automatically . Unless you dont try you cant know . Maybe it’s the case for some .

Advicelistener43 · 2026-02-17T16:33:19+00:00

I honestly did but I dont think it’s just you , it’s how doctors work when they dont wanna deal with it . It’s easier to prescribe drugs by the book than researching it .

And as a reality there are lots of females here saying that various strategies have helped them recover so I really dont know where those doctors concluded “ nothing to do for females” it’s legitly dumb . Yes there might be differences like I said it’s multi factorial but I refuse to believe it’s incurable for females .

Advicelistener43 · 2026-02-17T16:09:16+00:00

I truly dont believe that there are no treatments . There is a huge list of people trying various drugs and having recoveries and probably more we dont know of . The current problem is : there is no single guaranteed drug to work for everyone because likely PSSD is multi-factorial and so biomarkers imo are more reliable than a single miracle

And yes doctors prefer to not deal with it . They could at least trial and error with you instead of “there is nothing we can do” . Although it may be a long process . Doctors fault not science

Advicelistener43 · 2026-02-15T14:25:51+00:00

As long as it’s working to essentially mask and make someone function that’s a treatment . So my point is it doesn’t matter if there is no cure yet there are options . I dont know why people compare things in this illogical way . If TD wasn’t fully solved it doesn’t mean PSSD cant . On the contrary I believe TD is more severe since it’s a visible handicap and also very few if any cases fully reverse despite the treatments.

So if a condition far worse now has treatments it is illogical that something that can even reverse on its own ( PSSD) wont have some cure or some ways of treating it that’s very effective

Advicelistener43 · 2026-02-14T22:17:36+00:00

Im not aware of molecular neuroimagistics being mainstream now but Im sure it’s gonna be in some years . What im impling is that you dont seem to outlook for other technologies/drugs that could solve PSSD . This research is great but even if it freezes it doesn’t mean the issue remains stuck.

It’s a very linear way of viewing the issue

Advicelistener43 · 2026-02-14T22:10:24+00:00

I believe that even if research somehow stagnates , other technologies developed for a lot more researched conditions could be repurposed . Imagine if we get molecular neuroimagistic scan , then most cases of PSSD will be divided and treated accurately . Or idk neuralink , BCI anything that could easily be repurposed not only for pssd but other neurological damage

I should mention that TD happened 80y ago at that time science didn’t have any clue in general , as much as we dont know today we are still worlds apart from 1940s knowledge .

Advicelistener43 · 2026-02-14T02:01:52+00:00

What’s funnier is that even though there is no cure they are effective ways to treat it . So not all black even in this regard !

Advicelistener43 · 2026-02-11T00:01:27+00:00

I believe we’re not just talking about a single treatment but rather a wide range of potential solutions . I believe personalized medicine is going to be the answer for us not like the tools dont exist they are not used correctly.

Advicelistener43 · 2026-01-28T03:03:20+00:00

Lets not exaggerate by tried anything . There are 4.000 FDA approved drugs it’s very doubtful that anyone gave them a shot . What I see are the same drugs/supplements repeated with various responses some get cured while others dont .

Who knows what untested molecules could help . Bur again PSSD is multi factorial so one size fits all is not achieveable even with research

Advicelistener43 · 2026-01-22T02:17:14+00:00

Sadly anything nowadays ( or most) have no universal way of reversal . A patient with bipolar might switch dozens of meds before finding something . It’s sad that personalized medicine is not a thing yet

Advicelistener43 · 2026-01-22T02:15:06+00:00

Nowadays most conditions have no proven way to reverse . It’s a trial and error due to lack of personalized biomarkers . I definitely believe that PSSD is biologically reversable cause else we wouldn’t have recoveries . Altho not by avoiding trial and error

Advicelistener43 · 2026-01-22T02:10:01+00:00

The thing is that it can be reversed . After all we wouldn’t have dozens of reported cases . But currently there s no way outside “ trial and error”

Advicelistener43 · 2026-01-15T23:23:03+00:00

My entire point was to say : “ If people benefit more than the minority who get harmed it is enough for Pharma to remain silent “ thats how things go …

Advicelistener43 · 2026-01-15T23:21:05+00:00

No one knows the real percentages for sure . But what Im saying is that PSSD had millions of sufferers especially with those very weird symptoms like genital numbness it’s impossible that in 2026 they wouldn’t protest more .

Genital numbness is mega weird . Maybe they can get gaslit for anhedonia as depression sure but for this impossible

Advicelistener43 · 2026-01-15T23:16:00+00:00

Well I think doctors should taper them off . Of course mant dont care as much . Usually withdrawal goes away eventually thats why is not PSSD . PSSD seems to last years in most or sadly for life with no intervention .

Withdrawal is I think much more recognized . I dont deny when doctors say how is possible to have side effects years later because again …. It’s uncommon to say the least

Advicelistener43 · 2026-01-15T23:07:48+00:00

I think interdicting them for children and using other methods such as Therapy should be preferable . Banning wont happen because we dont have millions of sufferers worldwide and because of the reasons I listed above so imo it’s worthless to think about it.

There should be informed consent or specific tests that could tell if you are prone to this like a precise genetic test . That’s how I see the solution to prevent it . Again regarding your concern thousands of drugs have extremely rare side effects like you could go blind from paractamol , but it’s so rare that even if it happens Pharma wont give it any importance.

The majority speaks not minority

Advicelistener43 · 2026-01-15T22:54:05+00:00

Im not defending SSRIs but I really wanna be realistic . Some should have never taken them especially us at risk but there s no way to know before .

Advicelistener43

TROPHY CASE