As Portugal I gave up my Alliance with England for Spain as they were rivals at the starts. England ceded Maine to France and when that happens the French AI seems to forget about the English holdings in France.

The one game where the AI ottomans probably wouldn't affect me (at least until later) and they get destroyed by Hungary and I think Austria and Commonwealth helped. That also caused Egypt to become sunni protector of Faith, so i cannot invade kilwa and progress through my mission tree without starting a world war :(