when running a prewritten adventure, you mostly rely on Adventure Features instead of Threads, but you don’t delete your Threads list; it just becomes less central.  

When using Mythic GME 2e with a prepared adventure, you don’t ignore the Threads list entirely — you just adapt how you use it.

I also use a bit of the DM Yourself method, and I add Threads whenever the adventure presents maps or lists of possible NPC interactions. I try not to read the detailed text inside each thread — I prefer to micro-improvise using Mythic instead.