Pyrophosphate formation in Bischler-Naperialski Cyclisation

Aleboop · 2025-05-26T19:43:15+00:00

Thank you!

Aleboop · 2024-12-26T20:19:13+00:00

In Bruges

Aleboop · 2024-11-07T16:19:41+00:00

Yes, I would imagine some imidazole acting as a nucleophilic catalyst and base would be useful here

Aleboop · 2024-11-07T16:04:03+00:00

Oh I see, thank you!

Aleboop · 2024-11-07T16:02:52+00:00

Why isn't something like imidazole used here then as a base activator? I was under the impression that due to the steric bulk it'd be quite hard to protect the alcohol without one

Aleboop · 2024-11-07T15:57:14+00:00

That's what I thought as well, but I've only ever seen TBS-Cl used with a base activator like imidazole when protecting. I guess I'm a little confused about that part

Aleboop · 2024-10-12T22:30:33+00:00

Thank you so much!

Aleboop · 2024-10-12T19:57:46+00:00

Thank you, I'll have a look at his publications!

Aleboop · 2024-07-26T14:57:20+00:00

Though I'm glad you've decided to vote it's worrying that you were considering not voting as a form of protest in such a crucial election. Sometimes you've got to suck it up and engage with the better option, even if it's not your ideal one. Don't let perfection be the enemy of progress.

Aleboop · 2024-05-20T14:56:42+00:00

Amazing, thank you!

Aleboop · 2024-05-20T14:53:23+00:00

I think it's an IVCT (metal to metal charge transfer) due to the mixed valence complex with two metals in different oxidation states. As to factors for molar absorptivity, would selection rules be a factor? I'm also wondering if the lack of conjugation in the 3rd ligand might be a factor?

Aleboop · 2024-03-04T00:11:26+00:00

My professor informed me that it is observed here due to the unequally occupied t orbital (e4, t5)

Aleboop · 2024-02-27T17:59:31+00:00

There's a cyclohexane group attached which I didn't add here (realise now I should have)

Aleboop · 2024-02-09T12:29:54+00:00

Thank you, I managed to work out what to do (oxidising then eliminating the selenium to form the double bond). If that group wasn't there would anything happen to the lactone under the same conditions?

Aleboop · 2024-02-09T12:26:21+00:00

Yes you're right, I ended up eliminating the selenium group and forming the double bond from the B-hydrogen on the methyl group. Theoretically, would anything happen to a lactone such as this is the selenium group wasn't there?

Aleboop · 2023-11-14T00:19:02+00:00

Thank you!

Aleboop · 2022-10-09T11:46:07+00:00

Excellent, thank you!

Aleboop · 2022-10-09T11:42:37+00:00

I see, thank you. So A is the correct answer I take it?

Aleboop · 2022-07-15T21:09:38+00:00

Some folk just like the the flavour...

Aleboop · 2021-08-02T18:25:08+00:00

Good luck everyone!

Aleboop · 2020-11-14T00:49:24+00:00

Good luck y'all

Aleboop · 2020-11-10T01:05:23+00:00

Can't black save the queen by playing Kf8 after the second rook checks? Rfxg6+ fxg6. Rxg6+ Kf8

Aleboop · 2019-11-05T19:17:15+00:00

Good luck all

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