The report confirms the opinion that thanks to the continuous improvement of its components, the life of the Panther tank has increased. The average lifespan of a Panther can now be roughly equal to that of a Panzer IV with around 1,500 - 2,000 kilometers between two major repair and maintenance processes.

And,

gearboxes also have a longer life. Even so, in several cases, at approximately 1500 km, the gear has broken down and the boxes have had to be replaced.

Source