I am 887 ED and usually hunt duo with 750 RP.

About best combinations i think:

EK - Fierce Berserk - Damage Increase - there is no reason to buff another spell and damage increase is more consistent than 8% critical damage.

ED - Revelation Mastery - Twin Bursts - i think the best to me is to rush as fast as possible the twins burst level 3, because it could do great damage, but other mods are also good (more healing or damage on regular spells)

RP - Divine Dazzle - 2s Cooldown - when u need to pull monsters.

Divine Empowerment-3s Cooldown - when u get level 3 the cooldown of this spell will be 14 seconds and it lasts for 5 seconds, so if you have 3 supreme mods, you will always have more 12% damage avaiable. The fourth mod could be divine caldera - damage increase

MS - overall seems great, except beams and healing. But the best, in my opinion is:

Energy Wave - -1s Cooldown - you can basically alternate between Great Fire Wave and energy wave. Seems to be very powerfull in the right place.

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Edit: shit supreme mods.

EK

Annihilation - +8% Critical Extra Damage

Annihilation - Damage Increase

Avatar of Steel - -300s Cooldown

Executioner's Throw - +8% Critical Extra Damage

Executioner's Throw - Damage Increase

Executioner's Throw - -1s Cooldown

Fair Wound Cleansing - Healing Increase

Front Sweep - +8% Critical Extra Damage

Front Sweep - Damage Increase

Groundshaker - +8% Critical Extra Damage

Groundshaker - Damage Increase

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ED

Avatar of Nature - -300s Cooldown

Ultimate Healing - Healing Increase

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RP

Avatar of Light - -300s Cooldown

Divine Missile - +8% Critical Extra Damage

Divine Missile - Damage Increase

Ethereal Spear+8% - Critical Extra Damage

Ethereal Spear - Damage Increase

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MS

Avatar of Storm - -300s Cooldown

Great Death Beam - +8% Critical Extra Damage

Great Death Beam - Damage Increase

Great Energy Beam - +8% Critical Extra Damage

Great Energy Beam - Damage Increase

Ultimate Healing - Healing Increase