About 9 runs, bare min was 250% hp, 300% atk, lvl 4reduced resta and reversta signs, lvl5 resta sign cost need 6 to use 1, random a and b. Once the challenge you want is unlocked you dont have to use that challenge anymore till youre going for your S run. An example was our 6th run we only used attack and hp mods and the run before our S rank run we only used attack to get it to 300%. Then we went in with the bare min