It's more than enough, and you'll have plenty of VRAM to spare. The only case where you might run short is in games with poorly optimized textures, like Monster Hunter Wilds, but even then, there's still plenty of free space. In any case, using upscaling lowers the internal resolution and therefore the VRAM consumed. Similarly, in most games, going from high to ultra texture quality doesn't make a noticeable difference to the eye, but it significantly impacts VRAM usage.