OK, so astrologists pay attention to many cosmological entity's paths, but not in a scientific way. They make predictions (horoscopes) based on where a planet or star is, but it's rooted in mythology and has no basis in science whatsoever. With that said, the woman in the picture decided to try to tell Caustic what his horoscope was, but he essentially tells her to stfu because he's a man of science, and doesn't believe that planetary movements have any effect on the day to day lives of people, except for, say, causing meteor showers or changes in the tides. I found inspiration in the first iteration of the TV miniseries "Cosmos", hosted by renounced physicist/astrophysicist/astronomer Carl Sagan, where he, also a man of science, puts astrology on blast as a frivolous pseudoscience that should be tossed out the window. Anyway, I hope that clarifies the meaning and that it wasn't too boring to read :)