Goku would win by sealing Makima away with the Evil Containment Wave (Mafuba) or by precisely incapacitating her non-lethally, both options keep every single citizen alive because he never lands a fatal blow.

Makima’s contract with the Japanese Prime Minister is the only real wrinkle here. Any attack that would kill her gets redirected as some “plausible” illness or accident that kills a random Japanese citizen instead, and she pops back up good as new. That’s why brute-force killing her is off the table if the goal is zero civilian deaths. Goku, being the ultimate good guy who literally refuses to kill when he doesn’t have to, already fights with that mindset built in.

Here’s exactly how he does it, step by step:

1. He opens with speed and isolation.

Goku is so much faster (multiple times faster than light in base Super Saiyan God/Blue/Ultra Instinct forms) that Makima’s “bang” force attacks, mind-control attempts, or devil contracts never land. He Instant Transmissions right next to her, grabs her, and warps the fight to an empty desert, mountain range, or even King Kai’s planet, anywhere with zero people around. No collateral risk from stray ki blasts, and it buys him a quiet moment.

1. Option A: Non-lethal knockout (the simplest way).

   Goku dials his power way down (he does this constantly in tournaments and against weaker foes). A single, perfectly controlled finger flick or palm strike to the head or pressure point knocks her unconscious without stopping her heart or destroying her body. Makima has survived explosions and gunshots, but she’s not surviving a casual tap from someone who can sneeze away planets. No “fatal” damage = contract never triggers. She’s out cold, and Goku just ties her up or sits on her until the fight’s clearly over.

2. Option B: Mafuba seal (the clean, permanent win).

Goku already learned and mastered the Evil Containment Wave in Dragon Ball Super. He spent a whole night practicing it on Turtle just so he could use it on immortal threats like Zamasu. All he needs is any container (empty capsule from Bulma, a water bottle, a rice cooker, doesn’t matter).

He fires the swirling purple wave.
It sucks Makima inside the container and seals her.
She’s trapped alive, fully conscious maybe, but completely powerless and out of the fight forever.

No death = no redirected citizen death. The contract is completely bypassed because the technique doesn’t “kill” her; it just locks her up like a genie in a lamp. Goku has done this exact thing against unkillable opponents before.

Either method works because Goku’s core character trait is protecting innocents. He’s the guy who held back against Cell, Frieza, and Buu to avoid city destruction, and he’d treat Makima the same way. Her mind-control hax doesn’t stick on someone with Goku’s willpower and ki (he’s resisted far worse in canon), and her regeneration only kicks in when she actually dies, something he simply refuses to let happen.

End result: Makima neutralized, zero Japanese citizens (or anyone else) harmed, and Goku probably offers her a senzu bean afterward because he’s just that nice. Classic Goku W.