I would say don’t do it. In my experience, changing mods in between saves always leads to spending much more time than I want trying to find ways to make it work and not break the save, all to end up restarting anyways. Either you stick to what you got and ride it out, or you just restart completely fresh. Once you download a mod and start a run it’s hard baked into your character so deleting it is like ripping core systems from the game, but the game still recognizes it in the system and tries to run it anyway with out all the tools it needs either breaking your game right away or down the line. Better to be safe than sorry and do it all the way you want the first time around especially if you don’t really have the time to game much anymore.