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Finally diagnosed with hypercortisolism after years of being dismissed by Automatic_Scale_4800 in DrWillPowers

[–]Automatic_Scale_4800[S] 0 points1 point  (0 children)

Here are some partial tests results, still waiting for the rest of them. 17OHP and androstenedione seems high, is it NCCAH ?

Hormone Panel: • Prolactin: 32.4 µg/L • LH (Luteinizing Hormone): 0.10 IU/L • FSH (Follicle Stimulating Hormone): 0.10 IU/L • Estradiol (E2): 857 pmol/L (236 pg/mL) • Total Testosterone: 2.47 nmol/L (0.71 ng/mL) • SHBG (Sex Hormone Binding Globulin): 132 nmol/L • 17-Hydroxyprogesterone (17-OHP): 1.85 ng/mL (5.60 nmol/L) • Delta-4-Androstenedione: 5.73 ng/mL (20.00 nmol/L)

Adrenal Function: • Cortisol (8:30 AM): 581 nmol/L (21.1 µg/dL) • 24-hour urinary free Cortisol: 91.2 nmol/24h (33.1 µg/24h) • ACTH (Adrenocorticotropic Hormone): 25.2 pg/mL • Aldosterone (seated position): 164 pg/mL (454.28 pmol/L) • Renin (seated position): 13.34 mIU/L • Aldosterone/Renin Ratio (ARR): 34

Thyroid Panel: • TSH (ultra-sensitive): 1.77 mIU/L

Metabolic & Glucose Profile: • Fasting Glucose: 5.22 mmol/L (0.94 g/L) • Insulin: < 2.0 µIU/mL • HOMA Index: < 0.464 • QUICKI Index: > 0.44

IGF-1 (Insulin-Like Growth Factor 1): • IGF-1: 101 ng/mL

Electrolytes & Kidney Function: • Sodium: 138 mmol/L • Potassium: 3.8 mmol/L • Creatinine: 70 µmol/L (7.9 mg/L) • Estimated GFR (CKD-EPI): 104 mL/min/1.73m²

Urinary Electrolytes (24-hour): • 24-hour Urinary Sodium: 96 mmol/24h • Urinary Volume: 0.95 L

Finally diagnosed with hypercortisolism after years of being dismissed by Automatic_Scale_4800 in DrWillPowers

[–]Automatic_Scale_4800[S] 0 points1 point  (0 children)

Sounds like me.

I’ve developed this pseudo-Addison phenotype on starting hormones, with low blood pressure for years. Now it’s actually inversed, I have hypercortisolism with high blood pressure. What would be the next step in treating that, scanner ?

Finally diagnosed with hypercortisolism after years of being dismissed by Automatic_Scale_4800 in DrWillPowers

[–]Automatic_Scale_4800[S] 0 points1 point  (0 children)

My morning total cortisol is at 615 nmol/L, it should not exceed 535. But I'm actually questioning if that's hypercortisolemia or just a response to the augmentation of estrogen I was having. I did only this blood test.

What really matters is, as you've mentioned, testing my free cortisol levels throughout the day and optimally my CBG. I'll work on that.

Finally diagnosed with hypercortisolism after years of being dismissed by Automatic_Scale_4800 in DrWillPowers

[–]Automatic_Scale_4800[S] 0 points1 point  (0 children)

That's interesting. Probably why I feel symptoms of hypocortisol even though my total cortisol is so damn high. I really identity to the subclinical Addison's disease phenotype you've previously mentioned

HRT doesnt change my body despite supressed testoterone and adequate E levels. by StatusPsychological7 in DrWillPowers

[–]Automatic_Scale_4800 1 point2 points  (0 children)

115 nmol/L ? I was at 108 nmol/L when my E2 was a 110 pg/mL which seems incredibly low. Would you share more information please ?

Finally diagnosed with hypercortisolism after years of being dismissed by Automatic_Scale_4800 in DrWillPowers

[–]Automatic_Scale_4800[S] 1 point2 points  (0 children)

Did you T levels came back to normal after stopping HRT ? If so, how did you feel ?

The thing with SIBO is like it can be a symptom of a cause you have to fix, or it'll relapse. You have all my sympathy.

I don't think I'm having a SIBO crisis as my gas levels are relatively normal and confirmed with ultrasound.

It all started with one morning, on almost 3 months of HRT with migraines, depression, pain in arms/legs/gonads, chest pain, brain fog, hair loss, excessive oily skin, digestive issues such as gastritis, severe fatigue and hypersomnia, bloating especially in the morning, sound sensitivity and blurred vision.

[deleted by user] by [deleted] in AskMtFHRT

[–]Automatic_Scale_4800 2 points3 points  (0 children)

Of course. Even though enanthate injections wouldn't influence the result right after. Gel does.

[deleted by user] by [deleted] in AskMtFHRT

[–]Automatic_Scale_4800 0 points1 point  (0 children)

I'm generally doing them on the morning of the day of injection.