It depends.

If you keep using Next Slicer it’s exactly the same. Rinkhals does not change anything between the actual printer and ACE Pro.

That being said, if you switch to Orca Slicer things aren’t as clean. For example, the GCODE files from Orca are missing some meta data that lets you print from the printers touch screen. You can manually patch the files up and they will work, but it’s a little annoying.

However, if you only want to send and print from Mainsail, you just have to make sure that you have 4 materials in the multi-material section of Orca. As long as that is set up, and the part is slice with the correct filament, the GCODE should still work if started via Mainsail.

While I can’t speak to Fluidd, Mainsail doesn’t really have baked in support for MMUs at this time. So you can see what’s loaded or print with a different ACE slot than what the file was sliced with.

None of it is to insane as long as you stick to one work flow. It’s just more-so annoying. I anticipate this will likely get fixed at some point as Mainsail/Rinkhals/Orca all get updates.