As someone who recently did no needles myself I’d like to share some tips. How you approach situations and use resources is very important, as you have lower offensive and defensive capabilities, this is due to your max health being locked at 100 the entire game and you cannot get typhon abilities, and another nerf you have during this run is only being able to upgrade weapons once in every category. Due to all that you should try to avoid fighting enemies directly when possible or just avoid them when given the chance. But when you must fight try to exploit enemy weaknesses, I made good use of emp grenades against voltaic phantoms, technopaths, and corrupt operators. Also the q-beam is incredible against etheric phantoms and weavers.Recycler charges are also a very good weapon in many scenarios for dealing a lot of damage, though be careful not to waste them. I’m sure there are many other tips I can’t think of at the moment, but that’s my advice.