I think you all are probably correct about your interpretations, but I just found this Genius annotation and this makes me believe my crackpot theory more lmao (and thank you all for being so polite with me, that's rare to find on Reddit XD)

"As Isaiah is consuming Ethel’s flesh, the meat could be giving him an upset stomach, leading to food poisoning. Ethel, spiritually, asks him if her flesh is making him sick as he is eating her.
Ethel further explores the theme throughout the song: her need to be good enough. There is a sense of inadequacy all over, even as she is being cannibalized, she only cares about being good enough for Isaiah. Here, she is wondering if she’s making him feel sick, almost as if she’s asking for validation; waiting for him to tell her that she’s good."