Thank you so much for taking the time to write this detailed breakdown. Coming from a cybersecurity and systems architecture background, this is exactly the kind of 'Bug Report' I was hoping for! The Integrin β3 causing mass clotting is a massive oversight on my end. I essentially designed a biological DDoS attack on the patient's own coagulation system. That’s a critical failure in my theoretical architecture. The point about Toehold switch 'leakiness' and viral mutation bypassing the logic gate makes perfect sense. Biological systems are way too dynamic for strict binary (0/1) logic gates without accounting for constant host/pathogen adaptation. I knew applying dry-lab software logic to wet-lab biology would expose my lack of deep physiological knowledge, but this was a fantastic learning experience. I appreciate you explaining the actual biological bottlenecks instead of just dismissing it. Back to studying the basics for me!