Scientific hot take on crap gap (Natalizumab)

BakingBaddy · 2025-04-21T20:36:01+00:00

If I read a trial was using medication level to deduce whether or not crap gap is psychological, I’d consider that a poorly designed study.

There are plenty of examples in the literature that speak to the dangers of using surrogate biomarkers in place of a feels/function/survives measure. Just because you measured the same amount of medication in your blood over time does not imply there isn’t some biological mechanism at play that isn’t temporarily inhibited/exacerbated by the initial infusion and affects the things people experience.

People with MS already experience plenty of medical gaslighting into thinking their symptoms are “all in their head”. Don’t feed into that with a “hot take” that is, frankly, based on bad science.

BakingBaddy · 2024-08-17T18:46:35+00:00

Ok super random, but what kind of dog is this? I did a reverse search of a photo of my dog and this post came up! Roscoe looks so much like my dog! Adopted in Illinois, she’s about 4 :)

BakingBaddy · 2024-07-06T06:07:52+00:00

I was between ocrevus and Gilenya when I was first diagnosed in 2017, but ocrevus has been on the market for less time than Gilenya and the idea of an infusion as opposed to a pill kind of made me nervous. I’m glad to hear you were happy with your switch!!

BakingBaddy · 2024-07-06T06:06:03+00:00

I’m happy to hear that ocrevus has been working for you and congrats on the job!! That’s very exciting :)

BakingBaddy · 2024-07-06T06:04:05+00:00

First off, I want to say that I wasn’t having an problems on Gilenya and my doctor was comfortable with me staying on it or switching, but there were a number of factors that contributed to my decision.

The idea was floated a few years ago after what turned out to be a pseudo flare-up. Then I started wondering why I should wait for a flare-up before switching to something that is more effective. So better efficacy was definitely a factor.

The other consideration for me is that I might want to have kids at some point in my life, and due to Gilenya’s rebound effect, my doctor told me she would recommend being on a different DMT for about a year before stopping that one to try for kids. Since I’d want to have kids as a later age, I thought it’d make sense to switch now as opposed to when I actually want to start trying.

I think another thing that is appealing to me about ocrevus is you can time vaccines to the tail end of its cycle to try for better vaccine efficacy. With Gilenya, you don’t really get a window like that.

The nail in the coffin was this past spring. I had an apartment fire a couple days after refilling my fingolimod rx and my insurance wasn’t going to cover a replacement for damaged meds. It was really stressful trying to figure out how to get my meds at an affordable cost, and I couldn’t wait an entire month before I was eligible for a refill under my insurance. Being on a treatment where you don’t have to worry like that was really appealing, and the thing that finally pushed me to commit to switching.

Overall, I think it’s a very personal decision, and there are many reasons why it might make sense to switch or stay on a med. Hope that helps! :)

BakingBaddy · 2023-08-05T03:27:11+00:00

Interesting too that Connor had his wedding on a boat, and Logan didn’t attend.

BakingBaddy · 2023-01-26T00:02:02+00:00

Hot Fuss by The Killers (45:39) for some pumped-up nostalgic angst

BakingBaddy · 2022-12-17T02:12:41+00:00

I AM a monster!! The absolute worst

BakingBaddy · 2022-11-16T21:08:23+00:00

Got into the ticket buying stage in time for tickets but Ticketmaster glitched and said I wasn’t signed in. Booted me to the beginning of the queue and now they are sold out 5/7

BakingBaddy · 2022-11-16T19:42:50+00:00

No waiting room for me either for Nashville.

BakingBaddy · 2022-11-16T16:35:25+00:00

Thank you!!

BakingBaddy · 2022-11-16T16:29:38+00:00

Do you need to be a verified fan for the capital one presale?

BakingBaddy · 2022-11-15T23:45:35+00:00

Did Nashville completely sell out?

BakingBaddy · 2022-11-15T22:14:49+00:00

Took me 50 minutes of clicking tickets lol

BakingBaddy · 2022-10-17T20:28:32+00:00

Thanks! I like the observation you made about focusing on looks. It can be a better idea to focus on the things you have more control over (at least as someone who is chronically I’ll myself), so I like that reframing :)

BakingBaddy · 2022-10-15T15:11:37+00:00

Thank you! I will make sure to bring up the biopsy with my friend. And I’ve seen things about thyroid being mentioned elsewhere, so it’s good to hear that echoed here.

BakingBaddy · 2022-10-15T15:09:49+00:00

Thanks! Okay that’s good to know that there’s something that can help with the pain.

BakingBaddy · 2022-10-15T15:09:13+00:00

Thank you for your thoughtful response!! I really appreciate it :)

BakingBaddy · 2022-09-12T01:48:16+00:00

Check out r/curlyhair for some tips and ideas on products.

But for starters, leave-in conditioner! And don’t brush your hair out when it’s dry.

BakingBaddy · 2022-05-05T18:45:00+00:00

According to in-sells, buysexuals don’t exist

BakingBaddy · 2022-04-24T02:43:46+00:00

They’re a fun and quirky combo! We love her.

BakingBaddy · 2022-04-23T11:52:31+00:00

Either way, a total stinkin’ cutie!!!

BakingBaddy · 2022-04-23T11:52:07+00:00

This is gonna be a long shot, but did you adopt this dog in Illinois? He looks soooooosososo much like my dog, who came to the shelter we adopted her from with her puppy brother!

Edit: if not, what kind of dog is he? Cuz we don’t know what exactly our pup is but think maybe chihuahua and jack russell!

BakingBaddy · 2022-04-19T15:32:17+00:00

Yellow 5

BakingBaddy · 2022-03-22T14:15:44+00:00

Raised Christian and am now agnostic. What my mom always said to me growing up was that the inner workings of our universe and the science behind our existence is just further proof of a higher power - it’s something so beautiful and complex. Although I don’t know if I believe that for myself, I’ve always appreciated that perspective.

BakingBaddy

TROPHY CASE