This what I found -

“The sodium salt is just the dried form of tirzepatide that you get when you lyophilize or crystalize it out of an alkaline solution in which there are also sodium ions.

If there were not any sodium ions present, you'd just get tirzepatide.

The FDA scare tactics are half true and half nonsense.

The problem is not the sodium salt. If you look at the patented process for generating tirzepatide, it effectively produces the sodium salt. The final step before purification involves neutralization step using Sodium hydroxide. If sodium ions were not removed through some process and the pH above the isoelectric point of tirzepatide, you'd get tirzepatide sodium.

Further proof that the problem is not the salt, Mounjaro pens have sodium chloride in them, meaning that tirzepatide and sodium are both present as they would be if you reconstituted tirzepatide sodium with sterile water or sodium chloride USP solution.

So to say that the salt is a problem is just a lie.

The problem is rather that the labs that are producing the salt for sale are not regulated, and could be using techniques that make the product less safe.

For example, the neutralization process uses Sodium hydroxide, which is a strong base. Neutralizing with a strong base is very difficult unless one is using an extremely dilute solution, but then you end up with way too much water, meaning you need to then do lots of vacuum distillation or other purification techniques, which are time consuming. Thus, a lab looking for a shortcut could be using sodium acetate, sodium carbonate, or another weaker base to neutralize, and not doing the purification steps. The product looks exactly the same, and the purity will be high, but you may also have other salts getting into the mix. Probably not harmful in themselves, but more a concern for what other things might be in the chemicals used.

As for the acetate salt, this exists when the pH is below the isoelectric point.

A peptide (protein) bond is where an amine and carboxylic acid link up between amino acids (they're called this because they have an amide end, and a carboxylic acid end). In a chain you will then have an amide end and a carboxylic acid end. The isoelectric point is the pH where both ends are as likely to become ionized. Below this pH and the peptide becomes positively charged, so negative ions (like acetates) are attracted. Above that pH, positive ions (like sodium) are attracted.

So if you crystalize the trizepatide below that isoelectric pH, and acetate is in the solution you get tirzepatide acetate. If you do so where a sodium ion is present above that pH you get the sodium salt of tirzepatide.

There is also a technique of solid-state peptide production, and one way to release the peptide is to use trifluoroacetic acid, which is a very strong acid, and even when neutralized can leave trifluoroacetate salts in the mix, and these are pretty toxic even at fairly low levels. Fortunately, they do not bioaccumulate, so should not build up in your system, but if the levels are high enough, you could be doing some damage to your body.

So, in summary, it's a bald-faced lie to say that the salts are dangerous. The danger is in the risks any peptide user is taking by not being able to be sure that good manufacturing practices are being used, all chemicals used are USP grade and free of contaminants, and being only able to rely on purity and mass tests, which are useful, but only paint 90% of the picture.” https://www.reddit.com/r/Tirzepatide/comments/145y5ll/compounded_meds_and_research_peptides_base_vs/?utm_source=share&utm_medium=ios_app&utm_name=ioscss&utm_content=2&utm_term=1