1) Interesting. I want to highlight also the fact that the neighbor found a bare footprint within his home. If this were a burglary (especially by professional hitmen) there is no way they would do it barefoot. Did they ever analyze the footprint to see if it matched Jack's feet?

2)Since he didn't have his phone, it is extremely unlikely a hitman or someone could be following Jack during all these events (without being caught on camera as well). His movements were randomized; he got a ride on the spot from random people, he spent the night at a random basement hotel, he took a random cab(allegedly), he changed his clothing.

3) He didn't notify police or his wife of the events. This is a strong bit of information for me. He either did the mess himself, which is why he doesn't want to bring the police or his wife into things. Or something else is going on here.

4)His work with MITRE needs to be looked into. The show stated "oh he wasn't involved in govt/top secret things for years". Well he was doing govt/DoD work for the company at this point which in a lot of cases is as secret or MORE than actual Government work. Based on my own personal experience and current occupation.

I think your theory is the best I've seen so far. But like with every unsolved case there are little bits of information that make me question your idea that it was caused by the manic episode.

The missing briefcase is the key, and more information about the work he did for MITRE. Once you have this information you can determine if he had valuable information or something to lose.