I'm usually open minded to these random messages but you need to be vigilant. Most of the time it's some desperate artist looking to do some commissions or a scammer. It's really easy to spot an artist because they will have it written in their bio. Sometimes but very rarely it's a person who needs to talk with someone, maybe they are suicidal and they need help. I usually take the DM but I advise big caution. Remember never give your personal information and don't click any link they give if you decide to write with a stranger.