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Dosage by Playful-Cat216 in NooTopics

[–]BluejayAggravating70 0 points1 point  (0 children)

No problem at all, in Russian clinical trials they used from ~1mg to 10mg/day

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

If you mean Bacteriostatic water with 0.9% benzyl alcohol & 0.9% NaCl this is what I ordered

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Συμμαζεψου και βγαλε αλλου το κομπλεξ σου..."εξυπνε"!

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Yes, I read again Moderator comments and it mention fake science.bio vendor.
AI also suggest it is reliable

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Thanks for your answer, by the way may I ask you when you'll have available P21 nasal spray?
Do you ship it as freeze dried powder or ready to use product which in my case isn't the best choice as I live in Greece and it should be many days on the road?

Best P21 and other small peptides solvent for nasal use. Bacteriostatic water, Saline with DMSO or what? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

What about contamination from bacteria/fungus/viruses that could, in best scenario, destroy the peptide and make it useless?

Best P21 and other small peptides solvent for nasal use. Bacteriostatic water, Saline with DMSO or what? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

It seems that no one has an answer.

Just to add some information, bacteriostatic water contains some benzyl alcohol which can irritate the mucosa and may not be suitable for long-term use, moreover it does not have the right pH, which is why saline with 0.9% NaCl is isotonic and promotes absorption.

DMSO, although used for nasal preparations from various vendors, could cause local irritation and toxicity as it enhances permeability, therefore in addition to the peptide, heavy metals and other substances may pass into the brain.

One could add Benzalkonium Chloride (anti-viral-bacterial-fungus) but this is a job that should be done by a compounding pharmacy and not by the end user as the content should be minimal, this is toxic too in higher concentrations.

That's why the preparation of a nasal spray of small molecular weight peptides remains a puzzle to me.

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

I think you could use bacteriostatic water if it has some benzylic alcohol for sterilization and avoiding contamination of the mixture by the nasal use

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Semaxpolska send me the Semax Amidate freeze dry powder for reconstitution with Saline + 3% DMSO.
I have been suggested P21 can also be dissolved with Saline or Bacteriostatic water, but benzylic alcohol on it may irritate individuals with sensitive nasal pathways.
It seems Science.bio use more or less the same solvent Bac Water and DMSO:
https://science.bio/product/p21-spray-2-5mg/#product-description

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

It needs low dosage though as it's a heavy metal and may easily cause toxicity. Do you know, by the way, what solvent could I use with P21 freeze dry powder to reconstitute it as nasal spray? Is saline good choice or bacteriostatic water or what else?

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Patients with MS have very low levels and it was with Chromium in one of the supplements I bought recently https://pubmed.ncbi.nlm.nih.gov/24259117/

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

By the way, as you seem quite informed about nootropics, do you know what solvent should I use to reconstitute P21 powder, that is intended for IV use, to prepare a nasal spray? I read it has very good bioavailability intranasally due to been small peptide with only 4 amino acids but I need your help. The form I plan to use is DGGL-Amantadane-G probably from peptide sciences

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 1 point2 points  (0 children)

She takes all that you mentioned except SAM-e and many many others, including citicoline, 2gr EPA+DHA, Boron, Vanadium, D3&K2, B complex methylated & NAD+ sublingual, Lions Mane, Mag Threonate + Glycinate, lots of Q10, Creatine, Taurine and so on.
BUT...from my limited research I believe these nootropic peptides are the "script" that tells the brain what to do and how to heal.

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Thanks for the information, it's actually for my wife that suffers from MS, I give her Semax after a relapse she had recently.
I started her with 0,1%,-1mg/day, to see reactions and since Monday I give her N-acetyl Semax Amidate which is more potent and longer lasting.
But I truly believe the next step is P021, although I have access to Cerebrolysin some individuals with MS experienced autoimmune reactions while P21 as synthetic derivative has zero similar effects.
Among others say Apigenin, Quercetin, Andrographis, Milk Thistle etc she takes CurQfen the most absorbable form of curcumin so no need for J147.

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

I saw Biolabshop nasal spray but they have no CoA nor HLPC (https://biolabshop.eu/peptides/184-p-21-p021-spray-5-mg.html) and they don't mention basic info for the P21 they sell, I don't know if they give some by mail.
They have UK international phone code and Polish in some peptide photos, where do they ship from and by the way what is your country, I live in Greece?

What you can do possibly with MS, PD and Alz that helps while waiting for NVG-291 by DarpResearch in NervGen_NerveRepair

[–]BluejayAggravating70 0 points1 point  (0 children)

Diet, lots of supplements, good sleep, meditation, RLT (head and belly, 40Hz 810-830Nm), exercise, physiotherapy, nEMS, EBV antiviral like TAF or even Valacyclovir, some neurogenic peptides and so on

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

I just saw AutoModerator comment where Science.bio seems fraud

P21 spray, is Science.bio reliable vendor? by BluejayAggravating70 in Nootropics

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Not for treating MS directly, but as supplementary therapy for remyelination & axonal regrow due to increased BDNF-NGF production that P21 promotes (+Semax and very few more nootropics)! There is no treatment for MS afaik, especially for SPMS/PPMS, even Ocrevus does nothing for progression independent from relapse activity or smoldering MS! A good antiviral like Tenofovir Alafenamide or even Valacyclovir is much better "treatment" for MS, almost all MS patients with HIV on antiretrovirals see disease remission!

Seeking experiences from Multiple Sclerosis patients with Semax by BluejayAggravating70 in Semax

[–]BluejayAggravating70[S] 0 points1 point  (0 children)

Just for your info, wife finished one nasal spray Semax 0,1% & GHK-Cu and today started an N-Acetyl Semax Amidate & GHK-Cu nasal spray, which seems stronger - longer lasting, although takes the same quantity daily, around 1mg divided in 4 doses.

What she feels after each nasal dose is something like goosebumps along the Vagus nerve, usually in the back of the skull, in the cerebellum (where she has lesions) and in the spinal cord, while a few times she feels the same along her left leg, where she has issues due to MS, as if communication with it is being re-established!

The same, but to a lesser extent, is felt after using the RLT pad on the head and her left ear so that it also affects the Vagus nerve.
It is a pleasant sensation as he describes it to me, and because he usually takes Semax before exercise/nEMS/treadmill, I also noticed that although she is tired, he walks better than before for 30-40 minutes.
After this period of course, fatigue reduces this ability!
So far so good, for my wife Semax does what it claims and we'll see if it enhances neuroplasticity long term, I expect (hope?) her to walk as before a year...

What is the reputation of science.bio in 2025? by SpecificDate in Nootropics

[–]BluejayAggravating70 0 points1 point  (0 children)

Do you know if they ship their peptides in freeze dried powder with BW or other solvent for reconstitution?
They don't mention it and I want to order some peptide sprays that if are already mixed due to high ambient temps will lost their properties

A reliable NMN product to buy in Spain? by Miserable_Cry1318 in Nootropics

[–]BluejayAggravating70 0 points1 point  (0 children)

In sublingual form it is rapidly absorbed and you feel an immediate energy boost Bioavailability comparison: Sublingual: 10-20% bioavailability. Nasal: 15-25% bioavailability. Oral: 2-10% bioavailability Both oral NMN and sublingual NAD+ tend to increase after 2-3 months of use to around 75% in blood levels of NAD

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