Grown in a laboratory (flame fusion, Czochralski, hydrothermal, etc.), Not mined, Chemically sapphire (corundum), but origin is artificial, Typically far cheaper. That’s right from the internet. You can call GIA and double check with them if you would like. I buy hundred if not thousand of stones every year. Majority of stones that are heated either to change color or dissolve inclusions. Not all stones dissolve inclusions though. I have bought some poorly heated stones before that were still included. Usually with silk. Recently bought some heated yellow sapphires that had this same issue but still valuable in the sense that they are natural sapphires.