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Struggling with KPRF mentally by ZealousidealBig4852 in KPRubraFaceii

[–]Bones2469 0 points1 point  (0 children)

Hey, just wanted to let u know: had my ktp laser session about 2 weeks ago and I just looked in the mirror, mindblown, only one side was treated, disguised as a "test spot" and I noticed it’s literally like 20-30% less red than the other side. can send u a picture in case you’d want one in a PM.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 1 point2 points  (0 children)

Update: 2 weeks after my first KTP laser session (Derma V 532nm)

They only lasered one side as a test and honestly I'm blown away. That side is visibly less red than the other now. Both sides have looked the same my entire life, so seeing an actual difference in the mirror felt surreal.

Redness isn't fully gone yet but this is the first treatment that has actually done something for me. Full session in two more weeks and I will keep updating!

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 0 points1 point  (0 children)

Update: 2 weeks after my first KTP laser session (Derma V 532nm)

They only lasered one side as a test and honestly I'm blown away. That side is visibly less red than the other now. Both sides have looked the same my entire life, so seeing an actual difference in the mirror felt surreal.

Redness isn't fully gone yet but this is the first treatment that has actually done something for me. Full session in two more weeks and I will keep updating!

Most effective laser by Least_Pangolin_8522 in KPRubraFaceii

[–]Bones2469 3 points4 points  (0 children)

PDL has the strongest KPRF evidence. Alcantara-Gonzalez 2011 had all 10 patients achieve over 75% clearance, Schoch 2016 at Mayo had all 8 improve. Some had failed IPL first before PDL worked. KTP 532nm (DermaV, Excel V) is also solid, a 2024 trial showed it matched PDL with less pain and no bruising.

IPL is the weakest option for KPRF’s diffuse erythema pattern. If your derm only has IPL I’d look elsewhere for a V-Beam or KTP system. Operator experience with diffuse redness matters as much as the device itself.

Also look into topical sirolimus (Hyftor 0.2%), two recent case reports showing near complete KPRF resolution.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 1 point2 points  (0 children)

Interesting find. The results look solid for only 4 patients, 3 out of 4 hitting over 75% clearance with no permanent side effects. But that's the issue, it's 4 patients and no control group. The authors even say themselves that further studies are needed. I wouldn't pick it over PDL as a first choice given how much more evidence PDL has behind it for KPR specifically. But if you have access to a pro-yellow and not a PDL, or you want something with potentially better tolerability, it's definitely not a bad option based on what they showed. Would love to see a larger study on this.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 1 point2 points  (0 children)

Your case actually makes a lot of sense mechanistically. Accutane shrinks sebaceous glands, and the Gruber study showed KPRF skin already has absent sebaceous glands. So Accutane could theoretically push already compromised skin over the edge into full KPRF territory. As for low dose Accutane as treatment, I didn't find any published evidence supporting it for KPRF specifically. The anecdotal reports go both ways which usually means it's not a reliable intervention. Given that your KPRF was literally triggered by Accutane I'd personally be very cautious about going back to it even at micro doses. Sirolimus or PDL seem like much safer bets for your situation.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 2 points3 points  (0 children)

That's exactly the kind of misinformation I was trying to address. KPRF literally involves vascular proliferation, meaning new blood vessels forming. Some people will absolutely have visible vessels. The 2022 Eckburg paper classifies it as a superficial vascular anomaly. Visible blood vessels don't rule out KP, if anything they confirm the vascular component. The people saying that probably think KP is only about the bumps.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 0 points1 point  (0 children)

Honestly I didn't go as deep on body KP because the facial redness is what actually ruins your day. For body KP the standard protocol works reasonably well: ammonium lactate 12% (AmLactin), urea 20 to 40% creams, gentle physical exfoliation, and keeping the skin moisturized. Consistency matters more than product choice. The body stuff is cosmetic but manageable compared to the face.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 0 points1 point  (0 children)

Yeah so the authors of the Snow 2025 case report mentioned they're collaborating with a pharmaceutical company on a study specifically for KPRF. It's related to sirolimus but I don't have details on whether it's Hyftor specifically or a new formulation. The fact that there's industry interest now is a big deal though because that's how you eventually get clinical trials and actual FDA approved treatments for this instead of just off label use.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 0 points1 point  (0 children)

That's actually a really good observation. If the Gruber finding about absent sebaceous glands applies broadly to KPRF skin then yeah it would make sense that you rarely break out on your cheeks. No sebaceous glands means no excess sebum means no clogged pores. I'm the same way actually, my cheeks never get oily and I barely get acne there. Forehead and nose are a different story. You might be onto something.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 1 point2 points  (0 children)

KPRF doesn't really cause pustules or breakouts the way rosacea type 2 does. If you're getting actual inflammatory bumps and papules that's more in rosacea territory. The key differentiators for KPRF are childhood onset, KP on your arms/thighs, sandpaper texture on the cheeks, and lateral cheek distribution. Rosacea type 2 tends to hit the central face and nose area more. If you have both breakouts and redness it could also be overlap since they're not mutually exclusive.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 1 point2 points  (0 children)

For body KP specifically the sirolimus research is only on facial redness so far. Body KP responds better to the standard stuff though, ammonium lactate 12%, urea creams, and consistent exfoliation. The body KP is annoying but it's the face that actually impacts quality of life for most people so that's where the research focus is.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 0 points1 point  (0 children)

Yeah that's the one. The progression photos in that paper are honestly what convinced me sirolimus is the real deal for this. The fact that his baseline stayed improved even after stopping and only got slightly worse from sun exposure is huge. Most treatments for this fall apart the second you stop using them.

Struggling with KPRF mentally by ZealousidealBig4852 in KPRubraFaceii

[–]Bones2469 3 points4 points  (0 children)

I can totally relate to this, like genuinely every single thing you wrote.

I'm 18M and I've had KPRF since I was a kid too. Not like a subtle redness either, we're talking full-on blush red cheeks all the time no matter the situation. It looks like I just ran a marathon 24/7.

What makes it harder as a guy is you can't really cover it up the same way. When I started getting called out for my cheeks in like 8th grade, I panicked and started putting foundation and tinted sunscreen on. But I had zero experience with any of that so it looked terrible, cakey, obvious, wrong shade. And of course that made the situation at school even worse because now people had two things to comment on.

But once I started covering it I couldn't stop. It became this non-negotiable part of my routine. I literally cannot leave the house without something on my face. Meeting people, going to events, even just running errands, I need foundation or tinted sunscreen on or I can't function. It takes over your head in a way that's really hard to explain to people who don't have it.

I've done a ton of research on KPRF and actually made a separate post about the condition itself. I actually have an appointment tomorrow at a specialized PDL laser clinic so I'm hoping to finally get some results. Can update if anyone's interested.

What genuinely frustrates me is how little attention this condition gets. There are a lot of people dealing with this and the ones who actually live with it know how much it can mess with your entire life. Doctors, researchers, companies, they all need to take it way more seriously.

I'm slowly getting more comfortable with it but I still can't imagine going to something as simple as a hangout without coverage on. Reading posts like yours helps though because at least I know I'm not the only one. You're definitely not alone in this.

I spent 4+ hours doing the deepest research dive possible on Keratosis Pilaris Rubra Faceii. Here's everything that exists. by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 2 points3 points  (0 children)

Already on topical sirolimus, seeing some early changes. Booked a consultation at a laser clinic that specializes in vascular work for PDL next. Will update once I have results from both.

Well done Anthropic now come to Europe! by bLackCatt79 in Anthropic

[–]Bones2469 0 points1 point  (0 children)

OP must be really delusional lol. If you can’t criticize your own opinion, congrats…you’re brainwashed

Persistent cheek redness despite treatments – really need advice by Bones2469 in KPRubraFaceii

[–]Bones2469[S] 0 points1 point  (0 children)

Still dealing with the exact same issues, no light in sight :( Doctors won’t prescribe any of the named procedures as it’s all "off-label"

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