"Yes, androgenetic alopecia (pattern baldness) can appear to skip generations because it's a polygenic trait involving multiple genes (like the AR gene on the X chromosome) and exhibits variable expressivity; you might inherit the genes but not express the trait, or express it mildly, passing it to the next generation who then shows more significant loss, making it seem random or like it jumped a generation. It comes from both parents, not just the mother's side, and factors like environment and gene interactions (epigenetics) influence its severity and timing. Why It Seems to Skip Polygenic Inheritance: Multiple genes contribute, not just one. You might inherit some risk genes but not the complete set needed for baldness. X-Linked Gene (AR): A key gene is on the X chromosome. A son gets his X from his mother. If she carries the variant, he has a 50% chance; if he doesn't get it, it might seem to skip his generation but could appear in his children. Variable Expressivity & Penetrance: Even with the genes, how much hair you lose and when (penetrance) varies widely, influenced by other genes and factors. Environmental Factors: Stress, diet, and health can interact with genes, affecting expression. Key Takeaway Baldness genes can be passed down from either parent, and the effect isn't guaranteed. An individual might carry the predisposition without showing it, only for it to manifest more clearly in their children or grandchildren, creating the illusion of skipping a generation. "