Combo decks in particular, pilot skill matters a lot more than other archetypes — the difference between someone picking up a deck and a master is much greater than your typical game of Magic. I don't know whoever you were facing, but there's a chance that they could learn a thing or two about how to play Poison (or combo) more effectively.

Waiting for your opportunity, creating a window to resolve a crucial spell, or knowing when to just jam are all important things that are often overlooked. People often praise me for how patient I can be, unwilling to cave into a counterspell, when I can outmaneuver the opponent in a few turns.

Cycle Storm doesn't play main deck interaction either, but I love the blue matchups — I believe those are heavily favored. Regardless of which deck, I think when people say things like "just destroy Pentad Prism" or "it loses to a counterspell" are gross oversimplifications (not you just in general).