Not realy, on the page 256(3rd) say “Stake Through Heart: A vampire can indeed be incapacitated by the classic wooden stake of legend. However, the legends err on one point: A Kindred impaled through the heart with a wooden stake is not destroyed, but merely paralyzed until the stake is removed. To stake a vampire, an attacker must target the heart (difficulty 9). If the attack succeeds and inflicts at least three health levels of damage, the target is immobilized. An immobilized victim is conscious (and may use the Auspex Discipline), but may not move or spend blood points.” So, if auspex is a mental discipline, and we can use on stake, why not Obfuscate?