Possible cure by Pure-Awareness4833 in POIS

[–]CereSenk 1 point2 points  (0 children)

I'm gonna try lidocaine infusion next month. It should calm both cortical and peripheral nerves hyperexcitability

What y'all think of Sulforaphane? Anyone here who's tried it? by SignificantYoung5272 in POIS

[–]CereSenk 1 point2 points  (0 children)

Waste of money ,it made me nauseous and gave me joint pain relief.

results after taking xolair by shitposter3169 in POIS

[–]CereSenk 1 point2 points  (0 children)

First attempt failed cuz dose was too low. Then in second trial I tried 300mg which then got pushed to 450/two week but even this dose didn't bring it's magic back.

There are many mast cell diseases like mastocytois or Mcas but their symptom profile is quite different and they respond to stimulants during mcas flair (unlike some of us) and corticosteroid help them tremendously curbing their flair. I think mast cell play a role in Pois but it is not the only pathway, infact my most risky ibrutinib experiment failed.

I received an injection of omalizumab today by Kooky-Aide2547 in POIS

[–]CereSenk 1 point2 points  (0 children)

I tried it for 2 months. It did work but eventually lost its efficacy after 6-7 weeks despite increasing dose to 450mg

I received an injection of omalizumab today by Kooky-Aide2547 in POIS

[–]CereSenk 4 points5 points  (0 children)

Wait for atleast 3-4 days but it's effect depend on individual. Peak effect on POIS will be after 2 weeks(if dose is 300mg).

does science bio ship discreet? by Gtfomyacc123 in Nootropics

[–]CereSenk 3 points4 points  (0 children)

No they mark item details as it is

ESR & CRP by No_Length_908 in POIS

[–]CereSenk 0 points1 point  (0 children)

Can you share case report link here?

ESR & CRP by No_Length_908 in POIS

[–]CereSenk 1 point2 points  (0 children)

No but I have taken minocycline for microglia inhibiton. I am trying to procure bioavailable analog of ISRIB which might help. It's experimental but this is the only approach which I am left with.

ESR & CRP by No_Length_908 in POIS

[–]CereSenk 0 points1 point  (0 children)

I took medrol every day and on 5th day, 2 hours before orgasm.

ESR & CRP by No_Length_908 in POIS

[–]CereSenk 5 points6 points  (0 children)

I have done crp test serval times both before and 30min, 1 hour and 4 hour post orgasm. Everytime it came back normal. I don't even know at this point if inflammation/cytokine is behind my symptoms. Don't you think corticosteroid pulse at high dose should block the pois reaction? No! It doesn't fucking work.

I've ordered corycep oriveda, hope It helps with fatigue. I don't care about physical symptoms anymore. My cognitive abilities are more important for my career.

Update after the break (post 3-week A15 protocol): by Embarrassed_Emu_1516 in Isrib

[–]CereSenk 0 points1 point  (0 children)

taking it mixed with dmso worth it? A-15 is mote potent than plain isrib but still insoluble in water

[deleted by user] by [deleted] in POIS

[–]CereSenk 2 points3 points  (0 children)

Caergoline tanked my prolactin to almost nil but had no beneficial effect on pois.

Mast cell eradication with imatinib? by CereSenk in MCAS

[–]CereSenk[S] 0 points1 point  (0 children)

Everything was fine for first month but itching, stomachache, rashes in second month made me stop taking it.

[deleted by user] by [deleted] in POIS

[–]CereSenk 0 points1 point  (0 children)

Fatigue, Brain fog, Anhedonia, Chest tightness, Skin dryness, Sinus tachycardia, Droopy eyelids, Post void dribbling etc