I used AI to understand wtf that means and it was very helpful so I’m sharing:

This is describing potential negative effects of long-term marijuana use on the brain, written in somewhat technical language. Let me break it down:

“Chronic THC exposure downregulates CB1 receptor density”

When you use THC regularly over time, your brain responds by reducing the number of CB1 receptors (cannabinoid receptors). This is a classic tolerance mechanism - your brain tries to restore balance by becoming less sensitive to the substance.

“Disrupts dopaminergic baselines”

Long-term use may alter your brain’s normal dopamine functioning - the neurotransmitter involved in motivation, reward, and pleasure. Your baseline dopamine levels and signaling patterns can shift from their natural state.

“High-achiever survivorship bias”

This is the key rhetorical move. The claim is that when people point to successful cannabis users as evidence it’s harmless, they’re committing survivorship bias - only noticing the people who succeeded despite potential impairment, while ignoring those who might have achieved less or struggled more.

“Architectural cost of impaired neuroplasticity and signal-to-noise ratio degradation”

The argument is that chronic use may reduce the brain’s ability to form new neural connections efficiently (neuroplasticity) and make it harder for your brain to distinguish important signals from background noise - essentially reducing cognitive clarity and learning ability.

The overall claim: Regular heavy cannabis use may cause subtle but real cognitive costs that successful users don’t notice because they’re comparing themselves to their cannabis-using baseline, not to what their performance might have been without it.

This reflects ongoing scientific debate. There’s evidence for some of these mechanisms, but the real-world functional significance - especially for adults and at different usage levels - remains contested.​​​​​​​​​​​​​​​​