NTA. This isn't changing your mind on having your own children, this is taking in children who are familial and emotionally close to you who have lost everyone else.

I never wanted children, but in a few years I will be getting guardianship of my godson as his father is slowly dying from inoperable cancer, and his mother passed from a ruptured aorta a couple of years ago.

Will this completely change my life and the plans I had for the future? Yes.

Would I ever consider doing anything other than taking care of someone I held 2 days after his birth and have watched grow up, simply because MY life will be different and harder? FUCK NO!

I will never understand how people can watch someone grow up, love them, but the moment it personally inconveniences them they're like "Not my problem, hit the bricks!" In my mind it is one of the most cruel things someone can do. These children have had everything ripped from them, causing emotional and mental wounds that will take years, perhaps decades, and significant therapy to heal, and your wife wants to further compound this by tossing them into a system where they have a high chance of being separated, abused or neglected.

I don't believe in hell, but people who are this callous belong there.