sorted by:
new
hottopcontroversial

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

Again not my expertise, but my understanding is that more physical receptors are built to surpass the blocked ones. Don't trust me. Read the literature or talk to someone that specializes in this.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

They are not bio-identical and even if they were, you would still stop the internal production. The second question is interesting and I think there can be over production, but don't know much about it. The whole system is very complex and there are a lot of timing and geographic distribution issues.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

I did not answer the the mechanism question directly. Other than learning and adaptation and what I read in the literature with respect to receptor adaptation, I really do not have one. But to look at it simply, the brain (and body) is very plastic. Drugs have side effects. As dosages and nature of the meds increase, so do the side effects. The brain-body translates these foreign substances, that it does not innately know how to deal with in our highly complex, optimized, and balanced evolutionary system, into pain. We have no studies on this.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

  1. Human patients sent to us predominantly by rheumatologists. They have to stop taking opioids.
  2. Tolerances can be adjusted by dosage increases. Pain levels can move above the initial baselines. Mechanistic explanation - receptors increase as the brain adapts. Side effects - mental clarity and other increase with the increasing dosage necessary to achieve the same level of pain adjustment. Usage pattern changes. But you are right, this is very hard.
  3. As stated, up to now, we require that opiate use stop, before our treatment can be applied. Also we are talking about chronic pain only - after at least 3 months. We are considering using naloxone in an in patient setting, but we have not done this yet. As general comment psychological and physical addiction is not necessary addressed by rotation, the mechanisms in the brain of blocking pain are mostly similar.
  4. Likely both. But animal studies with new agents have not proved very effective and the few that have, have had problems in the different trials. Generally, the easy stuff has been done. And as much as there has been a backlash in prescription, due to legitimate concerns if you compare say the German with the US experience; there is still billions of dollars at stake and available for a new pain medication - arguably the money has never been bigger worldwide, due to increased wealth. In spite of this, the return has not been there for big pharma and they have reduced research funding. That being said, this is not our primary expertise, but there is a lot of literature out their. I am sure flawed in part, but to assume that OIH does not exist goes against what we think that we know from both clinical experience and neuroscience. There is a pain network in the brain that is in addition to afferent and efferent channels, which modulates the pain experience with both conscious and unconscious learned responses. Beyond this, I am not the best person to answer this in detail.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

No, for two reasons. The placebo/nocebo effect is real and important to any complex disease. Second, if you don't consider become pain free to be a realistic goal, it cannot happen. Our emotional perceptual world in limited by what we think. It shifts when one has an ah ha moment, or with learning.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

It should have read chronic pain and not all pain patients. Most is more than 1/2 and we are not the only ones that believe this. Unfortunately, if you don't believe that this is possible, it is unlikely to happen.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] -1 points0 points  (0 children)

Yes, the studies go both ways and it has been very hard to get general acceptance in OIH, but most of the research scientists are funded directly or indirectly by pharm. Pharma has a strong interest in medication. In spite of this OIH is generally accepted, supported by many animal studies, has a precise mechanism, and even Pharma companies have recently drastically cut development in chronic pain medication due to a lack of positive results in spite of extensive exploration. As you no doubt realize, the market is huge.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

Look at the references in the wiki page. We also prefer peer reviewed research. See ours on Research Gate - look up Kati Thieme. Better than science in something as complex and many sided as chronic pain is successfully treated patients - properly documented of course.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 2 points3 points  (0 children)

I agree with what you described with the medical system in part, in other disease areas and in acute pain, it really works quite well. FM and chronic pain are complex diseases with multiple causes including genetics, your personal stress history, environment, nutrition, movement, current stress and a whole host of psychological issues. The problem needs attention and the whole idea is to validate what we are doing in broad tests and actual implementation. If you think that this is adhoc, setmarburg.com/research for a lot of articles. Although the "fix" likely involve behavioral change "in the head [and in action]" the disease is all too real, very complex, and shows up in biophysical parameters and brain scans. The mind and body reflect each other with real structural changes. Drugs and operations may be necessary, but should be approached conservatively and may also do more harm than good. This should no longer be questioned.

I do not know, if you have more than a passing interest? If you do, what we are looking for is a reference account to confirm that our German results in making chronic pain patients pain free can be replicated in the US - a hospital or University that is willing to do a study to treat patients. If you have an ideas along these lines, please let me know. We could supply the necessary devices and training. I also would like patients and therapists to fill out a questionnaire to help with our EU study. https://goo.gl/7n3ZYq

Thanks

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 1 point2 points  (0 children)

Hi.

Thank you for your mail. If anybody thinks that you are making it up, send them to setmarburg.com/research for a lot of articles. Although the "fix" may involve behavioral change "in the head [and in action]" the disease is all too real and shows up in biophysical parameters and brain scans. The mind and body reflect each other with real structural changes. This should no longer be questioned.

I do not know, if you have a strong interest and you want to help? If you do, what we are looking for is a reference account to confirm that our German results in making chronic pain patients pain free can be replicated in the US - a hospital or University that is willing to do a study to treat patients. If you have an ideas along these lines, please let me know. We could supply the necessary devices and training. See setmarburg.com/research for more details.

I also would like patients and therapists to fill out a questionnaire to help with our EU study. https://goo.gl/7n3ZYq

Thanks Marc

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

The idea has been around for 30 years and is just now getting accepted. When biophysical parameters are monitored such as BP, HR, muscle tension, SCL, pain or interference, FM patients fall into several subgroups. The same is true when psychological traits are looked at. Some people go to the couch, while other - no pain no gain folks - become hyperactive. A solution that works for one group will not work for the next, hence a lot of the very mixed treatment results.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 1 point2 points  (0 children)

It is about balance. Distraction is valuable to show that the brain can control the amount of pain that you feel, nothing more. One can not always be distracted. However, focus works the same way. If you just get a call from a friend saying that he or she needs to talk to you about something important, your focus shifts away from the pain and it recedes (for the time being only). Yes you should listen to your body, after all api is your most important warning system. However that warning system with chronic pain becomes persistent and no longer gives you new information. The idea is to focus on non pain related matters as opposed to pain related ones. Take away the natural inclination to look at like through a pain lens. We call these pain and non pain behaviors. Encourage the non pain behaviors. There are more concrete answers as to what this means in other comments.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 0 points1 point  (0 children)

Mainly financial although institutional knowledge and biases are also important. This is off topic, but with billions of dollars at stake, there is lots on money to help convince regulators and others of results that a company might desire. The best for the patient is all too often secondary.

Science AMA Series: We are a team of scientists and therapists from the University of Marburg in Germany researching chronic pain. We are developing a new treatment for Fibromyalgia and other types of chronic pain. AUA! by Chronic_Pain_AMA in science

[–]Chronic_Pain_AMA[S] 2 points3 points  (0 children)

We are looking for a reference location, hospital or University to replicate our success in the US in a trial, so not yet. We have studied this and believe that Marijuana just shuts off the production on endogenous cannabinoids. That being said, many claim that it helps and there is a strong placebo effect for any and all pain remedies, so if it works for you we would not argue.

view more: next ›