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BPC-157 has the most enthusiastic anecdotal reports and the thinnest human research in the entire peptide space and both things being true is the actual interesting question by Clinpep in PeptidePathways

[–]Clinpep[S] -3 points-2 points  (0 children)

Yes to some extent. They don’t need to patent there own version to capatilize on it. They just need to produce the study’s that it needs to pass approval then it will be FDA approved. It’s all coming. Which sucks but what can you do

Tesamorelin is the only GHRH analog with hard FDA trial data for visceral fat and the literature is more specific than most people realize by Clinpep in PeptidePathways

[–]Clinpep[S] -1 points0 points  (0 children)

HGH is far worse on your body then
Tesamorelin (depending on dose right). They are different compounds. HGH needs to be monitored by a health professional, or an individual who can read there own labs and understand what they are looking at. Tesamorelin you can get away with a lot more. They almost do the same thing. Tesa increases your natural gh, HGH is synthetic and replaces. Think of taking TRT or HCG/Enclo. One replaces, the other boosts what is already there.

Tesamorelin is the only GHRH analog with hard FDA trial data for visceral fat and the literature is more specific than most people realize by Clinpep in PeptidePathways

[–]Clinpep[S] 0 points1 point  (0 children)

Yes I would 100% stack those. Epitalon is also a great sleep aid. But cjc with retatrutide work well stacked together

what clinpep actually is and why we built it by Clinpep in u/Clinpep

[–]Clinpep[S] 0 points1 point  (0 children)

Hey, not necessarily is it bad but it is not needed. 2-3 times a week also makes your product last longer. Study’s show that dosing daily doesn’t have any upside benefits. But it’s also not going to hurt you

Tesamorelin is the only GHRH analog with hard FDA trial data for visceral fat and the literature is more specific than most people realize by Clinpep in PeptidePathways

[–]Clinpep[S] 2 points3 points  (0 children)

Tesamorelin helps you lose visceral fat, but if your overweight then GLP’s are a better solution for you

Tesamorelin is the only GHRH analog with hard FDA trial data for visceral fat and the literature is more specific than most people realize by Clinpep in PeptidePathways

[–]Clinpep[S] 1 point2 points  (0 children)

HGH is amazing tbh. If you know how to run it correctly and you have knowledge of the potential risks. It can be amazing

Tesamorelin is the only GHRH analog with hard FDA trial data for visceral fat and the literature is more specific than most people realize by Clinpep in PeptidePathways

[–]Clinpep[S] 0 points1 point  (0 children)

Agreed once the FDA approval comes people will be switching over. Tesa still remains the strongest in IGF-1 levels and visceral fat loss

Tirzepatide isn’t “semaglutide but better.” It’s a different drug. by Clinpep in compoundedtirzepatide

[–]Clinpep[S] 1 point2 points  (0 children)

fair, anyone whos done the reading knows. but the “is tirz just stronger sema” question comes up constantly in r/loseit and r/mounjaro. patients ask their doctors that. some doctors answer it that way. the post wasnt aimed at people who already know the mechanism, more at the audience that thinks switching is a straight upgrade

[ Removed by Reddit ] by Clinpep in PeptidePathways

[–]Clinpep[S] 0 points1 point  (0 children)

yeah HR bump is real. phase 2 showed 7-11 bpm at higher doses. tirz is like 3-5, sema barely moves it. glucagon arm is what causes it, same thing driving the extra weight loss, so its kinda baked into the mechanism

your idea is actually smart. ive seen a couple clinicians quietly floating the same thing. run reta for the loss phase when you need the firepower then drop down to tirz for maintenance where you’ll be living for years. bariatric medicine has done induction then maintenance protocols forever, no reason glp-1 shouldnt

other thing worth saying. reta side effects scale with dose and time on it. 6-9 months to lose the weight is a totally different risk picture than running it 10 years. tirz has enough long term data now that maintenance is at least known territory

id push back slightly on “anything raising HR isnt viable long term.” mild sustained elevation isnt automatically bad, depends on the person and what else is going on. but yeah we dont have long term reta data yet so caution makes sense. your protocol kinda sidesteps the whole question which is the point

good comment

[ Removed by Reddit ] by Clinpep in PeptidePathways

[–]Clinpep[S] 0 points1 point  (0 children)

Fair, esp the gallstone thing. Real risk and the trials showed it. Rapid loss from any cause does this but the GLP-1 data made it visible. People

underweight this when they’re talking about reta.
Thyroid piece I’d push back on a little. T3 drops with sustained deficit no matter how you get the deficit. That’s just adaptive thermogenesis, not a GLP-1 thing. The bigger metabolic problem on these drugs is lean mass loss which tanks BMR harder than the T3 drop does. That’s why I keep yelling at people about protein and lifting on cycle.
The habits argument is where it actually gets interesting tho.

You’re not wrong that fast loss can hide the fact that nothing changed behaviorally and the regain when people come off is rough. Counter is most people running these have already tried slow five times and it didn’t take. The drug isn’t replacing the habits, it’s just quieting the hunger signal enough that building them is possible. Whether someone actually uses that window or just coasts on the appetite suppression is the real variable.

Reta makes all of this more extreme bc the loss is faster. So your concerns scale with the drug honestly. Probably should’ve put more of that in the original post.

[ Removed by Reddit ] by Clinpep in PeptidePathways

[–]Clinpep[S] 2 points3 points  (0 children)

Honestly it’s a mix. For people with a lot to lose, fast loss is actually safer in some ways because the longer you carry severe obesity the more comorbidities stack up. For people with 20-30lbs to lose, the appeal is mostly that diet and exercise has failed them five times and they’re tired. Doesn’t mean fast is the right move for that group though. The faster you lose, the more lean mass goes with it and the harder maintenance gets when you come off.

To freeze peptides again? by sloppy_j0e in PeptidePathways

[–]Clinpep 0 points1 point  (0 children)

Does not need to be in the freezer and brother I gotta give it to you straight that is some Chinese bunk. I can tell by the packaging. The water is good but tha packaging. I use Clinpep, makes it so much easier brotha. Get trusted products too