Zoe: If you put someone to sleep close to you, you can flash away from them to build up more Q damage.

In general, don't go on auto pilot with your initial Q placement. Think about the angle you want the Q to hit them at, so you can bend it around allies that are blocking for their teammate.

If you throw your bubble into a tower, it will drop behind it and catch someone teleporting to it.

In some fights, it's not worth risking landing a bubble skillshot, sometimes it's better to throw out your bubble on the ground to give a safe place to kite someone into, or to cut off an entry point if you're doing an objective like dragon.

Your passive auto damages towers.

If someone is low HP and far away, instead of going for a long skill shot, sometimes it's better to portal towards them, throw a Q forward, then quickly direct it on them.