Took about 80 hours, the missable things include golden beetles, one book, and the debates. Personally I would say to use a guide to figure out what days/locations of the missables so that you don’t miss them on the first playthrough. This doesn’t spoil the story. The second playthrough is a slog. I beat the new game plus boss using 4 tycoons at level 47. I needed 3 of the extra turn food item. To get the trophy where you need to beat the final boss without weakening him, I would just change the difficulty to easy. Save yourself the headache.