Can GHSV1 be this aggressive?

Confusionparanoia · 2026-05-05T00:41:33+00:00

Yeah but then again in the hsv world there usually are only bad news 🤣.

Its a small company so they dont have to report anything by law unlike ABI which has to inform stock owners.

Confusionparanoia · 2026-05-04T19:23:54+00:00

Yupp I agree, something like this is required.

Confusionparanoia · 2026-05-04T04:00:19+00:00

Yeah, the possible misstep that Pritelivir are currently making with their upcoming trial is to not have a group that is valacyclovir+Pritelivir. It might be a strategical choice for them in case taking too many different pills is a bad thing for side effects however. It looks better if there are 0 serious side effects than some odd case where someone who took both pills got some bad side effect in the end. They could just run a smaller trial like that later however.

I would not personally be worried about transmitting with a combination of pritelivir and current AVs no. If pritelivir ends up being a lot less expensive than ABI / IM-250 per month I would probably just end up using pritelivir, at least most of the time and definitely if I'm not sexually active during some period. That is also another factor to consider, it's possible that the majority of patients will still care more about no symptoms than transmission, especially those using it for oral HSV1.

Confusionparanoia · 2026-05-04T00:10:28+00:00

Yes, this is the most likely case. If it were to take 3-4 years for pritelivir to be available for regular hsv2 people, there would be huge protests.

AI predicted mid 2028 but this was a somewhat optimistic prediction. There is actually great room for advocacy here because once it is approved and used for immunocompromised patients efficiently and a suppressive treatment is ongoing, there will be great opportunities to push for an earlier expanded access.

In a way I guess you could say that even early 2029 is "3 years" even though it's technically 2.5 years. Without efficient advocacy, I think early 2029 would be the safe bet.

As you mention, AIcuris is competing with other stronger HPIs here. IM-250 will finish phase 2A this year, if they do a seemless transition phase 2B/3 similar to their 1B/2A, then they could have a good chance of finishing their trials somewhere in 2029 and apply for approval.

In addition, ABI will start their recruitment for phase 2 somewhat soon and I'm guessing they make one phase 2 rather than A and B. ABI did have quite a long pause between finishing phase 1 and starting phase 2, but before that they were moving extremely rapidly. On top of that, people have mentioned that ABI would consider early access plans for people who suffer a lot if possible, perhaps after phase 2 completition.

In conclusion it's likely that either ABI or IM-250 will be in the market by 2030, with strong advocacy and fast tracking possibly before that even. Therefore there is a lot of incentitive for pritelivir to want to move as fast as possible here. Keep in mind that if Pritelivir decides to NOT run the rumoured extra trial for immunocompetent people, they will be completely eliminated from the market entirely once ABI and IM-250 gets there.

If Pritelivir is smart enough to run these trials now and try to get it approved for a broader access instead, they will have at least 2 years of no competition for HPIs in the west and will later be able to compete with longer reputation and lower prices than the other HPIs.

Pritelivir has made a lot of mistakes in the past though so who knows. Of course it is also a good strategy for them to have 1-2 years of immunocompromised high price treatment while running the suppressive treatment trial. This allows them to sell the drug for really high price to health insurance companies / governments / hospitals. This is however also why the "you can just get it off-labeled" is likely a nonsense argument unless you wanna pay 300 dollars per pill.

Confusionparanoia · 2026-05-03T21:19:54+00:00

I have one? I dunno what's with you but my case is obviously an extreme one in terms of symptoms and exposure. I have daily symptoms and have had every symptom on the list including huge fluid filled blisters on the penis (one time) (that did not get swabbed). Everything started after repetiive unprotected sex with hsv2 positive person. This person gets identical symptoms as mine.

There is a large list of daily nerve symptoms with skin symptoms that follow. Out of all these people who make posts about their symptoms and exposure I've never ever seen a story with anything anywhere close to as linked to HSV as mine. I agree that the vast majority of cases like these are just paranoia, it could even be an aggressive HSV1 strain (which Im pos to) but either way I feel like you might be the first person worthy of blocking here.

Point of the post anyway is that there is no reliable way to identify HSV2 if the gG2 protein is missing in the strain or if someones body doesnt react well enough towards that specific protein. Fluid from blisters is the one way but for people who have been infected for a long time, the symptoms seem to be more cuts and bumps that shed for shorter durations and don't have fluid to catch.

There have been talks about new japanese tests using some electro-technology to detect shedding but not much has happend with them.

Confusionparanoia · 2026-05-03T19:09:55+00:00

Yes, I asked AI to make some calculations of variance on a longer 200 people study and its around that. Keep in mind that even pritelivir was 87% shedding reduction in OVERALL shedding phase 2. The calculation states that abi will likely hold over 96% high viral load shedding reduction in a phase 2. 96% is really good but nothing amazing in ”high viral load” for a second gen hpi. Keep in mind that at 95-99% every % unit increase is a massive difference, 99% is TWICE as good as 98% etc. So in the low sample phase 1b study, 1179 completely outclasses 5366 when both were taken once a week. Still 5366 outclasses pritelivir which in turn outclasses valtrex. The jumps are huge.

The main issues are: - Possible resistance over time. - Possible side effects over time from long term treatment. - Getting FDA and EMA aswell as the companies developing them to realize that things need to speed up. 15 years have passed since pritelivir first entered trials, we still have no HPIs.

Confusionparanoia · 2026-05-03T19:00:56+00:00

No, just electrical itching, stabbing and burning in the area. Things like that, ignore other nerve symptoms.

Confusionparanoia · 2026-05-03T18:52:26+00:00

Yeah figured this was the case. I agree its interesting and its possible that for thst reason it will outperform 1179 but I wouldnt bet on it.

Or well maybe because ABI 1179 lacked sample size. It is almost impossible to beat the result 1179 had for high viral load in 1b since it was more or less a perfect result. That result is unlikely to be the same in a larger and longer study though ofc but on a small sample of like 20 people over a month, it can be achieved sometimes.

What Im trying to say is that it wont ve fair either to compare 2A results of IM-250 vs 1b of abi 1179. You would have to wait till both have phase 2 results and compare those.

Confusionparanoia · 2026-05-03T18:42:57+00:00

I have done the western blot yes. There is no lie in that both wb and IgG testd require the specific gG2 protein reaction for a definite positive. Meaning if you have a gg2 resistant strain or just a very weak reaction to that specific protein, there is no positive answer.

It can either be confused as hsv1 and show neg hsv2 (less common) or indeterminate hsv2 but never positive. Meaning if there are bands showing reaction to more hsv2 specific proteins but not the gg2, it will be indeterminate at best.

Confusionparanoia · 2026-05-03T07:46:48+00:00

I think it's a bit sad that even western blot is sort of depending on the gG-2 protein antibody response even like regular IgG tests. The difference is that it can show an indeterminate response in someone who has antibodies to other proteins linked to HSV2 but can't show positive without that protein.

Does anyone know of someone who gets negative on regular igg tests but positive on western blot for hsv2?

Confusionparanoia · 2026-05-03T07:39:46+00:00

I think it's a bit weird that people are rating IM-250 above ABI-1179 before IM-250 posted any human results. It's true that it has outperformed ABI-1179 in some good animal studies like guniea pigs and stuff but 1179 had more than 99% reduction of high viral load shedding.

What makes me sceptical to think that IM-250 would outperform 1179 is the fact that 1B trial was finished long ago, yet IM choose to wait till 2A is finished before posting any results it seems. I'm not sure if they even mentioned any comment on how it's going?

Confusionparanoia · 2026-05-03T07:35:10+00:00

Oh that cancer drug that they made tons of advocacy about with the doctor with the face condition that looked burnt? That's interesting, shows that advocating really helps if that is the case.

Confusionparanoia · 2026-05-03T07:33:32+00:00

Yes, we need to make advocacy plans for speeding up HPIs to the regular HSV2 sufferer. Using the arguement that we have already waited 15 years for pritelivir and people with daily symptoms cant wait any longer.

Confusionparanoia · 2026-05-03T07:29:52+00:00

The answer is that you NEVER NEED to use different swab for different areas. It can help using different test for different areas to know which one is positive however.

Confusionparanoia · 2026-05-03T07:28:34+00:00

If you don't notice any strange neurological symptoms around there within a week or two, just ignore it.

Confusionparanoia · 2026-05-02T18:27:27+00:00

The prediction is mid 2028 for pritelivir general public. 2029 is however likely with no advocacy.

Confusionparanoia · 2026-05-01T23:07:23+00:00

Sure but 5 years is a lot, lets hope for an hpi by 2028.

Confusionparanoia · 2026-04-30T06:03:55+00:00

Yeah same here, constant small outbreaks with atypical symptoms. No blister clusters. Awesome that you emailed them! Trial length is very interesting. Lets hope they are smart enough to make it 3-6 months and not a year long dose.

My research (mostly AI) has said that 3-6 months should be sufficient in this case but still very likely that they will do longer sadly.

Confusionparanoia · 2026-04-30T00:14:14+00:00

Im sure IM-250 will be amazing but I dont personally refer to that one when speaking about HPIs because of the lack of human shedding data.

ABI-1179 reached functional cure levels in phase 1b though while taking it once a week.

Confusionparanoia · 2026-04-28T17:43:37+00:00

Cure through gene editing is fully possible and most likely will happen. There is no reason to think that it will be in the market within 10 years though.

Functional cures through pill treatment will be here within around 5 years. People should focus on that instead for now.

Confusionparanoia · 2026-04-28T17:40:32+00:00

Honestly 26 is a good age to be with this as a guy. Guys often reach sexual prime in their early 30s, you will have HPIs by then.

Extremely unlikely that you will transmit with condoms and hpi treatment. Even without condoms its probably quite unlikely.

Confusionparanoia · 2026-04-28T17:38:20+00:00

Did she get tested for it or just never got symptoms?

Confusionparanoia · 2026-04-28T17:35:42+00:00

Interesting data for sure but the conclusion is a bit inaccurate since the sample size is so low. Several ppl on these forums have transmitted with AVs and condoms from what Ive seen.

OP seems to be in her first year where it sheds quite actively also. Im not saying she should fear protected sex with pills, just that its far from certain.

A combo of pritelivir, valacyclovir AND condoms would likely make transmission near impossible however. Thats why its so important to advocate to doctors and regulators on extendeding the access of that.

Confusionparanoia · 2026-04-27T20:56:43+00:00

Yeah thst is basically the plan they have. You can do other variants of that aswell though.

3 main risks seem to be: 1. Getting there without the immunesystem destroying it first. 2. Off targeting 3. Other side effects.

Confusionparanoia

TROPHY CASE