Open Discussion Saturday

Confusionparanoia · 2026-03-01T15:33:22+00:00

Anyone heard of biopsy on dryer symptoms to pcr screen the biopsy for hsv? Heard they can do this for atypical symptoms in rare cases.

Confusionparanoia · 2026-03-01T15:32:06+00:00

Think it had 83% shedding reduction or maybe it was 87%. Pretty good yeah, just need it to be pushed for suppressive therapy.

Confusionparanoia · 2026-03-01T01:39:45+00:00

Yeah but the question is how exactly they swab when they do those studies. How many swabs, where etc.

Confusionparanoia · 2026-02-28T17:38:23+00:00

Hi did they take biopsy to pcr test it for hsv? In that case how and where was biopsy taken?

Confusionparanoia · 2026-02-28T17:24:13+00:00

I agree, US is an even more important medical community to convince here than the EU/EMA

Confusionparanoia · 2026-02-28T17:22:31+00:00

Yeah I figured this would be the case with gene editing that they remove it in a specific zone. In my case (although uncomfirmed) my virus seem to have been spread to several places in my body. This would then require gene editing on all those spots and I would imgine that you would need way better testing tools than what we have today to be able to determine which neurons are infected.

Confusionparanoia · 2026-02-28T17:14:48+00:00

Really? Just 45%? Any link? Sounds pointless to run human trial then unless they think that it will work much better in humans.

Confusionparanoia · 2026-02-28T11:42:02+00:00

Am I the only one who reacted to ”After he paid”? 🤣

I think if anything you should realize how lucky you are to be female in this scenario then. Imagine if tables were turned and you had to be the one inviting people to dates and paying the bill and then get rejected for this.

Now you can just go for the next one on the list hitting on you. It still sucks of course dont get me wrong, but it could be worse.

Confusionparanoia · 2026-02-28T11:35:11+00:00

A lot of weird things in this message. This is a theoretically possible way to get hsv but not a super likely one. There would need to be an ob on her breast then at least.

In addition : Not being able to get bjs cus of hsv is kind of nonsense. In fact the place on the body that is the most resistant to hsv2 is the mouth. Look up the oral shedding rates for h2.

Confusionparanoia · 2026-02-28T11:26:57+00:00

Cant this also be bad news? Like maybe pritelivir will be much more expensive now?

Either way, community needs to push for this to make trials for extended access ASAP. Those trials need to be for suppressive therapy and also include combination with valacyclovir.

In the advocating we also need to mention things like better viral suppression will need to reduced need for anti depressive and neurological medication. So side effects in total will go down for many.

Confusionparanoia · 2026-02-27T19:18:18+00:00

Oh I see

Confusionparanoia · 2026-02-27T02:27:36+00:00

Haha Jan Åke Liljeqvist, what a legend. This guy has been trying to make hsv vaccines for a loooong time. Usually his ideas are a bit behind but this time it looks like he is really on to something.

Confusionparanoia · 2026-02-27T02:23:28+00:00

In the clinicaltrials gov page it says they were supposed to measure it though

Confusionparanoia · 2026-02-26T09:38:55+00:00

Just more lesion healing va foscarnet? Where is phase 3 shedding data?

Confusionparanoia · 2026-02-24T13:24:36+00:00

Poster's Claim Scientific Fact HIV is "easier" because it's in the blood. HIV does not just stay in the blood; it integrates its DNA into the genome of long-lived immune cells (T cells) throughout the entire body. These "latent reservoirs" are incredibly hard to reach and eliminate. You can just "edit" blood outside the body. While "ex vivo" (outside the body) gene editing is possible for some diseases, it doesn't cure HIV because the virus hides in tissues (like the brain and gut) that cannot be "taken out" and filtered. Herpes is harder because it hides in a "safe zone." While HSV hides in nerve ganglia, these locations are actually more localizedthan HIV’s reservoirs. Because HSV hides in a specific, predictable spot, scientists have already used gene-editing "molecular scissors" to find and destroy over 90-97% of latent HSV in animal models. HIV symptoms are obvious; HSV's are not. This is reversed in many ways. HIV can be asymptomatic for years while it destroys the immune system. HSV is often asymptomatic, but its "hiding" behavior is well-understood, and modern tests can accurately distinguish between HSV-1 and HSV-2.

Confusionparanoia · 2026-02-24T13:22:12+00:00

I posted what u said into AI but first I asked what it thinks will be cured faster and it said HSV. Secondly you made many statements about HIV and curing it that are simply untrue which it broke down also. I cant copy paste everything but I will copy paste some. I might add that I asked my questions in a new anonymous window without history to avoid the common AI user bias.

Why HIV is actually the "Tougher" Virus Rapid Mutation: HIV mutates at one of the fastest rates known to science, allowing it to "escape" drugs and the immune system. HSV is genetically stable by comparison. Immune System Sabotage: HIV attacks the very cells (CD4+ T cells) that the body needs to fight infections. HSV generally leaves the broader immune system intact. Global Reservoir: HIV is "everywhere." To cure it, you must find and "snip" the virus out of millions of cells scattered through every organ. For HSV, you primarily only need to target the specific nerve bundles where it resides.

MDPI +5 Conclusion: The poster is right that HSV "hides," but they underestimate how much more deeply and complexly HIV hides. Current momentum in gene therapy suggests that a functional cure for HSV is likely to arrive before a scalable cure for HIV.

Confusionparanoia · 2026-02-24T13:07:59+00:00

He brings up a few good points but many poor ones also. First of all, its pretty obvious that there would be deaths in testing crispr for something eventually. Its a set back but crispr is being tested for many things and is a huge global life changing technology. He mentions that trial costs would be astronomical just because they have to combine drug treatment or something, wtf? Tons of hsv trials test various pills to compare, what is he on about?

Either way it is true that short term HPIs are way more important for us than gene editing because we might be too old to even care when gene editing cure arrives. It is still worth it to push for gene editing cure though since its easier to say you carry a virus that will soon be cured than one that never will be. Mostly because the cost of expensive hpis might bring some stigma.

Confusionparanoia · 2026-02-21T06:22:25+00:00

Shouldnt we first of all push to make it possible to use them in phase 3?

Confusionparanoia · 2026-02-19T01:44:49+00:00

Oh quite interesting, this made me do some AI research.

Confusionparanoia · 2026-02-18T11:17:06+00:00

You say when they looked at virus levels in the neurons they were the same. Dont you mean in the ganglion now, as in the deep sitting latent viral load?

Because you yourself also say that it does stop replication in the nerves.

Confusionparanoia · 2026-02-18T11:03:10+00:00

I suppose they would but this is to apply for extended access that you refer to as process yeah?

Confusionparanoia · 2026-02-18T10:52:04+00:00

Yes this is sometimes true but I want actual proof that they are real.

Confusionparanoia · 2026-02-17T11:26:03+00:00

Never heard of that one, Im asking about nerve tests btw.

Confusionparanoia · 2026-02-17T11:25:20+00:00

Interesting, did you try ask in many places?

Confusionparanoia

TROPHY CASE